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. 1996 Nov;75(5):432–435. doi: 10.1136/adc.75.5.432

Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin.

E J Estlin 1, R D Palmer 1, K P Windebank 1, M F Lowry 1, A D Pearson 1
PMCID: PMC1511773  PMID: 8957958

Abstract

Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of non-familial HLH.

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Selected References

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