Skip to main content
NCBI home page
American Journal of Public Health logoLink to American Journal of Public Health
. 1999 Mar;89(3):383–385. doi: 10.2105/ajph.89.3.383

Relationship of lipoprotein(a) levels to physical activity and family history of coronary heart disease.

S Martín 1, R Elosua 1, M I Covas 1, M Pavesi 1, J Vila 1, J Marrugat 1
PMCID: PMC1508607  PMID: 10076490

Abstract

OBJECTIVES: This study evaluated the association of physical activity with serum lipoprotein(a) [La(a)] levels in individuals according to whether they had a family history of coronary heart disease (CHD). METHODS: Lp(a) levels in 332 healthy Spanish men aged 20 to 60 years were measured. Physical activity and family history of CHD were assessed. RESULTS: For men with a family history of CHD, the odds ratio for Lp(a) levels above the median value was 0.13 (95% confidence interval = 0.03, 0.50) in very active men (energy expended in physical activity > 300 kcal/day) compared with active men (energy expended in physical activity < 300 kcal/day). CONCLUSIONS: Regular daily physical activity in individuals with a family history of CHD could be useful for controlling Lp(a) levels.

Full text

PDF
383

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ambrosio M. R., Valentini A., Trasforini G., Minuto F., Ghigo E., Cella S., Margutti A., Pansini R., degli Uberti E. C. Function of the GH/IGF-1 axis in healthy middle-aged male runners. Neuroendocrinology. 1996 Jun;63(6):498–503. doi: 10.1159/000127078. [DOI] [PubMed] [Google Scholar]
  2. Boerwinkle E., Leffert C. C., Lin J., Lackner C., Chiesa G., Hobbs H. H. Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest. 1992 Jul;90(1):52–60. doi: 10.1172/JCI115855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Buemann B., Tremblay A. Effects of exercise training on abdominal obesity and related metabolic complications. Sports Med. 1996 Mar;21(3):191–212. doi: 10.2165/00007256-199621030-00004. [DOI] [PubMed] [Google Scholar]
  4. Chico A., Pérez A., Caixàs A., Ordóez J., Pou J. M., de Leiva A. Lipoprotein(a) concentrations and non-insulin-dependent diabetes mellitus: relationship to glycaemic control and diabetic complications. Diabetes Res Clin Pract. 1996 Jul;33(2):105–110. doi: 10.1016/0168-8227(96)01285-5. [DOI] [PubMed] [Google Scholar]
  5. Duell P. B., Hagemenas F., Connor W. E. The relationship between serum lipoprotein(a) and insulinemia in healthy nondiabetic adult men. Diabetes Care. 1994 Oct;17(10):1135–1140. doi: 10.2337/diacare.17.10.1135. [DOI] [PubMed] [Google Scholar]
  6. Elosua R., Marrugat J., Molina L., Pons S., Pujol E. Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish men. The MARATHOM Investigators. Am J Epidemiol. 1994 Jun 15;139(12):1197–1209. doi: 10.1093/oxfordjournals.aje.a116966. [DOI] [PubMed] [Google Scholar]
  7. Fletcher G. F., Balady G., Blair S. N., Blumenthal J., Caspersen C., Chaitman B., Epstein S., Sivarajan Froelicher E. S., Froelicher V. F., Pina I. L. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation. 1996 Aug 15;94(4):857–862. doi: 10.1161/01.cir.94.4.857. [DOI] [PubMed] [Google Scholar]
  8. Gazzaruso C., Buscaglia P., Garzaniti A., Bonetti G., Savino S., Mariotti S., Jucci A., Finardi G., Geroldi D. Lipoprotein(a) plasma concentrations, apolipoprotein (a) polymorphism and family history of coronary heart disease in patients with essential hypertension. J Cardiovasc Risk. 1996 Apr;3(2):191–197. [PubMed] [Google Scholar]
  9. Guazzelli R., Fatini C., Piazzini M., Lazzeri C. Lipoproteina(a): marker genetico di infarto miocardico precoce. Ann Ital Med Int. 1996 Apr-Jun;11(2):90–94. [PubMed] [Google Scholar]
  10. Holme I., Urdal P., Anderssen S., Hjermann I. Exercise-induced increase in lipoprotein (a). Atherosclerosis. 1996 Apr 26;122(1):97–104. doi: 10.1016/0021-9150(95)05761-7. [DOI] [PubMed] [Google Scholar]
  11. Hubinger L., Mackinnon L. T., Lepre F. Lipoprotein(a) [Lp(a)] levels in middle-aged male runners and sedentary controls. Med Sci Sports Exerc. 1995 Apr;27(4):490–496. [PubMed] [Google Scholar]
  12. Jenner J. L., Ordovas J. M., Lamon-Fava S., Schaefer M. M., Wilson P. W., Castelli W. P., Schaefer E. J. Effects of age, sex, and menopausal status on plasma lipoprotein(a) levels. The Framingham Offspring Study. Circulation. 1993 Apr;87(4):1135–1141. doi: 10.1161/01.cir.87.4.1135. [DOI] [PubMed] [Google Scholar]
  13. Marrugat J., Elosua R., Covas M. I., Molina L., Rubiés-Prat J. Amount and intensity of physical activity, physical fitness, and serum lipids in men. The MARATHOM Investigators. Am J Epidemiol. 1996 Mar 15;143(6):562–569. doi: 10.1093/oxfordjournals.aje.a008786. [DOI] [PubMed] [Google Scholar]
  14. Massod M. F. Nonparametric percentile estimate of clinical normal ranges. Am J Med Technol. 1977 Mar;43(3):243–252. [PubMed] [Google Scholar]
  15. Olivecrona H., Johansson A. G., Lindh E., Ljunghall S., Berglund L., Angelin B. Hormonal regulation of serum lipoprotein(a) levels. Contrasting effects of growth hormone and insulin-like growth factor-I. Arterioscler Thromb Vasc Biol. 1995 Jul;15(7):847–849. doi: 10.1161/01.atv.15.7.847. [DOI] [PubMed] [Google Scholar]
  16. Paffenbarger R. S., Jr, Wing A. L., Hyde R. T. Physical activity as an index of heart attack risk in college alumni. Am J Epidemiol. 1978 Sep;108(3):161–175. doi: 10.1093/oxfordjournals.aje.a112608. [DOI] [PubMed] [Google Scholar]
  17. Rosengren A., Wilhelmsen L., Eriksson E., Risberg B., Wedel H. Lipoprotein (a) and coronary heart disease: a prospective case-control study in a general population sample of middle aged men. BMJ. 1990 Dec 1;301(6763):1248–1251. doi: 10.1136/bmj.301.6763.1248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Routi T., Rönnemaa T., Jokinen E., Viikari J., Niinikoski H., Leino A., Simell O. Correlation of toddlers' serum lipoprotein(a) concentration with parental values and grandparents' coronary heart disease: the STRIP baby study. Acta Paediatr. 1996 Apr;85(4):407–412. doi: 10.1111/j.1651-2227.1996.tb14051.x. [DOI] [PubMed] [Google Scholar]
  19. Taylor H. L., Jacobs D. R., Jr, Schucker B., Knudsen J., Leon A. S., Debacker G. A questionnaire for the assessment of leisure time physical activities. J Chronic Dis. 1978;31(12):741–755. doi: 10.1016/0021-9681(78)90058-9. [DOI] [PubMed] [Google Scholar]

Articles from American Journal of Public Health are provided here courtesy of American Public Health Association

RESOURCES