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. 1994 Oct;113(2):342–344. doi: 10.1111/j.1476-5381.1994.tb16992.x

Sustained prejunctional facilitation of noradrenergic neurotransmission by adrenaline as a co-transmitter in the portal vein of freely moving rats.

R P Coppes 1, F Brouwer 1, I Freie 1, J Smit 1, J Zaagsma 1
PMCID: PMC1510130  PMID: 7834181

Abstract

1. The duration of the facilitatory effect of adrenaline on the electrically evoked overflow of noradrenaline was studied in the portal vein of permanently adreno-demedullated freely moving rats. 2. Rats were infused with adrenaline (20 or 100 ng min-1) for 2 h. After an interval of 1 h, when plasma adrenaline had returned to undetectable levels, electrical stimulation resulted in an enhanced catecholamine overflow amounting to 219% (noradrenaline) and 241% (noradrenaline plus adrenaline) of control (saline infusion), respectively. 3. When stimulation was applied again, in the same animal, at 24, 48 and 72 h after the first stimulation episode, the evoked noradrenaline overflow was 150, 111 and 102% (after 20 ng ml-1 adrenaline) and 158, 134 and 105% (after 100 ng min-1 adrenaline) of control. 4. The beta 2-adrenoceptor antagonist, ICI 118,551 (0.3 mg kg-1), blocked the facilitatory effect obtained after the 100 ng min-1 adrenaline infusion on all days. 5. The results show that adrenaline, after being taken up by and released from sympathetic nerve terminals, is able to facilitate the evoked noradrenaline overflow through activation of prejunctional beta 2-adrenoceptors for at least 48 h after administration.

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Selected References

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  1. Blankestijn P. J., Tulen J., Man in 't Veld A. J., Boomsma F., Schalekamp M. A. 'Stress' levels of adrenaline mediate a protracted amplification of the blood pressure response to sympathetic stimulation in man. J Hypertens Suppl. 1991 Dec;9(6):S76–S77. [PubMed] [Google Scholar]
  2. Borkowski K. R. Effect of adrenal demedullation and adrenaline on hypertension development and vascular reactivity in young spontaneously hypertensive rats. J Auton Pharmacol. 1991 Feb;11(1):1–14. doi: 10.1111/j.1474-8673.1991.tb00239.x. [DOI] [PubMed] [Google Scholar]
  3. Borkowski K. R., Quinn P. Adrenaline and the development of spontaneous hypertension in rats. J Auton Pharmacol. 1985 Jun;5(2):89–100. doi: 10.1111/j.1474-8673.1985.tb00109.x. [DOI] [PubMed] [Google Scholar]
  4. Coppes R. P., Smit J., Khali N. N., Brouwer F., Zaagsma J. Strong activation of vascular prejunctional beta 2-adrenoceptors in freely moving rats by adrenaline released as a co-transmitter. Eur J Pharmacol. 1993 Oct 26;243(3):273–279. doi: 10.1016/0014-2999(93)90185-k. [DOI] [PubMed] [Google Scholar]
  5. Eisenhofer G., Smolich J. J., Esler M. D. Disposition of endogenous adrenaline compared to noradrenaline released by cardiac sympathetic nerves in the anaesthetized dog. Naunyn Schmiedebergs Arch Pharmacol. 1992 Feb;345(2):160–171. doi: 10.1007/BF00165731. [DOI] [PubMed] [Google Scholar]
  6. Ferreira S. H., Vane J. R. Half-lives of peptides and amines in the circulation. Nature. 1967 Sep 16;215(5107):1237–1240. doi: 10.1038/2151237a0. [DOI] [PubMed] [Google Scholar]
  7. Floras J. S. Epinephrine and the genesis of hypertension. Hypertension. 1992 Jan;19(1):1–18. doi: 10.1161/01.hyp.19.1.1. [DOI] [PubMed] [Google Scholar]
  8. Kvetnanský R., Goldstein D. S., Weise V. K., Holmes C., Szemeredi K., Bagdy G., Kopin I. J. Effects of handling or immobilization on plasma levels of 3,4-dihydroxyphenylalanine, catecholamines, and metabolites in rats. J Neurochem. 1992 Jun;58(6):2296–2302. doi: 10.1111/j.1471-4159.1992.tb10977.x. [DOI] [PubMed] [Google Scholar]
  9. Majewski H., Rand M. J., Tung L. H. Activation of prejunctional beta-adrenoceptors in rat atria by adrenaline applied exogenously or released as a co-transmitter. Br J Pharmacol. 1981 Jul;73(3):669–679. doi: 10.1111/j.1476-5381.1981.tb16802.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Remie R., Knot H. J., Kolker H. J., Zaagsma J. Pronounced facilitation of endogenous noradrenaline release by presynaptic beta 2-adrenoceptors in the vasculature of freely moving rats. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):215–220. doi: 10.1007/BF00173390. [DOI] [PubMed] [Google Scholar]
  11. Remie R., Van Rossum J. X., Coppes R. P., Zaagsma J. Dysfunctional presynaptic alpha 2-adrenoceptors expose facilitatory beta 2-adrenoceptors in the vasculature of spontaneously hypertensive rats. Eur J Pharmacol. 1992 Feb 11;211(2):257–261. doi: 10.1016/0014-2999(92)90537-e. [DOI] [PubMed] [Google Scholar]

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