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. 1995 Oct;103(10):952–957. doi: 10.1289/ehp.95103952

A longitudinal study of chronic lead exposure and physical growth in Boston children.

R Kim 1, H Hu 1, A Rotnitzky 1, D Bellinger 1, H Needleman 1
PMCID: PMC1519152  PMID: 8529592

Abstract

We investigated the cross-sectional and longitudinal relationships between chronic exposure to lead and physical growth among a cohort of children reassessed 13 years after initial examination. We measured weight, height, and dentin lead levels of 270 children in 1975-78. In 1989-1990 we reexamined 79 of these children for measurement of weight, height, and bone lead levels by means of in vivo K X-ray fluorescence. To avoid potential confounding by race and chelation history, analysis was restricted to white subjects without a history of lead chelation therapy. A total of 236 subjects provided complete information for the study of cross-sectional relationship between dentin lead levels and changes in physical growth: 58 subjects for the study of longitudinal relationship between dentin lead levels and changes in physical growth and 54 subjects for the study of longitudinal relationship between bone lead levels and changes in physical growth. Dentin lead levels averaged 14.9 micrograms/g; tibia and patella lead levels averaged 1.2 and 5.0 micrograms/g, respectively. With control for potential confounders including age, sex, baseline body size, and mother's socioeconomic status, log10 dentin lead level was positively associated with body mass index as of 1975-1978 (beta = 1.02, p = 0.03) and increase in body mass index between 1975-78 and 1989-90 (beta = 2.65, p = 0.03). Bone lead levels were not significantly associated with physical growth. This is the first study relating chronic lead exposure to body mass index. The results suggest that chronic lead exposure in childhood may result in obesity that persists into adulthood.

