Abstract
Different areas of the hypothalamus were stimulated by a stereotaxic technique before and after reserpine in unanaesthetized cats. Reserpine in a dose of 1 mg./kg. body weight increased the threshold of stimulation of hypothalamic areas in cats giving an initial pressor response. It decreased the threshold of stimulation of areas of the hypothalamus in animals giving an initial depressor response. Reserpine thus appeared to affect the hypothalamus directly in two ways. It depressed the sympathetic centres in the diencephalon and facilitated the parasympathetic ones.
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Selected References
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- BEIN H. J. Zur Pharmakologie des Reserpin, eines neuen Alkaloids aus Rauwolfia serpentina Benth. Experientia. 1953 Mar 15;9(3):107–110. doi: 10.1007/BF02178342. [DOI] [PubMed] [Google Scholar]
- BHARGAVA K. P., BORISON H. L. Effects of Rauwolfia alkaloids on hypothalamic, medullary and spinal vasoregulatory systems. J Pharmacol Exp Ther. 1955 Dec;115(4):464–479. [PubMed] [Google Scholar]
- DELGADO J. M. R., ANAND B. K. Increase of food intake induced by electrical stimulation of the lateral hypothalamus. Am J Physiol. 1953 Jan;172(1):162–168. doi: 10.1152/ajplegacy.1952.172.1.162. [DOI] [PubMed] [Google Scholar]
- DOYLE A. E., SMIRK F. H. Drug therapy in hypertension; a critical review. Practitioner. 1955 Feb;174(1040):135–143. [PubMed] [Google Scholar]
- RAY G. K., ROY P. K., DASGUPTA S. R., WERNER G. The action of Rauwolfia serpentina on vasomotor reflexes. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1953;219(4):310–314. doi: 10.1007/BF00246406. [DOI] [PubMed] [Google Scholar]
- SCHNEIDER J. A. Further characterization of central effects of reserpine (serpasil). Am J Physiol. 1955 Apr;181(1):64–68. doi: 10.1152/ajplegacy.1955.181.1.64. [DOI] [PubMed] [Google Scholar]
- TRAPOLD J. H., PLUMMER A. J., YONKMAN F. F. Cardiovascular and respiratory effects of serpasil, a new crystalline alkaloid from Rauwolfia serpentina Benth, in the dog. J Pharmacol Exp Ther. 1954 Feb;110(2):205–214. [PubMed] [Google Scholar]
- TRIPOD J., MEIER R. Wirkung von Serpasil (Reserpin, ein neues Alkaloid von Rauwolfia serpentina B.) auf isolierte Kreislauforgange. Arch Int Pharmacodyn Ther. 1954 Apr 1;97(3-4):251–266. [PubMed] [Google Scholar]
- VAKIL R. J. Rauwolfia serpentina in the treatment of high blood-pressure. Lancet. 1954 Oct 9;267(6841):726–727. doi: 10.1016/s0140-6736(54)90494-8. [DOI] [PubMed] [Google Scholar]