Abstract
The carcinogenic effects of exposure to ionizing radiation vary markedly with age, as revealed by studies of Japanese atomic bomb survivors and of Marshall Islanders exposed to fallout from U.S. nuclear weapons tests in the South Pacific in 1954. An increase in cancers of adulthood after intrauterine exposure, as reported in 1988, has not been sustained. After childhood exposure, increases in leukemia, breast cancer, and thyroid cancer are well established. The carcinogenic effects of radiation on the young have been reported after intrauterine exposures and after exposures during childhood. Cancers with short latent periods such as leukemia occur during childhood, but those with long latent periods such as breast cancer occur in adulthood.
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Selected References
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- Bithell J. F., Stewart A. M. Pre-natal irradiation and childhood malignancy: a review of British data from the Oxford Survey. Br J Cancer. 1975 Mar;31(3):271–287. doi: 10.1038/bjc.1975.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GILES D., HEWITT D., STEWART A., WEBB J. Malignant disease in childhood and diagnostic irradiation in utero. Lancet. 1956 Sep 1;271(6940):447–447. doi: 10.1016/s0140-6736(56)91923-7. [DOI] [PubMed] [Google Scholar]
- Larsen P. R., Conard R. A., Knudsen K. D., Robbins J., Wolff J., Rall J. E., Nicoloff J. T., Dobyns B. M. Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA. 1982 Mar 19;247(11):1571–1575. [PubMed] [Google Scholar]
- MACMAHON B. Prenatal x-ray exposure and childhood cancer. J Natl Cancer Inst. 1962 May;28:1173–1191. [PubMed] [Google Scholar]
- MacMahon B. Prenatal x-ray exposure and twins. N Engl J Med. 1985 Feb 28;312(9):576–577. doi: 10.1056/NEJM198502283120909. [DOI] [PubMed] [Google Scholar]
- Tokunaga M., Land C. E., Tokuoka S., Nishimori I., Soda M., Akiba S. Incidence of female breast cancer among atomic bomb survivors, 1950-1985. Radiat Res. 1994 May;138(2):209–223. [PubMed] [Google Scholar]
- Yoshimoto Y., Kato H., Schull W. J. Risk of cancer among children exposed in utero to A-bomb radiations, 1950-84. Lancet. 1988 Sep 17;2(8612):665–669. doi: 10.1016/s0140-6736(88)90477-1. [DOI] [PubMed] [Google Scholar]