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Selected References

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  1. Angle C. R., Kuntzelman D. R. Increased erythrocyte protoporphyrins and blood lead--a pilot study of childhood growth patterns. J Toxicol Environ Health. 1989;26(2):149–156. doi: 10.1080/15287398909531241. [DOI] [PubMed] [Google Scholar]
  2. Barry P. S., Mossman D. B. Lead concentrations in human tissues. Br J Ind Med. 1970 Oct;27(4):339–351. doi: 10.1136/oem.27.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Burger D. E., Milder F. L., Morsillo P. R., Adams B. B., Hu H. Automated bone lead analysis by K-x-ray fluorescence for the clinical environment. Basic Life Sci. 1990;55:287–292. doi: 10.1007/978-1-4613-1473-8_39. [DOI] [PubMed] [Google Scholar]
  4. CLARK P. J. The heritability of certain anthropometric characters as ascertained from measurements of twins. Am J Hum Genet. 1956 Mar;8(1):49–54. [PMC free article] [PubMed] [Google Scholar]
  5. Camoratto A. M., White L. M., Lau Y. S., Ware G. O., Berry W. D., Moriarty C. M. Effect of exposure to low level lead on growth and growth hormone release in rats. Toxicology. 1993 Oct 25;83(1-3):101–114. doi: 10.1016/0300-483x(93)90095-a. [DOI] [PubMed] [Google Scholar]
  6. Carroll K. G., Needleman H., Tuncay O. C., Shapiro I. M. The distribution of lead in human deciduous teeth. Experientia. 1972 Apr 15;28(4):434–435. doi: 10.1007/BF02008325. [DOI] [PubMed] [Google Scholar]
  7. Chettle D. R., Scott M. C., Somervaille L. J. Lead in bone: sampling and quantitation using K X-rays excited by 109Cd. Environ Health Perspect. 1991 Feb;91:49–55. doi: 10.1289/ehp.919149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Duggan M. J. The uptake and excretion of lead by young children. Arch Environ Health. 1983 Jul-Aug;38(4):246–247. doi: 10.1080/00039896.1983.10545810. [DOI] [PubMed] [Google Scholar]
  9. Gordon C. L., Chettle D. R., Webber C. E. An improved instrument for the in vivo detection of lead in bone. Br J Ind Med. 1993 Jul;50(7):637–641. doi: 10.1136/oem.50.7.637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Grandjean P., Hansen O. N., Lyngbye K. Analysis of lead in circumpulpal dentin of deciduous teeth. Ann Clin Lab Sci. 1984 Jul-Aug;14(4):270–275. [PubMed] [Google Scholar]
  11. Greene T., Ernhart C. B. Prenatal and preschool age lead exposure: relationship with size. Neurotoxicol Teratol. 1991 Jul-Aug;13(4):417–427. doi: 10.1016/0892-0362(91)90091-a. [DOI] [PubMed] [Google Scholar]
  12. Harlan W. R. The relationship of blood lead levels to blood pressure in the U.S. population. Environ Health Perspect. 1988 Jun;78:9–13. doi: 10.1289/ehp.88789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hu H., Aro A., Rotnitzky A. Bone lead measured by X-ray fluorescence: epidemiologic methods. Environ Health Perspect. 1995 Feb;103 (Suppl 1):105–110. doi: 10.1289/ehp.95103s1105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hu H., Milder F. L., Burger D. E. X-ray fluorescence measurements of lead burden in subjects with low-level community lead exposure. Arch Environ Health. 1990 Nov-Dec;45(6):335–341. doi: 10.1080/00039896.1990.10118752. [DOI] [PubMed] [Google Scholar]
  15. Hu H., Milder F. L., Burger D. E. X-ray fluorescence: issues surrounding the application of a new tool for measuring burden of lead. Environ Res. 1989 Aug;49(2):295–317. doi: 10.1016/s0013-9351(89)80074-x. [DOI] [PubMed] [Google Scholar]
  16. Huseman C. A., Moriarty C. M., Angle C. R. Childhood lead toxicity and impaired release of thyrotropin-stimulating hormone. Environ Res. 1987 Apr;42(2):524–533. doi: 10.1016/s0013-9351(87)80219-0. [DOI] [PubMed] [Google Scholar]
  17. Huseman C. A., Varma M. M., Angle C. R. Neuroendocrine effects of toxic and low blood lead levels in children. Pediatrics. 1992 Aug;90(2 Pt 1):186–189. [PubMed] [Google Scholar]
  18. Johnson N. E., Tenuta K. Diets and lead blood levels of children who practice pica. Environ Res. 1979 Apr;18(2):369–376. doi: 10.1016/0013-9351(79)90113-0. [DOI] [PubMed] [Google Scholar]
  19. Landrigan P. J., Todd A. C. Direct measurement of lead in bone. A promising biomarker. JAMA. 1994 Jan 19;271(3):239–240. [PubMed] [Google Scholar]
  20. Mann G. V. The influence of obesity on health (second of two parts). N Engl J Med. 1974 Aug 1;291(5):226–232. doi: 10.1056/NEJM197408012910504. [DOI] [PubMed] [Google Scholar]
  21. Manson J. E., Colditz G. A., Stampfer M. J., Willett W. C., Rosner B., Monson R. R., Speizer F. E., Hennekens C. H. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990 Mar 29;322(13):882–889. doi: 10.1056/NEJM199003293221303. [DOI] [PubMed] [Google Scholar]
  22. Needleman H. L., Davidson I., Sewell E. M., Shapiro I. M. Subclinical lead exposure in philadelphia schoolchildren. Identification by dentine lead analysis. N Engl J Med. 1974 Jan 31;290(5):245–248. doi: 10.1056/NEJM197401312900504. [DOI] [PubMed] [Google Scholar]
  23. Needleman H. L., Gatsonis C. A. Low-level lead exposure and the IQ of children. A meta-analysis of modern studies. JAMA. 1990 Feb 2;263(5):673–678. [PubMed] [Google Scholar]
  24. Needleman H. L., Gunnoe C., Leviton A., Reed R., Peresie H., Maher C., Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. doi: 10.1056/NEJM197903293001301. [DOI] [PubMed] [Google Scholar]
  25. Pirkle J. L., Schwartz J., Landis J. R., Harlan W. R. The relationship between blood lead levels and blood pressure and its cardiovascular risk implications. Am J Epidemiol. 1985 Feb;121(2):246–258. doi: 10.1093/oxfordjournals.aje.a113995. [DOI] [PubMed] [Google Scholar]
  26. Pocock S. J., Shaper A. G., Ashby D., Delves H. T., Clayton B. E. The relationship between blood lead, blood pressure, stroke, and heart attacks in middle-aged British men. Environ Health Perspect. 1988 Jun;78:23–30. doi: 10.1289/ehp.887823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rabinowitz M. B., Leviton A., Bellinger D. Relationships between serial blood lead levels and exfoliated tooth dentin lead levels: models of tooth lead kinetics. Calcif Tissue Int. 1993 Nov;53(5):338–341. doi: 10.1007/BF01351840. [DOI] [PubMed] [Google Scholar]
  28. Rabinowitz M. B., Wetherill G. W., Kopple J. D. Lead metabolism in the normal human: stable isotope studies. Science. 1973 Nov 16;182(4113):725–727. doi: 10.1126/science.182.4113.725. [DOI] [PubMed] [Google Scholar]
  29. Sachs H. K., Moel D. I. Height and weight following lead poisoning in childhood. Am J Dis Child. 1989 Jul;143(7):820–822. doi: 10.1001/archpedi.1989.02150190070023. [DOI] [PubMed] [Google Scholar]
  30. Schwartz J., Angle C., Pitcher H. Relationship between childhood blood lead levels and stature. Pediatrics. 1986 Mar;77(3):281–288. [PubMed] [Google Scholar]
  31. Schwartz J. The relationship between blood lead and blood pressure in the NHANES II survey. Environ Health Perspect. 1988 Jun;78:15–22. doi: 10.1289/ehp.887815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Shapiro I. M., Needleman H. L., Tuncay O. C. The lead content of human deciduous and permanent teeth. Environ Res. 1972 Dec;5(4):467–470. doi: 10.1016/0013-9351(72)90047-3. [DOI] [PubMed] [Google Scholar]
  33. Shukla R., Bornschein R. L., Dietrich K. N., Buncher C. R., Berger O. G., Hammond P. B., Succop P. A. Fetal and infant lead exposure: effects on growth in stature. Pediatrics. 1989 Oct;84(4):604–612. [PubMed] [Google Scholar]
  34. Shukla R., Dietrich K. N., Bornschein R. L., Berger O., Hammond P. B. Lead exposure and growth in the early preschool child: a follow-up report from the Cincinnati Lead Study. Pediatrics. 1991 Nov;88(5):886–892. [PubMed] [Google Scholar]
  35. Somervaille L. J., Chettle D. R., Scott M. C. In vivo measurement of lead in bone using x-ray fluorescence. Phys Med Biol. 1985 Sep;30(9):929–943. doi: 10.1088/0031-9155/30/9/005. [DOI] [PubMed] [Google Scholar]
  36. Todd A. C., Chettle D. R. In vivo X-ray fluorescence of lead in bone: review and current issues. Environ Health Perspect. 1994 Feb;102(2):172–177. doi: 10.1289/ehp.94102172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Weiss S. T., Munoz A., Stein A., Sparrow D., Speizer F. E. The relationship of blood lead to systolic blood pressure in a longitudinal study of policemen. Environ Health Perspect. 1988 Jun;78:53–56. doi: 10.1289/ehp.887853. [DOI] [PMC free article] [PubMed] [Google Scholar]

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