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. 1972 Dec;117(6):22–26.

Metronidazole Versus Anaerobes—In Vitro Data and Initial Clinical Observations

Francis P Tally, Vera L Sutter, Sydney M Finegold
PMCID: PMC1518761  PMID: 4635396

Abstract

Metronidazole, a systemic trichomonicide which has been used extensively since 1960, has recently been shown to be active against various anaerobic bacteria in vitro and in experimental infections. In the present study, metronidazole showed significant activity against virtually all of 54 strains of anaerobic and microaerophilic bacteria tested, including Bacteroides fragilis. Since this organism is the anaerobe most commonly isolated from human infections and has demonstrated significant resistance to many antimicrobial agents, metronidazole may prove to be very useful. Our initial clinical evaluation of metronidazole in human anaerobic infections is presented. Because of metronidazole's in vitro activity, its low incidence of toxic reactions, and this initial favorable clinical trial, the drug deserves further evaluation in the management of anaerobic infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COSAR C., JULOU L. Activité de l'(hydroxy-2'éthyl)-1 méthyl-2 nitro-5 imidazole (8.823 R. P.) vis-à-vis des infections expérimentales à Trichomonas vaginalis. Ann Inst Pasteur (Paris) 1959 Feb;96(2):238–241. [PubMed] [Google Scholar]
  2. DAVIES A. H., MCFADZEAN J. A., SQUIRES S. TREATMENT OF VINCENT'S STOMATITIS WITH METRONIDAZOLE. Br Med J. 1964 May 2;1(5391):1149–1150. doi: 10.1136/bmj.1.5391.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Davies A. H. Metronidazole in human infections with syphilis. Br J Vener Dis. 1967 Sep;43(3):197–200. doi: 10.1136/sti.43.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Edwards D. I., Mathison G. E. The mode of action of metronidazole against Trichomonas vaginalis. J Gen Microbiol. 1970 Nov;63(3):297–302. doi: 10.1099/00221287-63-3-297. [DOI] [PubMed] [Google Scholar]
  5. Felner J. M., Dowell V. R., Jr Anaerobic bacterial endocarditis. N Engl J Med. 1970 Nov 26;283(22):1188–1192. doi: 10.1056/NEJM197011262832203. [DOI] [PubMed] [Google Scholar]
  6. Freeman W. A., McFadzean J. A., Whelan J. P. Activity of metronidazole against experimental tetanus and gas gangrene. J Appl Bacteriol. 1968 Dec;31(4):443–447. doi: 10.1111/j.1365-2672.1968.tb00393.x. [DOI] [PubMed] [Google Scholar]
  7. Füzi M., Csukás Z. Das antibakterielle Wirkungsspektrum des Metronidazols. Zentralbl Bakteriol Orig. 1970;213(2):258–262. [PubMed] [Google Scholar]
  8. Füzi M., Csukás Z. Veillonella-törzsek metronidazol-érzékenysége. Fogorv Sz. 1969 Nov;62(11):324–326. [PubMed] [Google Scholar]
  9. GRAY M. S., KANE P. O., SQUIRES S. Further observations on metronidazole (Flagyl). Br J Vener Dis. 1961 Dec;37:278–279. doi: 10.1136/sti.37.4.278. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Ings R. M., Law G. L., Parnell E. W. The metabolism of metronidazole (1-2'-hydroxyethyl-2-methyl-5-nitroimidazole). Biochem Pharmacol. 1966 May;15(5):515–519. doi: 10.1016/0006-2952(66)90017-7. [DOI] [PubMed] [Google Scholar]
  11. KANE P. O., McFADZEAN J. A., SQUIRES S., KING A. J., NICOL C. S. Absorption and excretion of metronidazole. I. Serum concentration and urinary excretion after oral administration. Br J Vener Dis. 1961 Dec;37:273–275. doi: 10.1136/sti.37.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lefebvre Y., Hesseltine H. C. The peripheral white blood cells and metronidazole. JAMA. 1965 Oct 4;194(1):15–18. [PubMed] [Google Scholar]
  13. Lindner R. R., Adeniyi-Jones C. The effect of metronidazole on tropical ulcers. Trans R Soc Trop Med Hyg. 1968;62(5):712–716. doi: 10.1016/0035-9203(68)90123-5. [DOI] [PubMed] [Google Scholar]
  14. Nastro L. J., Finegold S. M. Bactericidal activity of five antimicrobial agents against Bacteroides fragilis. J Infect Dis. 1972 Jul;126(1):104–107. doi: 10.1093/infdis/126.1.104. [DOI] [PubMed] [Google Scholar]
  15. Placidi G. F., Masuoka D. T., Alcaraz A., Taylor J., Earle R. W. Autoradiographic distribution studies on 14C-Metronidazole in mice. Proc West Pharmacol Soc. 1968;11:53–53. [PubMed] [Google Scholar]
  16. Powell S. J., MacLeod I., Wilmot A. J., Elsdon-Dew R. Metronidazole in amoebic dysentery and amoebic liver abscess. Lancet. 1966 Dec 17;2(7477):1329–1331. doi: 10.1016/s0140-6736(66)92081-2. [DOI] [PubMed] [Google Scholar]
  17. Prince H. N., Grunberg E., Titsworth E., DeLorenzo W. F. Effects of l-(2-nitro-l-imidazolyl)-3-methoxy-2-propanol and 2-methyl-5-nitroimidazole-l-ethanol against anaerobic and aerobic bacteria and protozoa. Appl Microbiol. 1969 Nov;18(5):728–730. doi: 10.1128/am.18.5.728-730.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rothstein E., Clancy D. D. Toxicity of disulfiram combined with metronidazole. N Engl J Med. 1969 May 1;280(18):1006–1007. doi: 10.1056/NEJM196905012801807. [DOI] [PubMed] [Google Scholar]
  19. Stambaugh J. E., Feo L. G., Manthei R. W. Isolation and identification of the major urinary metabolite of metronidazole. Life Sci. 1967 Sep 1;6(17):1811–1819. doi: 10.1016/0024-3205(67)90209-3. [DOI] [PubMed] [Google Scholar]
  20. Sutter V. L., Kwok Y. Y., Finegold S. M. Standardized antimicrobial disc susceptibility testing of anaerobic bacteria. I. Susceptibility of Bacteroides fragilis to tetracycline. Appl Microbiol. 1972 Feb;23(2):268–275. doi: 10.1128/am.23.2.268-275.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Taylor J. A., Jr, Migliardi J. R., Von Wittenau M. S. Tinidazole and metronidazole pharmocokinetics in man and mouse. Antimicrob Agents Chemother (Bethesda) 1969;9:267–270. [PubMed] [Google Scholar]
  22. Videau D. Association métronidazole-spiramycin sur les germes anaérobies. Pathol Biol (Paris) 1971 Jun-Jul;19(11):661–666. [PubMed] [Google Scholar]
  23. Wilkinson A. E., Rodin P., McFadzean J. A., Squires S. A note on the effect of metronidazole on the Nichols strain of Treponema pallidum in vitro and in vivo. Br J Vener Dis. 1967 Sep;43(3):201–203. doi: 10.1136/sti.43.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]

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