Abstract
The principle of producing bronchial lavage by deposition of large amounts of heated aerosol has resulted in a significantly greater yield of positive cytologic diagnosis of bronchogenic carcinoma than with repeated “volunteer” specimens of sputum. Positive pressure plus bronchodilators augments greater sputum volume.
Using this technique, cases in which results of bronchoscopy and aspiration biopsy were negative for malignant change, were diagnosed cytologically.
Application of this technique can sometimes detect early lung carcinoma before roentgenographic changes are detectable. Positive tests in clinically far advanced disease may prevent unnecessary surgical intervention.
The simplicity of the technique, the freedom from adverse reactions, and its wide acceptance by the subjects tested, make it valuable in the diagnosis of lung cancer.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARACH A. L., BICKERMAN H. A., BECK G. J., NANDA K. G., PONS E. R., Jr Induced sputum as a diagnostic technique for cancer of the lungs and for mobilization of retained secretions. Arch Intern Med. 1960 Aug;106:230–236. doi: 10.1001/archinte.1960.03820020070010. [DOI] [PubMed] [Google Scholar]
- FARBER S. M., McGRATH A. K., Jr, BENIOFF M. A., ESPEN L. W. The early diagnosis of primary lung cancer by cytologic methods. Dis Chest. 1951 Sep;20(3):237–256. doi: 10.1378/chest.20.3.237. [DOI] [PubMed] [Google Scholar]
- FONTANA R. S., CARR D. T., WOOLNER L. B., MILLER F. K. An evaluation of methods of inducing sputum production in patients with suspected cancer of the lung. Proc Staff Meet Mayo Clin. 1962 Feb 28;37:113–121. [PubMed] [Google Scholar]
- MELAMED M. R., KOSS L. G., CLIFFTON E. E. ROENTGENOLOGICALLY OCCULT LUNG CANCER DIAGNOSED BY CYTOLOGY: REPORT OF 12 CASES. Cancer. 1963 Dec;16:1537–1551. doi: 10.1002/1097-0142(196312)16:12<1537::aid-cncr2820161205>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
- MOTLEY H. L., TOMASHEFSKI J. F. Effect of high and low oxygen levels and intermittent positive pressure breathing on oxygen transport in the lungs in pulmonary fibrosis and emphysema. J Appl Physiol. 1950 Oct;3(4):189–196. doi: 10.1152/jappl.1950.3.4.189. [DOI] [PubMed] [Google Scholar]
- UMIKER W. O., KORST D. R., COLE R. P., MANIKAS S. G. Collection of sputum for cytologic examination: spontaneous vs.artificially produced sputum. N Engl J Med. 1960 Mar 17;262:565–566. doi: 10.1056/NEJM196003172621108. [DOI] [PubMed] [Google Scholar]