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. 1999 Jan;89(1):90–92. doi: 10.2105/ajph.89.1.90

Deaths attributable to Alzheimer's disease in the United States.

D C Ewbank 1
PMCID: PMC1508512  PMID: 9987474

Abstract

OBJECTIVES: This study provided 2 estimates of the number of deaths attributable to Alzheimer's disease in the United States. METHODS: One estimate was based on data from the East Boston, Mass, study. The second was based on a simulation using population-based estimates of prevalence and separate estimates of excess death by duration of disease. RESULTS: Despite different methods and very different estimates of prevalence, these 2 methods led to very similar estimates of 173,000 and 163,000 excess deaths. CONCLUSIONS: These estimates suggest that 7.1% of all deaths in the United States in 1995 are attributable to Alzheimer's disease, placing it on a par with cerebrovascular diseases as the third leading cause of death.

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Selected References

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  1. Barclay L. L., Zemcov A., Blass J. P., Sansone J. Survival in Alzheimer's disease and vascular dementias. Neurology. 1985 Jun;35(6):834–840. doi: 10.1212/wnl.35.6.834. [DOI] [PubMed] [Google Scholar]
  2. Beckett L. A., Scherr P. A., Evans D. A. Population prevalence estimates from complex samples. J Clin Epidemiol. 1992 Apr;45(4):393–402. doi: 10.1016/0895-4356(92)90040-t. [DOI] [PubMed] [Google Scholar]
  3. Berg L., Miller J. P., Baty J., Rubin E. H., Morris J. C., Figiel G. Mild senile dementia of the Alzheimer type. 4. Evaluation of intervention. Ann Neurol. 1992 Mar;31(3):242–249. doi: 10.1002/ana.410310303. [DOI] [PubMed] [Google Scholar]
  4. Bowen J. D., Malter A. D., Sheppard L., Kukull W. A., McCormick W. C., Teri L., Larson E. B. Predictors of mortality in patients diagnosed with probable Alzheimer's disease. Neurology. 1996 Aug;47(2):433–439. doi: 10.1212/wnl.47.2.433. [DOI] [PubMed] [Google Scholar]
  5. Diesfeldt H. F., van Houte L. R., Moerkens R. M. Duration of survival in senile dementia. Acta Psychiatr Scand. 1986 Apr;73(4):366–371. doi: 10.1111/j.1600-0447.1986.tb02697.x. [DOI] [PubMed] [Google Scholar]
  6. Ebly E. M., Parhad I. M., Hogan D. B., Fung T. S. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology. 1994 Sep;44(9):1593–1600. doi: 10.1212/wnl.44.9.1593. [DOI] [PubMed] [Google Scholar]
  7. Evans D. A., Funkenstein H. H., Albert M. S., Scherr P. A., Cook N. R., Chown M. J., Hebert L. E., Hennekens C. H., Taylor J. O. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 1989 Nov 10;262(18):2551–2556. [PubMed] [Google Scholar]
  8. Evans D. A., Smith L. A., Scherr P. A., Albert M. S., Funkenstein H. H., Hebert L. E. Risk of death from Alzheimer's disease in a community population of older persons. Am J Epidemiol. 1991 Aug 15;134(4):403–412. doi: 10.1093/oxfordjournals.aje.a116102. [DOI] [PubMed] [Google Scholar]
  9. Fox P. From senility to Alzheimer's disease: the rise of the Alzheimer's disease movement. Milbank Q. 1989;67(1):58–102. [PubMed] [Google Scholar]
  10. Hendrie H. C., Osuntokun B. O., Hall K. S., Ogunniyi A. O., Hui S. L., Unverzagt F. W., Gureje O., Rodenberg C. A., Baiyewu O., Musick B. S. Prevalence of Alzheimer's disease and dementia in two communities: Nigerian Africans and African Americans. Am J Psychiatry. 1995 Oct;152(10):1485–1492. doi: 10.1176/ajp.152.10.1485. [DOI] [PubMed] [Google Scholar]
  11. Heyman A., Fillenbaum G., Prosnitz B., Raiford K., Burchett B., Clark C. Estimated prevalence of dementia among elderly black and white community residents. Arch Neurol. 1991 Jun;48(6):594–598. doi: 10.1001/archneur.1991.00530180046016. [DOI] [PubMed] [Google Scholar]
  12. Hoyert D. L. Mortality trends for Alzheimer's disease, 1979-91. Vital Health Stat 20. 1996 Jan;(28):1–23. [PubMed] [Google Scholar]
  13. Kestenbaum B. A description of the extreme aged population based on improved Medicare enrollment data. Demography. 1992 Nov;29(4):565–580. [PubMed] [Google Scholar]
  14. Letenneur L., Commenges D., Dartigues J. F., Barberger-Gateau P. Incidence of dementia and Alzheimer's disease in elderly community residents of south-western France. Int J Epidemiol. 1994 Dec;23(6):1256–1261. doi: 10.1093/ije/23.6.1256. [DOI] [PubMed] [Google Scholar]
  15. Manton K. G., Stallard E. Maximum likelihood estimation of a stochastic compartment model of cancer latency: lung cancer mortality among white females in the U.S. Comput Biomed Res. 1979 Aug;12(4):313–325. doi: 10.1016/0010-4809(79)90043-0. [DOI] [PubMed] [Google Scholar]
  16. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984 Jul;34(7):939–944. doi: 10.1212/wnl.34.7.939. [DOI] [PubMed] [Google Scholar]
  17. Mölsä P. K., Marttila R. J., Rinne U. K. Long-term survival and predictors of mortality in Alzheimer's disease and multi-infarct dementia. Acta Neurol Scand. 1995 Mar;91(3):159–164. doi: 10.1111/j.1600-0404.1995.tb00426.x. [DOI] [PubMed] [Google Scholar]
  18. Rocca W. A., Bonaiuto S., Lippi A., Luciani P., Turtù F., Cavarzeran F., Amaducci L. Prevalence of clinically diagnosed Alzheimer's disease and other dementing disorders: a door-to-door survey in Appignano, Macerata Province, Italy. Neurology. 1990 Apr;40(4):626–631. doi: 10.1212/wnl.40.4.626. [DOI] [PubMed] [Google Scholar]
  19. Rocca W. A., Hofman A., Brayne C., Breteler M. M., Clarke M., Copeland J. R., Dartigues J. F., Engedal K., Hagnell O., Heeren T. J. Frequency and distribution of Alzheimer's disease in Europe: a collaborative study of 1980-1990 prevalence findings. The EURODEM-Prevalence Research Group. Ann Neurol. 1991 Sep;30(3):381–390. doi: 10.1002/ana.410300310. [DOI] [PubMed] [Google Scholar]
  20. Skoog I., Nilsson L., Palmertz B., Andreasson L. A., Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med. 1993 Jan 21;328(3):153–158. doi: 10.1056/NEJM199301213280301. [DOI] [PubMed] [Google Scholar]
  21. Sobel E., Louhija J., Sulkava R., Davanipour Z., Kontula K., Miettinen H., Tikkanen M., Kainulainen K., Tilvis R. Lack of association of apolipoprotein E allele epsilon 4 with late-onset Alzheimer's disease among Finnish centenarians. Neurology. 1995 May;45(5):903–907. doi: 10.1212/wnl.45.5.903. [DOI] [PubMed] [Google Scholar]
  22. Walsh J. S., Welch H. G., Larson E. B. Survival of outpatients with Alzheimer-type dementia. Ann Intern Med. 1990 Sep 15;113(6):429–434. doi: 10.7326/0003-4819-113-6-429. [DOI] [PubMed] [Google Scholar]

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