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. 1996 Nov;75(5):363–365. doi: 10.1136/adc.75.5.363

Hepatitis C infection after blood product transfusion.

D A Kelly 1
PMCID: PMC1511780  PMID: 8957946

Abstract

HCV infection has been demonstrated in multiply transfused children who received blood products or transplanted organs before universal screening in 1990. The risk of active infection is related to the number of transfusions or pooled blood products. Accurate diagnosis of infection is dependent on utilisation of third generation RIBA and identification of HCV RNA by RT-PCR. The natural history of HCV in childhood is undetermined and prospective long term studies should be undertaken. It is likely that about develop chronic hepatitis with progression at some time to cirrhosis and have an increased risk of developing liver cancer. Treatment with interferon alfa may be effective in up to 50% of children and only those children with documented infection with HCV RNA should be selected for treatment. In order to answer important questions about natural history, outcome, and the necessity and efficacy of treatment response, treatment for these children should only be as part of scientifically conducted studies on a multicentre basis.

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Selected References

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  1. Abuaf N., Lunel F., Giral P., Borotto E., Laperche S., Poupon R., Opolon P., Huraux J. M., Homberg J. C. Non-organ specific autoantibodies associated with chronic C virus hepatitis. J Hepatol. 1993 Jul;18(3):359–364. doi: 10.1016/s0168-8278(05)80281-8. [DOI] [PubMed] [Google Scholar]
  2. Aricò M., Maggiore G., Silini E., Bono F., Viganò C., Cerino A., Mondelli M. U. Hepatitis C virus infection in children treated for acute lymphoblastic leukemia. Blood. 1994 Nov 1;84(9):2919–2922. [PubMed] [Google Scholar]
  3. Bortolotti F., Giacchino R., Vajro P., Barbera C., Crivellaro C., Alberti A., Nebbia G., Zancan L., De Moliner L., Bertolini A. Recombinant interferon-alfa therapy in children with chronic hepatitis C. Hepatology. 1995 Dec;22(6):1623–1627. [PubMed] [Google Scholar]
  4. Bortolotti F., Vajro P., Cadrobbi P., Lepore L., Zancan L., Barbera C., Crivellaro C., Fontanella A., Alberti A., D'Addezio M. Cryptogenic chronic liver disease and hepatitis C virus infection in children. J Hepatol. 1992 May;15(1-2):73–76. doi: 10.1016/0168-8278(92)90014-g. [DOI] [PubMed] [Google Scholar]
  5. Bruix J., Barrera J. M., Calvet X., Ercilla G., Costa J., Sanchez-Tapias J. M., Ventura M., Vall M., Bruguera M., Bru C. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989 Oct 28;2(8670):1004–1006. doi: 10.1016/s0140-6736(89)91015-5. [DOI] [PubMed] [Google Scholar]
  6. Cesaro S., Rossetti F., De Moliner L., Crivellaro C., Zanesco L., Bortolotti F. Interferon for chronic hepatitis C in patients cured of malignancy. Eur J Pediatr. 1994 Sep;153(9):659–662. doi: 10.1007/BF02190687. [DOI] [PubMed] [Google Scholar]
  7. Choo Q. L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989 Apr 21;244(4902):359–362. doi: 10.1126/science.2523562. [DOI] [PubMed] [Google Scholar]
  8. Clemente M. G., Congia M., Lai M. E., Lilliu F., Lampis R., Frau F., Frau M. R., Faa G., Diana G., Dessì C. Effect of iron overload on the response to recombinant interferon-alfa treatment in transfusion-dependent patients with thalassemia major and chronic hepatitis C. J Pediatr. 1994 Jul;125(1):123–128. doi: 10.1016/s0022-3476(94)70138-5. [DOI] [PubMed] [Google Scholar]
  9. Davis G. L., Balart L. A., Schiff E. R., Lindsay K., Bodenheimer H. C., Jr, Perrillo R. P., Carey W., Jacobson I. M., Payne J., Dienstag J. L. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial. Hepatitis Interventional Therapy Group. N Engl J Med. 1989 Nov 30;321(22):1501–1506. doi: 10.1056/NEJM198911303212203. [DOI] [PubMed] [Google Scholar]
