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. 1995 Sep;103(Suppl 6):197–205. doi: 10.1289/ehp.95103s6197

Chemical contaminants in human milk: an overview.

B R Sonawane 1
PMCID: PMC1518901  PMID: 8549474

Abstract

This review contains a succinct overview of the nature and extent of the problem of contamination of human milk with environmental and occupational chemicals, excluding drugs. Factors influencing the levels of contaminants in breast milk are discussed. Also, data on major chemicals of concern with potential health risk(s) to the general population and risk-benefit considerations are dealt with briefly. Based on the available data on the subject, research needs have been identified and policy recommendations are suggested.

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Selected References

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  1. Amin-Zaki L., Majeed M. A., Greenwood M. R., Elhassani S. B., Clarkson T. W., Doherty R. A. Methylmercury poisoning in the Iraqi suckling infant: a longitudinal study over five years. J Appl Toxicol. 1981 Aug;1(4):210–214. doi: 10.1002/jat.2550010405. [DOI] [PubMed] [Google Scholar]
  2. Ansari G. A., Britt S. G., Reynolds E. S. Isolation and characterization of palmitoylpentachlorophenol from human fat. Bull Environ Contam Toxicol. 1985 May;34(5):661–667. doi: 10.1007/BF01609790. [DOI] [PubMed] [Google Scholar]
  3. Bhattacharyya M. H. Bioavailability of orally administered cadmium and lead to the mother, fetus, and neonate during pregnancy and lactation: an overview. Sci Total Environ. 1983 Jun;28:327–342. doi: 10.1016/s0048-9697(83)80030-8. [DOI] [PubMed] [Google Scholar]
  4. Brilliant L. B., Wilcox K., Van Amburg G., Eyster J., Isbister J., Bloomer A. W., Humphrey H., Price H. Breast-milk monitoring to measure Michigan's contamination with polybrominated biphenyls. Lancet. 1978 Sep 23;2(8091):643–646. doi: 10.1016/s0140-6736(78)92758-7. [DOI] [PubMed] [Google Scholar]
  5. Bush B., Snow J., Conner S., Rueckert L., Han Y., Dymerski P., Hilker D. Mirex in human milk in upstate New York. Arch Environ Contam Toxicol. 1983 Nov;12(6):739–746. doi: 10.1007/BF01060759. [DOI] [PubMed] [Google Scholar]
  6. Butte N. F., Wong W. W., Patterson B. W., Garza C., Klein P. D. Human-milk intake measured by administration of deuterium oxide to the mother: a comparison with the test-weighing technique. Am J Clin Nutr. 1988 May;47(5):815–821. doi: 10.1093/ajcn/47.5.815. [DOI] [PubMed] [Google Scholar]
  7. Cordle F., Corneliussen P., Jelinek C., Hackley B., Lehman R., McLaughlin J., Rhoden R., Shapiro R. Human exposure to polychorinated biphenyls and polybrominated biphenyls. Environ Health Perspect. 1978 Jun;24:157–172. doi: 10.1289/ehp.7824157. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cripps D. J., Peters H. A., Gocmen A., Dogramici I. Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br J Dermatol. 1984 Oct;111(4):413–422. doi: 10.1111/j.1365-2133.1984.tb06603.x. [DOI] [PubMed] [Google Scholar]
  9. Curley A., Burse V. W., Jennings R. W., Villanueva E. C., Tomatis L., Akazaki K. Chlorinated hydrocarbon pesticides and related compounds in adipose tissue from people of Japan. Nature. 1973 Mar 30;242(5396):338–340. doi: 10.1038/242338a0. [DOI] [PubMed] [Google Scholar]
  10. Currie R. A., Kadis V. W., Breitkreitz W. E., Cunningham G. B., Bruns G. W. Pesticide residues in human milk, Alberta, Canada--1966-70, 1977-78. Pestic Monit J. 1979 Sep;13(2):52–55. [PubMed] [Google Scholar]
  11. Dillon J. C., Martin G. B., O'Brien H. T. Pesticide residues in human milk. Food Cosmet Toxicol. 1981 Aug;19(4):437–442. doi: 10.1016/0015-6264(81)90447-8. [DOI] [PubMed] [Google Scholar]
  12. Freudenthal J., Greve P. A. Polychlorinated terphenyls in the environment. Bull Environ Contam Toxicol. 1973 Aug;10(2):108–111. doi: 10.1007/BF01685881. [DOI] [PubMed] [Google Scholar]
  13. Fries G. F. The PBB episode in Michigan: an overall appraisal. Crit Rev Toxicol. 1985;16(2):105–156. doi: 10.3109/10408448509056268. [DOI] [PubMed] [Google Scholar]
  14. Fujita M., Takabatake E. Mercury levels in human maternal and neonatal blood, hair and milk. Bull Environ Contam Toxicol. 1977 Aug;18(2):205–209. doi: 10.1007/BF01686068. [DOI] [PubMed] [Google Scholar]
