Abstract
Determination of the amount of lactic acid dehydrogenase in the blood has been demonstrated as a useful aid in the diagnosis of myocardial necrosis. The reliability of the test and the time element of the appearance and disappearance of the enzyme in the blood give it advantages over transminase determinations. In addition there appears to be a correlation of lactic acid dehydrogenase content with metastatic carcinoma. The levels of the substance correlate with the presence or absence of metastatic lesions and also with the extent of the metastasis. Few other clinical states are associated with increased levels of this enzyme, and in most instances the few that are can be excluded by other reliable criteria.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- HILL B. R., LEVI C. Elevation of a serum component in neoplastic disease. Cancer Res. 1954 Aug;14(7):513–515. [PubMed] [Google Scholar]
- MACDONALD R. P., SIMPSON J. R., NOSSAL E. Serum lactic dehydrogenase; a diagnostic aid in myocardial infarction. J Am Med Assoc. 1957 Sep 7;165(1):35–40. doi: 10.1001/jama.1957.02980190037009. [DOI] [PubMed] [Google Scholar]
- ULMER D. D., VALLEE B. L., WACKER W. E. Metalloenzymes and myocardial infarction. II. Malic and lactic dehydrogenase activities and zinc concentrations in serum. N Engl J Med. 1956 Sep 6;255(10):450–456. doi: 10.1056/NEJM195609062551001. [DOI] [PubMed] [Google Scholar]
- WEINSTEIN H. G., ZIMMERMAN H. J. Lactic dehydrogenase activity in human serum. J Lab Clin Med. 1956 Oct;48(4):607–616. [PubMed] [Google Scholar]
- WHITE L. P. Serum enzymes. I. Serum lactic dehydrogenase in myocardial infarction. N Engl J Med. 1956 Nov 22;255(21):984–988. doi: 10.1056/NEJM195611222552103. [DOI] [PubMed] [Google Scholar]
- WROBLEWSKI F., LADUE J. S. Lactic dehydrogenase activity in blood. Proc Soc Exp Biol Med. 1955 Oct;90(1):210–213. doi: 10.3181/00379727-90-21985. [DOI] [PubMed] [Google Scholar]