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. 1995 Nov;103(Suppl 8):283–286. doi: 10.1289/ehp.95103s8283

Racial, ethnic, and gender variations in cancer risk: considerations for future epidemiologic research.

S H Zahm 1, J F Fraumeni Jr 1
PMCID: PMC1518973  PMID: 8741799

Abstract

There is no question that the risk of many cancers varies substantially by race, ethnic group, and gender. Although important clues to cancer etiology may come from investigating the differences in risk across subgroups of the population, epidemiologic research has often focused on white men. More descriptive and analytic studies are needed to identify and explain variations in risk among population subgroups. Especially important are studies to clarify the role of differential exposures, susceptibility, and diagnostic factors in cancer incidence, although differences in treatment may contribute to variations in cancer mortality. Improvements in classification of ethnicity, assessment of carcinogenic exposures in various subpopulations, and measures of host susceptibility states should augment future epidemiologic research designed to better understand mechanisms underlying the racial, ethnic, and gender differences in cancer risk.

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Selected References

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  1. Baquet C. R., Horm J. W., Gibbs T., Greenwald P. Socioeconomic factors and cancer incidence among blacks and whites. J Natl Cancer Inst. 1991 Apr 17;83(8):551–557. doi: 10.1093/jnci/83.8.551. [DOI] [PubMed] [Google Scholar]
  2. Bergner L. Race, health, and health services. Am J Public Health. 1993 Jul;83(7):939–941. doi: 10.2105/ajph.83.7.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blum M., Demierre A., Grant D. M., Heim M., Meyer U. A. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5237–5241. doi: 10.1073/pnas.88.12.5237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown L. M., Hoover R. N., Greenberg R. S., Schoenberg J. B., Schwartz A. G., Swanson G. M., Liff J. M., Silverman D. T., Hayes R. B., Pottern L. M. Are racial differences in squamous cell esophageal cancer explained by alcohol and tobacco use? J Natl Cancer Inst. 1994 Sep 7;86(17):1340–1345. doi: 10.1093/jnci/86.17.1340. [DOI] [PubMed] [Google Scholar]
  5. Butler M. A., Lang N. P., Young J. F., Caporaso N. E., Vineis P., Hayes R. B., Teitel C. H., Massengill J. P., Lawsen M. F., Kadlubar F. F. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics. 1992 Jun;2(3):116–127. doi: 10.1097/00008571-199206000-00003. [DOI] [PubMed] [Google Scholar]
  6. Caplan L. S., Wells B. L., Haynes S. Breast cancer screening among older racial/ethnic minorities and whites: barriers to early detection. J Gerontol. 1992 Nov;47(Spec No):101–110. [PubMed] [Google Scholar]
  7. Day G. L., Blot W. J., Austin D. F., Bernstein L., Greenberg R. S., Preston-Martin S., Schoenberg J. B., Winn D. M., McLaughlin J. K., Fraumeni J. F., Jr Racial differences in risk of oral and pharyngeal cancer: alcohol, tobacco, and other determinants. J Natl Cancer Inst. 1993 Mar 17;85(6):465–473. doi: 10.1093/jnci/85.6.465. [DOI] [PubMed] [Google Scholar]
  8. Devesa S. S., Diamond E. L. Association of breast cancer and cervical cancer incidence with income and education among whites and blacks. J Natl Cancer Inst. 1980 Sep;65(3):515–528. [PubMed] [Google Scholar]
  9. Devesa S. S., Diamond E. L. Socioeconomic and racial differences in lung cancer incidence. Am J Epidemiol. 1983 Dec;118(6):818–831. doi: 10.1093/oxfordjournals.aje.a113700. [DOI] [PubMed] [Google Scholar]
  10. Eley J. W., Hill H. A., Chen V. W., Austin D. F., Wesley M. N., Muss H. B., Greenberg R. S., Coates R. J., Correa P., Redmond C. K. Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study. JAMA. 1994 Sep 28;272(12):947–954. doi: 10.1001/jama.272.12.947. [DOI] [PubMed] [Google Scholar]