  10. DeVault K. R., Friedman L. S., Westerberg S., Martin P., Hosein B., Ballas S. K. Hepatitis C in sickle cell anemia. J Clin Gastroenterol. 1994 Apr;18(3):206–209. doi: 10.1097/00004836-199404000-00006. [DOI] [PubMed] [Google Scholar]
  11. Di Bisceglie A. M., Martin P., Kassianides C., Lisker-Melman M., Murray L., Waggoner J., Goodman Z., Banks S. M., Hoofnagle J. H. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1989 Nov 30;321(22):1506–1510. doi: 10.1056/NEJM198911303212204. [DOI] [PubMed] [Google Scholar]
  12. Eyster M. E., Diamondstone L. S., Lien J. M., Ehmann W. C., Quan S., Goedert J. J. Natural history of hepatitis C virus infection in multitransfused hemophiliacs: effect of coinfection with human immunodeficiency virus. The Multicenter Hemophilia Cohort Study. J Acquir Immune Defic Syndr. 1993 Jun;6(6):602–610. [PubMed] [Google Scholar]
  13. Eyster M. E., Fried M. W., Di Bisceglie A. M., Goedert J. J. Increasing hepatitis C virus RNA levels in hemophiliacs: relationship to human immunodeficiency virus infection and liver disease. Multicenter Hemophilia Cohort Study. Blood. 1994 Aug 15;84(4):1020–1023. [PubMed] [Google Scholar]
  14. Fujii Y., Kaku K., Tanaka M., Kaneko T., Matumoto N., Shinohara K. Hepatitis C virus infection and liver disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1994 May;13(5):523–526. [PubMed] [Google Scholar]
  15. Gane E. J., Portmann B. C., Naoumov N. V., Smith H. M., Underhill J. A., Donaldson P. T., Maertens G., Williams R. Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med. 1996 Mar 28;334(13):815–820. doi: 10.1056/NEJM199603283341302. [DOI] [PubMed] [Google Scholar]
  16. Inui A., Fujisawa T., Miyagawa Y., Sekine I., Hanada R., Yamamoto K., Shiihara H., Inui M. Histologic activity of the liver in children with transfusion-associated chronic hepatitis C. J Hepatol. 1994 Nov;21(5):748–753. doi: 10.1016/s0168-8278(94)80234-3. [DOI] [PubMed] [Google Scholar]
  17. Iorio R., Guida S., Porzio S., Fariello I., Vegnente A. Chronic non-A, non-B hepatitis: role of hepatitis C virus. Arch Dis Child. 1993 Feb;68(2):219–222. doi: 10.1136/adc.68.2.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Iorio R., Pensati P., Porzio S., Fariello I., Guida S., Vegnente A. Lymphoblastoid interferon alfa treatment in chronic hepatitis C. Arch Dis Child. 1996 Feb;74(2):152–156. doi: 10.1136/adc.74.2.152. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Jeffers L. J., Hasan F., De Medina M., Reddy R., Parker T., Silva M., Mendez L., Schiff E. R., Manns M., Houghton M. Prevalence of antibodies to hepatitis C virus among patients with cryptogenic chronic hepatitis and cirrhosis. Hepatology. 1992 Feb;15(2):187–190. doi: 10.1002/hep.1840150204. [DOI] [PubMed] [Google Scholar]
  20. Kemper C. A., Havlir D., Haghighat D., Dubé M., Bartok A. E., Sison J. P., Yao Y., Yangco B., Leedom J. M., Tilles J. G. The individual microbiologic effect of three antimycobacterial agents, clofazimine, ethambutol, and rifampin, on Mycobacterium avium complex bacteremia in patients with AIDS. J Infect Dis. 1994 Jul;170(1):157–164. doi: 10.1093/infdis/170.1.157. [DOI] [PubMed] [Google Scholar]
  21. Kudesia G., Price C., Clewley J. Passively transfused hepatitis C antibody. Lancet. 1992 Nov 21;340(8830):1291–1291. doi: 10.1016/0140-6736(92)92994-q. [DOI] [PubMed] [Google Scholar]
  22. Lin H. H., Kao J. H., Hsu H. Y., Ni Y. H., Chang M. H., Huang S. C., Hwang L. H., Chen P. J., Chen D. S. Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers. J Pediatr. 1995 Apr;126(4):589–591. doi: 10.1016/s0022-3476(95)70356-x. [DOI] [PubMed] [Google Scholar]
