Abstract
Hypoxaemia, resulting from increased tissue metabolism, is an important factor in dinitrophenol failure in the conventional heart-lung preparation. Improved oxygenation of the blood by a technique described in this paper prolongs the life of dinitrophenol-treated hearts. Dinitrophenol acts very rapidly; oxygen consumption and coronary flow increase in a few minutes and the increase is proportional to the dose. The increase in oxygen consumption diminishes with time. Dinitrophenol decreases the phosphocreatine content of the heart, even when there is no failure or hypoxia. There is no evidence that dinitrophenol failure can be due to a decrease of phosphocreatine or adenosine triphosphate content of the heart, although this is to be expected in view of the observed “uncoupling” action of dinitrophenol.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BADEER H. Role of hypoxia in hypothermic cardiac arrest in the heart, lung preparation. Am J Physiol. 1955 Oct;183(1):119–120. doi: 10.1152/ajplegacy.1955.183.1.119. [DOI] [PubMed] [Google Scholar]
- FAWAZ G., HAWA E. S., TUTUNJI B. The effect of dinitrophenol, hypoxaemia and ischaemia on the phosphorus compounds of the dog heart. Br J Pharmacol Chemother. 1957 Sep;12(3):270–272. doi: 10.1111/j.1476-5381.1957.tb00133.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GRUHZIT C. C., FARAH A. E. A comparison of the positive inotropic effects of ouabain and epinephrine in heart failure induced in the dog heart-lung preparation by sodium pentobarbital, dinitrophenol, sodium cyanide and sodium azide. J Pharmacol Exp Ther. 1955 Jul;114(3):334–342. [PubMed] [Google Scholar]
- RODBARD S., GRAHAM G. R., WILLIAMS F. Continuous and simultaneous measurement of total coronary flow, venous return and cardiac output in the dog. J Appl Physiol. 1953 Nov;6(5):311–314. doi: 10.1152/jappl.1953.6.5.311. [DOI] [PubMed] [Google Scholar]
- ROTHLIN E., TAESCHLER M., CERLETTI A. Action of dinitrophenol and lanatoside C on the canine heart-lung preparation. Circ Res. 1955 Jan;3(1):32–38. doi: 10.1161/01.res.3.1.32. [DOI] [PubMed] [Google Scholar]