  11. Escarce J. J., Epstein K. R., Colby D. C., Schwartz J. S. Racial differences in the elderly's use of medical procedures and diagnostic tests. Am J Public Health. 1993 Jul;83(7):948–954. doi: 10.2105/ajph.83.7.948. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Freeman H. P. The impact of clinical trial protocols on patient care systems in a large city hospital. Access for the socially disadvantaged. Cancer. 1993 Nov 1;72(9 Suppl):2834–2838. doi: 10.1002/1097-0142(19931101)72:9+<2834::aid-cncr2820721512>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  13. Freeman H. Race, poverty, and cancer. J Natl Cancer Inst. 1991 Apr 17;83(8):526–527. doi: 10.1093/jnci/83.8.526. [DOI] [PubMed] [Google Scholar]
  14. Frost F., Taylor V., Fries E. Racial misclassification of Native Americans in a surveillance, epidemiology, and end results cancer registry. J Natl Cancer Inst. 1992 Jun 17;84(12):957–962. doi: 10.1093/jnci/84.12.957. [DOI] [PubMed] [Google Scholar]
  15. Hankin J. H., Zhao L. P., Wilkens L. R., Kolonel L. N. Attributable risk of breast, prostate, and lung cancer in Hawaii due to saturated fat. Cancer Causes Control. 1992 Jan;3(1):17–23. doi: 10.1007/BF00051907. [DOI] [PubMed] [Google Scholar]
  16. Hayes R. B. Biomarkers in occupational cancer epidemiology: considerations in study design. Environ Health Perspect. 1992 Nov;98:149–154. doi: 10.1289/ehp.9298149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hirvonen A., Husgafvel-Pursiainen K., Karjalainen A., Anttila S., Vainio H. Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population. Cancer Epidemiol Biomarkers Prev. 1992 Sep-Oct;1(6):485–489. [PubMed] [Google Scholar]
  18. Howard J., Hankey B. F., Greenberg R. S., Austin D. F., Correa P., Chen V. W., Durako S. A collaborative study of differences in the survival rates of black patients and white patients with cancer. Cancer. 1992 May 1;69(9):2349–2360. doi: 10.1002/1097-0142(19920501)69:9<2349::aid-cncr2820690925>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  19. Hunter C. P., Redmond C. K., Chen V. W., Austin D. F., Greenberg R. S., Correa P., Muss H. B., Forman M. R., Wesley M. N., Blacklow R. S. Breast cancer: factors associated with stage at diagnosis in black and white women. Black/White Cancer Survival Study Group. J Natl Cancer Inst. 1993 Jul 21;85(14):1129–1137. doi: 10.1093/jnci/85.14.1129. [DOI] [PubMed] [Google Scholar]
  20. Kelsey J. L., Gammon M. D. Epidemiology of breast cancer. Epidemiol Rev. 1990;12:228–240. doi: 10.1093/oxfordjournals.epirev.a036056. [DOI] [PubMed] [Google Scholar]
  21. Kolonel L. N., Goodman M. T. Racial variation in cancer incidence: fact or artifact? J Natl Cancer Inst. 1992 Jun 17;84(12):915–916. doi: 10.1093/jnci/84.12.915. [DOI] [PubMed] [Google Scholar]
  22. Le Marchand L., Wilkens L. R., Kolonel L. N. Ethnic differences in the lung cancer risk associated with smoking. Cancer Epidemiol Biomarkers Prev. 1992 Jan-Feb;1(2):103–107. [PubMed] [Google Scholar]
  23. Lloyd J. W. Long-term mortality study of steelworkers. V. Respiratory cancer in coke plant workers. J Occup Med. 1971 Feb;13(2):53–68. [PubMed] [Google Scholar]
  24. Mallin K., Anderson K. Cancer mortality in Illinois Mexican and Puerto Rican immigrants, 1979-1984. Int J Cancer. 1988 May 15;41(5):670–676. doi: 10.1002/ijc.2910410506. [DOI] [PubMed] [Google Scholar]
  25. McWhorter W. P., Schatzkin A. G., Horm J. W., Brown C. C. Contribution of socioeconomic status to black/white differences in cancer incidence. Cancer. 1989 Mar 1;63(5):982–987. doi: 10.1002/1097-0142(19890301)63:5<982::aid-cncr2820630533>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  26. Nakachi K., Imai K., Hayashi S., Watanabe J., Kawajiri K. Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res. 1991 Oct 1;51(19):5177–5180. [PubMed] [Google Scholar]