  23. Ma Y., Peakman M., Lobo-Yeo A., Wen L., Lenzi M., Gäken J., Farzaneh F., Mieli-Vergani G., Bianchi F. B., Vergani D. Differences in immune recognition of cytochrome P4502D6 by liver kidney microsomal (LKM) antibody in autoimmune hepatitis and chronic hepatitis C virus infection. Clin Exp Immunol. 1994 Jul;97(1):94–99. doi: 10.1111/j.1365-2249.1994.tb06585.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Marino N., Di Pietro M., Moschitta P., Balocchini E., Chionne P., Spada E., Rapicetta M., Stroffolini T., Mazzotta F. Intrafamily spread of hepatitis C virus infection. New Microbiol. 1994 Apr;17(2):147–150. [PubMed] [Google Scholar]
  25. Matsuoka S., Tatara K., Hayabuchi Y., Nii M., Mori K., Kuroda Y. Post-transfusion chronic hepatitis C in children. J Paediatr Child Health. 1994 Dec;30(6):544–546. doi: 10.1111/j.1440-1754.1994.tb00731.x. [DOI] [PubMed] [Google Scholar]
  26. McHutchison J. G., Person J. L., Govindarajan S., Valinluck B., Gore T., Lee S. R., Nelles M., Polito A., Chien D., DiNello R. Improved detection of hepatitis C virus antibodies in high-risk populations. Hepatology. 1992 Jan;15(1):19–25. doi: 10.1002/hep.1840150105. [DOI] [PubMed] [Google Scholar]
  27. Meisel H., Reip A., Faltus B., Lu M., Porst H., Wiese M., Roggendorf M., Krüger D. H. Transmission of hepatitis C virus to children and husbands by women infected with contaminated anti-D immunoglobulin. Lancet. 1995 May 13;345(8959):1209–1211. doi: 10.1016/s0140-6736(95)91992-9. [DOI] [PubMed] [Google Scholar]
  28. Monteleone P. M., Andrzejewski C., Kelleher J. F. Prevalence of antibodies to hepatitis C virus in transfused children with cancer. Am J Pediatr Hematol Oncol. 1994 Nov;16(4):309–313. [PubMed] [Google Scholar]
  29. Naito M., Hayashi N., Hagiwara H., Hiramatsu N., Kasahara A., Fusamoto H., Kamada T. Serum hepatitis C virus RNA quantity and histological features of hepatitis C virus carriers with persistently normal ALT levels. Hepatology. 1994 Apr;19(4):871–875. [PubMed] [Google Scholar]
  30. Napoli N., Fiore G., Vella F., Fera G., Schiraldi O. Prevalence of antibodies to hepatitis C virus among family members of patients with chronic hepatitis C. Eur J Epidemiol. 1993 Nov;9(6):629–632. doi: 10.1007/BF00211437. [DOI] [PubMed] [Google Scholar]
  31. Nowicki M. J., Ahmad N., Heubi J. E., Kuramoto I. K., Baroudy B. M., Balistreri W. F. The prevalence of hepatitis C virus (HCV) in infants and children after liver transplantation. Dig Dis Sci. 1994 Oct;39(10):2250–2254. doi: 10.1007/BF02090380. [DOI] [PubMed] [Google Scholar]
  32. Orloff S. L., Stempel C. A., Wright T. L., Tomlanovich S. J., Amend W. J., Stock P. G., Melzer J. S., Vincenti F. Long-term outcome in kidney transplant patients with hepatitis C (HCV) infection. Clin Transplant. 1995 Apr;9(2):119–124. [PubMed] [Google Scholar]
  33. Oshita M., Hayashi N., Kasahara A., Yuki N., Takehara T., Hagiwara H., Hayakawa Y., Yasumatsuya Y., Kishida Y., Fusamoto H. Prevalence of hepatitis C virus in family members of patients with hepatitis C. J Med Virol. 1993 Nov;41(3):251–255. doi: 10.1002/jmv.1890410314. [DOI] [PubMed] [Google Scholar]
  34. Parvaz P., Guichard E., Chevallier P., Ritter J., Trepo C., Sepetjan M. Hepatitis C: description of a highly sensitive method for clinical detection of viral RNA. J Virol Methods. 1994 Apr;47(1-2):83–94. doi: 10.1016/0166-0934(94)90068-x. [DOI] [PubMed] [Google Scholar]
  35. Pastore M., Willems M., Cornu C., Buts J. P., Reding R., de Ville de Goyet J., Rahier J., Otte J. B., Yap S. H., Sokal E. M. Role of hepatitis C virus in chronic liver disease occurring after orthotopic liver transplantation. Arch Dis Child. 1995 May;72(5):403–407. doi: 10.1136/adc.72.5.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Read A. E., Donegan E., Lake J., Ferrell L., Galbraith C., Kuramoto I. K., Zeldis J. B., Ascher N. L., Roberts J., Wright T. L. Hepatitis C in liver transplant recipients. Transplant Proc. 1991 Feb;23(1 Pt 2):1504–1505. [PubMed] [Google Scholar]