  15. Funatsu I., Yamashita F., Ito Y., Tsugawa S., Funatsu T. Polychlorbiphenyls (PCB) induced fetopathy. I. Clinical observation. Kurume Med J. 1972;19(1):43–51. doi: 10.2739/kurumemedj.19.43. [DOI] [PubMed] [Google Scholar]
  16. Heath R. G., Harless R. L., Gross M. L., Lyon P. A., Dupuy A. E., Jr, McDaniel D. D. Determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human milk at the 0.1-10 parts-per-trillion level: method validation and survey results. Anal Chem. 1986 Feb;58(2):463–468. doi: 10.1021/ac00293a044. [DOI] [PubMed] [Google Scholar]
  17. Hsu S. T., Ma C. I., Hsu S. K., Wu S. S., Hsu N. H., Yeh C. C., Wu S. B. Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup. Environ Health Perspect. 1985 Feb;59:5–10. doi: 10.1289/ehp.59-1568088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Jensen A. A. Polychlorobiphenyls (PCBs), polychlorodibenzo-p-dioxins (PCDDs) and polychlorodibenzofurans (PCDFs) in human milk, blood and adipose tissue. Sci Total Environ. 1987 Jul;64(3):259–293. doi: 10.1016/0048-9697(87)90250-6. [DOI] [PubMed] [Google Scholar]
  19. Jonsson V., Liu G. J., Armbruster J., Kettelhut L. L., Drucker B. Chlorohydrocarbon pesticide residues in human milk in Greater St. Louis, Missouri 1977. Am J Clin Nutr. 1977 Jul;30(7):1106–1109. doi: 10.1093/ajcn/30.7.1106. [DOI] [PubMed] [Google Scholar]
  20. Kontek M., Kubacki S., Paradowski S., Wierzchowiecka B. Badanie zawartości pestycydów chloroorganicznych w mleku kobiecym. Pediatr Pol. 1971 Feb;46(2):183–188. [PubMed] [Google Scholar]
  21. Kroger M. Insecticide residues in human milk. J Pediatr. 1972 Mar;80(3):401–405. doi: 10.1016/s0022-3476(72)80496-7. [DOI] [PubMed] [Google Scholar]
  22. Lakritz L., Pensabene J. W. Survey of human milk for volatile N-nitrosamines and the influence of diet on their formation. Food Chem Toxicol. 1984 Sep;22(9):721–724. doi: 10.1016/0278-6915(84)90199-6. [DOI] [PubMed] [Google Scholar]
  23. Lamm S. H., Rosen J. F. Lead contamination in milks fed to infants: 1972-1973. Pediatrics. 1974 Feb;53(2):137–141. [PubMed] [Google Scholar]
  24. Landrigan P. J., Wilcox K. R., Jr, Silva J., Jr, Humphrey H. E., Kauffman C., Heath C. W., Jr Cohort study of Michigan residents exposed to polybrominated biphenyls: epidemiologic and immunologic findings. Ann N Y Acad Sci. 1979 May 31;320:284–294. doi: 10.1111/j.1749-6632.1979.tb56611.x. [DOI] [PubMed] [Google Scholar]
  25. Larsson B., Slorach S. A., Hagman U., Hofvander Y. WHO collaborative breast feeding study. II. Levels of lead and cadmium in Swedish human milk, 1978-1979. Acta Paediatr Scand. 1981;70(3):281–284. doi: 10.1111/j.1651-2227.1981.tb16552.x. [DOI] [PubMed] [Google Scholar]
  26. Lönnerdal B., Asquith M. T. Malathion not detected in breast milk of women living in aerial spraying areas. N Engl J Med. 1982 Aug 12;307(7):439–439. doi: 10.1056/NEJM198208123070713. [DOI] [PubMed] [Google Scholar]
  27. Mattison D. R., Wohlleb J., To T., Lamb Y., Faitak S., Brewster M. A., Walls R. C., Selevan S. G. Pesticide concentrations in Arkansas breast milk. J Ark Med Soc. 1992 Apr;88(11):553–557. [PubMed] [Google Scholar]
  28. Mes J., Davies D. J. Presence of polychlorinated biphenyl and organochlorine pesticide residues and the absence of polychlorinated terphenyls in Canadian human milk samples. Bull Environ Contam Toxicol. 1979 Feb;21(3):381–387. doi: 10.1007/BF01685440. [DOI] [PubMed] [Google Scholar]
  29. Miller F. D., Brilliant L. B., Copeland R. Polybrominated biphenyls in lactating Michigan women: persistence in the population. Bull Environ Contam Toxicol. 1984 Feb;32(2):125–133. doi: 10.1007/BF01607475. [DOI] [PubMed] [Google Scholar]
  30. Minagawa K., Takizawa Y., Sakai H., Sasagawa I. [Polychlorinated terphenyls in a human fat and mother's milk (author's transl)]. Nihon Eiseigaku Zasshi. 1974 Feb;28(6):543–547. doi: 10.1265/jjh.28.543. [DOI] [PubMed] [Google Scholar]
  31. Miyazaki T. Residues of the synergist S-421 in human milk collected from the Tokyo metropolitan area. Bull Environ Contam Toxicol. 1982 Nov;29(5):566–569. doi: 10.1007/BF01669622. [DOI] [PubMed] [Google Scholar]
