Abstract
OBJECTIVES: The purpose of this study was to determine the effect of hospital volume on long-term survival for women with breast cancer. METHODS: Survival analysis and proportional-hazard modeling were used to assess 5-year survival and risk of death, adjusting for clinical and sociodemographic variables. RESULTS: At 5 years, patients from very low-volume hospitals had a 60% greater risk of all-cause mortality than patients from high-volume hospitals. CONCLUSIONS: Hospital volume of breast cancer surgical cases has a strong positive effect on 5-year survival. Research is needed to identify whether processes of care, especially postsurgical adjuvant treatments, contribute to survival differences.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Adami H. O., Malker B., Holmberg L., Persson I., Stone B. The relation between survival and age at diagnosis in breast cancer. N Engl J Med. 1986 Aug 28;315(9):559–563. doi: 10.1056/NEJM198608283150906. [DOI] [PubMed] [Google Scholar]
- Ayanian J. Z., Kohler B. A., Abe T., Epstein A. M. The relation between health insurance coverage and clinical outcomes among women with breast cancer. N Engl J Med. 1993 Jul 29;329(5):326–331. doi: 10.1056/NEJM199307293290507. [DOI] [PubMed] [Google Scholar]
- Diehr P., Yergan J., Chu J., Feigl P., Glaefke G., Moe R., Bergner M., Rodenbaugh J. Treatment modality and quality differences for black and white breast-cancer patients treated in community hospitals. Med Care. 1989 Oct;27(10):942–958. doi: 10.1097/00005650-198910000-00005. [DOI] [PubMed] [Google Scholar]
- Eley J. W., Hill H. A., Chen V. W., Austin D. F., Wesley M. N., Muss H. B., Greenberg R. S., Coates R. J., Correa P., Redmond C. K. Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study. JAMA. 1994 Sep 28;272(12):947–954. doi: 10.1001/jama.272.12.947. [DOI] [PubMed] [Google Scholar]
- Farrow D. C., Hunt W. C., Samet J. M. Geographic variation in the treatment of localized breast cancer. N Engl J Med. 1992 Apr 23;326(17):1097–1101. doi: 10.1056/NEJM199204233261701. [DOI] [PubMed] [Google Scholar]
- Fisher B., Bauer M., Margolese R., Poisson R., Pilch Y., Redmond C., Fisher E., Wolmark N., Deutsch M., Montague E. Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med. 1985 Mar 14;312(11):665–673. doi: 10.1056/NEJM198503143121101. [DOI] [PubMed] [Google Scholar]
- Fisher B., Costantino J., Redmond C., Fisher E., Margolese R., Dimitrov N., Wolmark N., Wickerham D. L., Deutsch M., Ore L. Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N Engl J Med. 1993 Jun 3;328(22):1581–1586. doi: 10.1056/NEJM199306033282201. [DOI] [PubMed] [Google Scholar]
- Fisher B., Redmond C., Poisson R., Margolese R., Wolmark N., Wickerham L., Fisher E., Deutsch M., Caplan R., Pilch Y. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989 Mar 30;320(13):822–828. doi: 10.1056/NEJM198903303201302. [DOI] [PubMed] [Google Scholar]
- Flood A. B., Scott W. R., Ewy W. Does practice make perfect? Part I: The relation between hospital volume and outcomes for selected diagnostic categories. Med Care. 1984 Feb;22(2):98–114. [PubMed] [Google Scholar]
- Greenfield S., Blanco D. M., Elashoff R. M., Ganz P. A. Patterns of care related to age of breast cancer patients. JAMA. 1987 May 22;257(20):2766–2770. [PubMed] [Google Scholar]
- HILL A. B. THE ENVIRONMENT AND DISEASE: ASSOCIATION OR CAUSATION? Proc R Soc Med. 1965 May;58:295–300. doi: 10.1177/003591576505800503. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hannan E. L., O'Donnell J. F., Kilburn H., Jr, Bernard H. R., Yazici A. Investigation of the relationship between volume and mortality for surgical procedures performed in New York State hospitals. JAMA. 1989 Jul 28;262(4):503–510. [PubMed] [Google Scholar]
- Hughes R. G., Hunt S. S., Luft H. S. Effects of surgeon volume and hospital volume on quality of care in hospitals. Med Care. 1987 Jun;25(6):489–503. doi: 10.1097/00005650-198706000-00004. [DOI] [PubMed] [Google Scholar]
- Lazovich D. A., White E., Thomas D. B., Moe R. E. Underutilization of breast-conserving surgery and radiation therapy among women with stage I or II breast cancer. JAMA. 1991 Dec 25;266(24):3433–3438. [PubMed] [Google Scholar]
- Lee-Feldstein A., Anton-Culver H., Feldstein P. J. Treatment differences and other prognostic factors related to breast cancer survival. Delivery systems and medical outcomes. JAMA. 1994 Apr 20;271(15):1163–1168. [PubMed] [Google Scholar]
- Luft H. S., Hunt S. S., Maerki S. C. The volume-outcome relationship: practice-makes-perfect or selective-referral patterns? Health Serv Res. 1987 Jun;22(2):157–182. [PMC free article] [PubMed] [Google Scholar]
- Nattinger A. B., Gottlieb M. S., Veum J., Yahnke D., Goodwin J. S. Geographic variation in the use of breast-conserving treatment for breast cancer. N Engl J Med. 1992 Apr 23;326(17):1102–1107. doi: 10.1056/NEJM199204233261702. [DOI] [PubMed] [Google Scholar]
- Samet J. M., Hunt W. C., Farrow D. C. Determinants of receiving breast-conserving surgery. The Surveillance, Epidemiology, and End Results Program, 1983-1986. Cancer. 1994 May 1;73(9):2344–2351. doi: 10.1002/1097-0142(19940501)73:9<2344::aid-cncr2820730917>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
- Satariano W. A., Ragland D. R. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med. 1994 Jan 15;120(2):104–110. doi: 10.7326/0003-4819-120-2-199401150-00002. [DOI] [PubMed] [Google Scholar]
- Spiegel D., Bloom J. R., Kraemer H. C., Gottheil E. Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet. 1989 Oct 14;2(8668):888–891. doi: 10.1016/s0140-6736(89)91551-1. [DOI] [PubMed] [Google Scholar]
- Veronesi U., Luini A., Del Vecchio M., Greco M., Galimberti V., Merson M., Rilke F., Sacchini V., Saccozzi R., Savio T. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 1993 Jun 3;328(22):1587–1591. doi: 10.1056/NEJM199306033282202. [DOI] [PubMed] [Google Scholar]