  37. Resti M., Azzari C., Lega L., Rossi M. E., Zammarchi E., Novembre E., Vierucci A. Mother-to-infant transmission of hepatitis C virus. Acta Paediatr. 1995 Mar;84(3):251–255. doi: 10.1111/j.1651-2227.1995.tb13624.x. [DOI] [PubMed] [Google Scholar]
  38. Roudot-Thoraval F., Pawlotsky J. M., Thiers V., Deforges L., Girollet P. P., Guillot F., Huraux C., Aumont P., Brechot C., Dhumeaux D. Lack of mother-to-infant transmission of hepatitis C virus in human immunodeficiency virus-seronegative women: a prospective study with hepatitis C virus RNA testing. Hepatology. 1993 May;17(5):772–777. [PubMed] [Google Scholar]
  39. Ruiz-Moreno M., Rua M. J., Castillo I., García-Novo M. D., Santos M., Navas S., Carreño V. Treatment of children with chronic hepatitis C with recombinant interferon-alpha: a pilot study. Hepatology. 1992 Oct;16(4):882–885. doi: 10.1002/hep.1840160405. [DOI] [PubMed] [Google Scholar]
  40. Sakamoto N., Enomoto N., Marumo F., Sato C. Prevalence of hepatitis C virus infection among long-term hemodialysis patients: detection of hepatitis C virus RNA in plasma. J Med Virol. 1993 Jan;39(1):11–15. doi: 10.1002/jmv.1890390104. [DOI] [PubMed] [Google Scholar]
  41. Schlipköter U., Gladziwa U., Cholmakov K., Weise A., Rasshofer R., Lorbeer B., Luz N., Deinhardt F., Roggendorf M. Prevalence of hepatitis C virus infections in dialysis patients and their contacts using a second generation enzymed-linked immunosorbent assay. Med Microbiol Immunol. 1992;181(3):173–180. doi: 10.1007/BF00202057. [DOI] [PubMed] [Google Scholar]
  42. Shopnick R. I., Brettler D. B., Bolivar E. Hepatitis C virus transmission by monoclonal purified viral-attenuated factor VIII concentrate. Lancet. 1995 Sep 2;346(8975):645–645. doi: 10.1016/s0140-6736(95)91483-8. [DOI] [PubMed] [Google Scholar]
  43. Taliani G., Guerra E., Rosso R., Badolato M. C., Luzi G., Sacco G., Lecce R., De Bac C., Aiuti F. Hepatitis C virus infection in hypogammaglobulinemic patients receiving long-term replacement therapy with intravenous immunoglobulin. Transfusion. 1995 Feb;35(2):103–107. doi: 10.1046/j.1537-2995.1995.35295125730.x. [DOI] [PubMed] [Google Scholar]
  44. Tsubota A., Chayama K., Ikeda K., Yasuji A., Koida I., Saitoh S., Hashimoto M., Iwasaki S., Kobayashi M., Hiromitsu K. Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology. 1994 May;19(5):1088–1094. [PubMed] [Google Scholar]
  45. Wonke B., Donohue S. M., Hoffbrand A. V., Scheuer P. J., Brown D., Dusheiko G. Recombinant alpha 2B interferon (IFN) in the treatment of chronic hepatitis C disease in thalassaemia major (TM). Bone Marrow Transplant. 1993;12 (Suppl 1):24–25. [PubMed] [Google Scholar]
  46. Wright T. L., Donegan E., Hsu H. H., Ferrell L., Lake J. R., Kim M., Combs C., Fennessy S., Roberts J. P., Ascher N. L. Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology. 1992 Jul;103(1):317–322. doi: 10.1016/0016-5085(92)91129-r. [DOI] [PubMed] [Google Scholar]
  47. al-Mahroos F. T., Ebrahim A. Prevalence of hepatitis B, hepatitis C and human immune deficiency virus markers among patients with hereditary haemolytic anaemias. Ann Trop Paediatr. 1995 Jun;15(2):121–128. doi: 10.1080/02724936.1995.11747759. [DOI] [PubMed] [Google Scholar]
  48. el Gohary A., Hassan A., Nooman Z., Lavanchy D., Mayerat C., el Ayat A., Fawaz N., Gobran F., Ahmed M., Kawano F. High prevalence of hepatitis C virus among urban and rural population groups in Egypt. Acta Trop. 1995 May;59(2):155–161. doi: 10.1016/0001-706x(95)00075-p. [DOI] [PubMed] [Google Scholar]
  49. van der Poel C. L., Cuypers H. T., Reesink H. W. Hepatitis C virus six years on. Lancet. 1994 Nov 26;344(8935):1475–1479. doi: 10.1016/s0140-6736(94)90293-3. [DOI] [PubMed] [Google Scholar]

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