Abstract
A method is described for the assessment of the local reaction produced by intramuscular injections. This method involves the histological examinations of the injection site after injection of material into the hamstring muscles of the rat. The results obtained with both aqueous and oily materials are described; the correlation of these results with clinical observations in man is discussed.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ADAMS R. D., WALTON J. N. The response of the normal, the denervated and the dystrophic muscle-cell to injury. J Pathol Bacteriol. 1956 Jul;72(1):273–298. doi: 10.1002/path.1700720134. [DOI] [PubMed] [Google Scholar]
- BERESFORD C. R., GOLBERG L., SMITH J. P. Local effects and mechanism of absorption of iron preparations administered intramuscularly. Br J Pharmacol Chemother. 1957 Mar;12(1):107–114. doi: 10.1111/j.1476-5381.1957.tb01371.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GLUCKERT H., BENOIT W. Zur Klinik und Pathologie der Sulfonamidschädigungen am peripheren Nervensystem. Nervenarzt. 1952 Jan;23(1):17–21. [PubMed] [Google Scholar]
- LUTHY F. Die Nervenschädigungen nach intraglutäaler Injektion von Irgapyrin und ein Vorschlag zu ihrer Verhütung. Schweiz Med Wochenschr. 1955 Nov 5;85(45):1092–concl. [PubMed] [Google Scholar]
- STORY P. Histological reactions to injections of procaine penicillin in oil. Br Med J. 1950 Jun 24;1(4668):1467–1468. doi: 10.1136/bmj.1.4668.1467. [DOI] [PMC free article] [PubMed] [Google Scholar]
- VON HOCHSTETTER A. Uber Probleme und Technik der intraglutäalen Injektion. I. Der Einfluss des Medikamentes und der Individualität des Patienten auf die Entstehung von Spritzenschäden. Schweiz Med Wochenschr. 1955 Nov 19;85(47):1138–1144. [PubMed] [Google Scholar]