  27. Nakajima M., Yokoi T., Mizutani M., Shin S., Kadlubar F. F., Kamataki T. Phenotyping of CYP1A2 in Japanese population by analysis of caffeine urinary metabolites: absence of mutation prescribing the phenotype in the CYP1A2 gene. Cancer Epidemiol Biomarkers Prev. 1994 Jul-Aug;3(5):413–421. [PubMed] [Google Scholar]
  28. Osann K. E., Anton-Culver H., Kurosaki T., Taylor T. Sex differences in lung-cancer risk associated with cigarette smoking. Int J Cancer. 1993 Apr 22;54(1):44–48. doi: 10.1002/ijc.2910540108. [DOI] [PubMed] [Google Scholar]
  29. Polednak A. P. A comparison of survival of black and white female breast cancer cases in Upstate New York. Cancer Detect Prev. 1988;11(3-6):245–249. [PubMed] [Google Scholar]
  30. Polednak A. P. Cancer incidence in the Puerto Rican-born population of Connecticut. Cancer. 1992 Sep 1;70(5):1172–1176. doi: 10.1002/1097-0142(19920901)70:5<1172::aid-cncr2820700524>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  31. Polednak A. P. Cancer incidence in the Puerto Rican-born population of Long Island, New York. Am J Public Health. 1991 Nov;81(11):1405–1407. doi: 10.2105/ajph.81.11.1405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Reynolds T. California registries expand SEER's minority coverage. J Natl Cancer Inst. 1993 Jan 6;85(1):11–12. doi: 10.1093/jnci/85.1.11. [DOI] [PubMed] [Google Scholar]
  33. Risch H. A., Howe G. R., Jain M., Burch J. D., Holowaty E. J., Miller A. B. Are female smokers at higher risk for lung cancer than male smokers? A case-control analysis by histologic type. Am J Epidemiol. 1993 Sep 1;138(5):281–293. doi: 10.1093/oxfordjournals.aje.a116857. [DOI] [PubMed] [Google Scholar]
  34. Rosenwaike I. Mortality differentials among persons born in Cuba, Mexico, and Puerto Rico residing in the United States, 1979-81. Am J Public Health. 1987 May;77(5):603–606. doi: 10.2105/ajph.77.5.603. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Shields P. G., Caporaso N. E., Falk R. T., Sugimura H., Trivers G. E., Trump B. F., Hoover R. N., Weston A., Harris C. C. Lung cancer, race, and a CYP1A1 genetic polymorphism. Cancer Epidemiol Biomarkers Prev. 1993 Sep-Oct;2(5):481–485. [PubMed] [Google Scholar]
  36. Tefre T., Ryberg D., Haugen A., Nebert D. W., Skaug V., Brøgger A., Børresen A. L. Human CYP1A1 (cytochrome P(1)450) gene: lack of association between the Msp I restriction fragment length polymorphism and incidence of lung cancer in a Norwegian population. Pharmacogenetics. 1991 Oct;1(1):20–25. doi: 10.1097/00008571-199110000-00004. [DOI] [PubMed] [Google Scholar]
  37. Trapido E. J., Chen F., Davis K., Lewis N., MacKinnon J. A. Cancer among Hispanic males in south Florida. Nine years of incidence data. Arch Intern Med. 1994 Jan 24;154(2):177–185. [PubMed] [Google Scholar]
  38. Trapido E. J., Chen F., Davis K., Lewis N., MacKinnon J. A., Strait P. M. Cancer in south Florida Hispanic women. A 9-year assessment. Arch Intern Med. 1994 May 23;154(10):1083–1088. [PubMed] [Google Scholar]
  39. Wells B. L., Horm J. W. Stage at diagnosis in breast cancer: race and socioeconomic factors. Am J Public Health. 1992 Oct;82(10):1383–1385. doi: 10.2105/ajph.82.10.1383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Winn D. M., Blot W. J., Shy C. M., Pickle L. W., Toledo A., Fraumeni J. F., Jr Snuff dipping and oral cancer among women in the southern United States. N Engl J Med. 1981 Mar 26;304(13):745–749. doi: 10.1056/NEJM198103263041301. [DOI] [PubMed] [Google Scholar]
  41. Zahm S. H., Pottern L. M., Lewis D. R., Ward M. H., White D. W. Inclusion of women and minorities in occupational cancer epidemiologic research. J Occup Med. 1994 Aug;36(8):842–847. [PubMed] [Google Scholar]
  42. Ziegler R. G., Hoover R. N., Pike M. C., Hildesheim A., Nomura A. M., West D. W., Wu-Williams A. H., Kolonel L. N., Horn-Ross P. L., Rosenthal J. F. Migration patterns and breast cancer risk in Asian-American women. J Natl Cancer Inst. 1993 Nov 17;85(22):1819–1827. doi: 10.1093/jnci/85.22.1819. [DOI] [PubMed] [Google Scholar]

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