Abstract
In a review of 106 cases of carcinoma of the thyroid gland, it was noted that a solitary thyroid nodule is the most outstanding single physical sign in this disease. It should be investigated by biopsy of a specimen removed at operation. Patients and physicians were sometimes guilty of delay in this regard.
Papillary carcinoma involved multiple foci within the gland in at least half of the cases and there was a high incidence of regional lymph node metastasis associated with this type.
Doubt was cast on conclusions by other investigators that carcinoma of the thyroid rarely is lethal in patients less than 40 years of age.
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Selected References
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- CRILE G., Jr, HAZARD J. B. Relationship of the age of the patient to the natural history and prognosis of carcinoma of the thyroid. Ann Surg. 1953 Jul;138(1):33–38. doi: 10.1097/00000658-195307000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRAZELL E. L., FOOTE F. W., Jr Papillary thyroid carcinoma: pathological findings in cases with and without clinical evidence of cervical node involvement. Cancer. 1955 Nov-Dec;8(6):1164–1166. doi: 10.1002/1097-0142(1955)8:6<1164::aid-cncr2820080612>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
- MACDONALD I., KOTIN P. Surgical management of papillary carcinoma of the thyroid gland; the case for total thyroidectomy. Ann Surg. 1953 Feb;137(2):156–164. doi: 10.1097/00000658-195302000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDERMOTT W. V., Jr, MORGAN W. S., HAMLIN E., Jr, COPE O. Cancer of the thyroid. J Clin Endocrinol Metab. 1954 Nov;14(11):1336–1354. doi: 10.1210/jcem-14-11-1336. [DOI] [PubMed] [Google Scholar]
- SHALLOW T. A., WAGNER F. B., Jr, COLCHER R. E. Cancer of the thyroid gland; clinical analysis and evaluation of therapy in 144 patients. Surgery. 1956 Feb;39(2):252–259. [PubMed] [Google Scholar]
- SLOAN L. W. Of the origin, characteristics and behavior of thyroid cancer. J Clin Endocrinol Metab. 1954 Nov;14(11):1309–1335. doi: 10.1210/jcem-14-11-1309. [DOI] [PubMed] [Google Scholar]