Skip to main content
American Journal of Public Health logoLink to American Journal of Public Health
. 1998 Oct;88(10):1481–1483. doi: 10.2105/ajph.88.10.1481

Ex-smokers and risk of hip fracture.

L Forsén 1, K Bjartveit 1, A Bjørndal 1, T H Edna 1, H E Meyer 1, B Schei 1
PMCID: PMC1508466  PMID: 9772848

Abstract

OBJECTIVES: The purpose of this study was to examine the reversibility of the effect of smoking on hip fracture incidence rates. METHODS: A 3-year follow-up cohort study was conducted involving 35,767 adults 50 years of age or older. Of these individuals, 421 suffered a hip fracture. RESULTS: Among participants less than 75 years of age, the relative risk (RR) of hip fracture was elevated for ex-smokers, even for those who had quit smoking more than 5 years previously (men: RR = 4.4, 95% confidence interval [CI] = 1.2, 15.3; women: RR = 1.3, 95% CI = 0.6, 3.0), but was not as high as that for current smokers (men: RR = 5.0, 95% CI = 1.5, 16.9; women: RR = 1.9, 95% CI = 1.2, 3.1). CONCLUSIONS: The effect of smoking on risk of hip fracture was not reversed completely 5 years after smoking cessation.

Full text

PDF
1481

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron J. A., La Vecchia C., Levi F. The antiestrogenic effect of cigarette smoking in women. Am J Obstet Gynecol. 1990 Feb;162(2):502–514. doi: 10.1016/0002-9378(90)90420-c. [DOI] [PubMed] [Google Scholar]
  2. Briggs M. H. Cigarette smoking and infertility in men. Med J Aust. 1973 Mar 24;1(12):616–617. doi: 10.5694/j.1326-5377.1973.tb110580.x. [DOI] [PubMed] [Google Scholar]
  3. Cooper C., Barker D. J., Wickham C. Physical activity, muscle strength, and calcium intake in fracture of the proximal femur in Britain. BMJ. 1988 Dec 3;297(6661):1443–1446. doi: 10.1136/bmj.297.6661.1443. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cumming R. G., Klineberg R. J. Case-control study of risk factors for hip fractures in the elderly. Am J Epidemiol. 1994 Mar 1;139(5):493–503. doi: 10.1093/oxfordjournals.aje.a117032. [DOI] [PubMed] [Google Scholar]
  5. Cummings S. R., Nevitt M. C., Browner W. S., Stone K., Fox K. M., Ensrud K. E., Cauley J., Black D., Vogt T. M. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1995 Mar 23;332(12):767–773. doi: 10.1056/NEJM199503233321202. [DOI] [PubMed] [Google Scholar]
  6. Drinkwater B. L., Bruemner B., Chesnut C. H., 3rd Menstrual history as a determinant of current bone density in young athletes. JAMA. 1990 Jan 26;263(4):545–548. [PubMed] [Google Scholar]
  7. Forsén L., Bjørndal A., Bjartveit K., Edna T. H., Holmen J., Jessen V., Westberg G. Interaction between current smoking, leanness, and physical inactivity in the prediction of hip fracture. J Bone Miner Res. 1994 Nov;9(11):1671–1678. doi: 10.1002/jbmr.5650091102. [DOI] [PubMed] [Google Scholar]
  8. Holmen J., Midthjell K., Forsén L., Skjerve K., Gorseth M., Oseland A. Helseundersøkelsen i Nord-Trøndelag 1984-86. Fremmøtet og sammenlikning av dem som møtte og dem som ikke møtte. Tidsskr Nor Laegeforen. 1990 Jun 10;110(15):1973–1977. [PubMed] [Google Scholar]
  9. Johnston C. C., Jr, Hui S. L., Witt R. M., Appledorn R., Baker R. S., Longcope C. Early menopausal changes in bone mass and sex steroids. J Clin Endocrinol Metab. 1985 Nov;61(5):905–911. doi: 10.1210/jcem-61-5-905. [DOI] [PubMed] [Google Scholar]
  10. Law M. R., Hackshaw A. K. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997 Oct 4;315(7112):841–846. doi: 10.1136/bmj.315.7112.841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MacMahon B., Trichopoulos D., Cole P., Brown J. Cigarette smoking and urinary estrogens. N Engl J Med. 1982 Oct 21;307(17):1062–1065. doi: 10.1056/NEJM198210213071707. [DOI] [PubMed] [Google Scholar]
  12. Manolagas S. C., Bellido T., Jilka R. L. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. Int J Immunopharmacol. 1995 Feb;17(2):109–116. doi: 10.1016/0192-0561(94)00089-7. [DOI] [PubMed] [Google Scholar]
  13. Meyer H. E., Tverdal A., Falch J. A. Risk factors for hip fracture in middle-aged Norwegian women and men. Am J Epidemiol. 1993 Jun 1;137(11):1203–1211. doi: 10.1093/oxfordjournals.aje.a116622. [DOI] [PubMed] [Google Scholar]
  14. Oursler M. J., Pederson L., Fitzpatrick L., Riggs B. L., Spelsberg T. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5227–5231. doi: 10.1073/pnas.91.12.5227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Paganini-Hill A., Chao A., Ross R. K., Henderson B. E. Exercise and other factors in the prevention of hip fracture: the Leisure World study. Epidemiology. 1991 Jan;2(1):16–25. doi: 10.1097/00001648-199101000-00004. [DOI] [PubMed] [Google Scholar]
  16. Schot L. P., Schuurs A. H. Sex steroids and osteoporosis: effects of deficiencies and substitutive treatments. J Steroid Biochem Mol Biol. 1990 Oct;37(2):167–182. doi: 10.1016/0960-0760(90)90325-f. [DOI] [PubMed] [Google Scholar]
  17. Shaarawy M., Mahmoud K. Z. Endocrine profile and semen characteristics in male smokers. Fertil Steril. 1982 Aug;38(2):255–257. doi: 10.1016/s0015-0282(16)46470-8. [DOI] [PubMed] [Google Scholar]
  18. Sofikitis N., Miyagawa I., Dimitriadis D., Zavos P., Sikka S., Hellstrom W. Effects of smoking on testicular function, semen quality and sperm fertilizing capacity. J Urol. 1995 Sep;154(3):1030–1034. [PubMed] [Google Scholar]
  19. Vanderschueren D. Androgens and their role in skeletal homeostasis. Horm Res. 1996;46(2):95–98. doi: 10.1159/000185003. [DOI] [PubMed] [Google Scholar]
  20. Vanderschueren D., Jans I., van Herck E., Moermans K., Verhaeghe J., Bouillon R. Time-related increase of biochemical markers of bone turnover in androgen-deficient male rats. Bone Miner. 1994 Aug;26(2):123–131. doi: 10.1016/s0169-6009(08)80057-8. [DOI] [PubMed] [Google Scholar]
  21. la Vecchia C., Negri E., Levi F., Baron J. A. Cigarette smoking, body mass and other risk factors for fractures of the hip in women. Int J Epidemiol. 1991 Sep;20(3):671–677. doi: 10.1093/ije/20.3.671. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

RESOURCES