  32. Mussalo-Rauhamaa H., Pyysalo H., Moilanen R. Influence of diet and other factors on the levels of organochlorine compounds in human adipose tissue in Finland. J Toxicol Environ Health. 1984;13(4-6):689–704. doi: 10.1080/15287398409530532. [DOI] [PubMed] [Google Scholar]
  33. Peters H. A., Gocmen A., Cripps D. J., Bryan G. T., Dogramaci I. Epidemiology of hexachlorobenzene-induced porphyria in Turkey: clinical and laboratory follow-up after 25 years. Arch Neurol. 1982 Dec;39(12):744–749. doi: 10.1001/archneur.1982.00510240006002. [DOI] [PubMed] [Google Scholar]
  34. Rogan W. J., Blanton P. J., Portier C. J., Stallard E. Should the presence of carcinogens in breast milk discourage breast feeding? Regul Toxicol Pharmacol. 1991 Jun;13(3):228–240. doi: 10.1016/0273-2300(91)90065-4. [DOI] [PubMed] [Google Scholar]
  35. Rogan W. J., Gladen B. C., Hung K. L., Koong S. L., Shih L. Y., Taylor J. S., Wu Y. C., Yang D., Ragan N. B., Hsu C. C. Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science. 1988 Jul 15;241(4863):334–336. doi: 10.1126/science.3133768. [DOI] [PubMed] [Google Scholar]
  36. Rogan W. J., Gladen B. C., McKinney J. D., Carreras N., Hardy P., Thullen J., Tingelstad J., Tully M. Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. Am J Public Health. 1986 Feb;76(2):172–177. doi: 10.2105/ajph.76.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Savage E. P., Keefe T. J., Tessari J. D., Wheeler H. W., Applehans F. M., Goes E. A., Ford S. A. National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. Am J Epidemiol. 1981 Apr;113(4):413–422. doi: 10.1093/oxfordjournals.aje.a113109. [DOI] [PubMed] [Google Scholar]
  38. Schwartz D. A., Newsum L. A., Heifetz R. M. Parental occupation and birth outcome in an agricultural community. Scand J Work Environ Health. 1986 Feb;12(1):51–54. doi: 10.5271/sjweh.2180. [DOI] [PubMed] [Google Scholar]
  39. Seagull E. A. Developmental abilities of children exposed to polybrominated biphenyls (PBB). Am J Public Health. 1983 Mar;73(3):281–285. doi: 10.2105/ajph.73.3.281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Skaare J. U., Tuveng J. M., Sande H. A. Organochlorine pesticides and polychlorinated biphenyls in maternal adipose tissue, blood, milk, and cord blood from mothers and their infants living in Norway. Arch Environ Contam Toxicol. 1988 Jan;17(1):55–63. doi: 10.1007/BF01055154. [DOI] [PubMed] [Google Scholar]
  41. Skerfving S. Mercury in women exposed to methylmercury through fish consumption, and in their newborn babies and breast milk. Bull Environ Contam Toxicol. 1988 Oct;41(4):475–482. doi: 10.1007/BF02020989. [DOI] [PubMed] [Google Scholar]
  42. Stacey C. I., Perriman W. S., Whitney S. Organochlorine pesticide residue levels in human milk: Western Australia, 1979-1980. Arch Environ Health. 1985 Mar-Apr;40(2):102–108. doi: 10.1080/00039896.1985.10545898. [DOI] [PubMed] [Google Scholar]
  43. Stacey C. I., Tatum T. House treatment with organochlorine pesticides and their levels in human milk--Perth, Western Australia. Bull Environ Contam Toxicol. 1985 Aug;35(2):202–208. doi: 10.1007/BF01636499. [DOI] [PubMed] [Google Scholar]
  44. Takahashi W., Parks L. H. Organochlorine pesticide residues in human tissues, Hawaii, 1968-1980. Hawaii Med J. 1982 Sep;41(9):250–251. [PubMed] [Google Scholar]
  45. Takahashi W., Saidin D., Takei G., Wong L. Organochloride pesticide residues in human milk in Hawaii, 1979-80. Bull Environ Contam Toxicol. 1981 Oct;27(4):506–511. doi: 10.1007/BF01611056. [DOI] [PubMed] [Google Scholar]
  46. Trundle J. I., Skellern G. G. Gas chromatographic determination of nicotine in human breast milk. J Clin Hosp Pharm. 1983 Sep;8(3):289–293. doi: 10.1111/j.1365-2710.1983.tb01108.x. [DOI] [PubMed] [Google Scholar]
  47. Weil W. B., Spencer M., Benjamin D., Seagull E. The effect of polybrominated biphenyl on infants and young children. J Pediatr. 1981 Jan;98(1):47–51. doi: 10.1016/s0022-3476(81)80531-8. [DOI] [PubMed] [Google Scholar]
  48. Yeh C. Y., Kuo P. H., Tsai S. T., Wang G. Y., Wang Y. T. A study on pesticide residues in umbilical cord blood and maternal milk. Taiwan Yi Xue Hui Za Zhi. 1976 Aug;75(8):463–470. [PubMed] [Google Scholar]

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