Abstract
The work of Gomes on the polypeptide in human urine which causes contraction of the rat uterus has been extended. Concentrates were prepared by means of paper pulp columns similar to those used by Rocha e Silva and his colleagues for the purification of bradykinin, and evidence was obtained for the presence of two different active substances not only in human urine but also in a preparation of bradykinin. The effect of human urine on the rat uterus is probably due to bradykinin itself or a mixture of similar substances.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ANDRADE S. O., DINIZ C. R., ROCHA E., SILVA M. Assay of purification of bradykinin by chromatography. Arch Int Pharmacodyn Ther. 1953 Aug;95(1):100–122. [PubMed] [Google Scholar]
- CLARK L. C., Jr, WINKLER C., GOLLAN F., FOX R. P. The extraction and purification of hypertension (angiotonin). J Biol Chem. 1954 Feb;206(2):717–724. [PubMed] [Google Scholar]
- Gaddum J. H., Peart W. S., Vogt M. The estimation of adrenaline and allied substances in blood. J Physiol. 1949 Jun 15;108(4):467–481. doi: 10.1113/jphysiol.1949.sp004350. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HAMBERG U., ROCHA E., SILVA M. Studies on the enzymatic inactivation of bradykinin. Acta Physiol Scand. 1954;30(2-3):215–225. doi: 10.1111/j.1748-1716.1954.tb01089.x. [DOI] [PubMed] [Google Scholar]
- WERLE E., ERDOS E. G. Uber eine neue blutdrucksenkende, darm- und uteruserregende Substanz im menschlichen Urin. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1954;223(3):234–243. [PubMed] [Google Scholar]