Skip to main content
NCBI home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1995 Oct;103(10):888–890. doi: 10.1289/ehp.95103888

Are environmental sentinels signaling?

G A LeBlanc 1
PMCID: PMC1519157  PMID: 8529577

Abstract

There is an increasing perception that environmental contamination by chemicals no longer poses a significant health threat and that relaxation of environmental regulations is warranted. However, many wildlife populations are showing signs of developmental, behavioral, and reproductive dysfunction due to environmental contamination by endocrine-disrupting chemicals. Scientists, regulators, and legislators must mobilize to identify current health threats posed by environmental pollutants, develop testing protocols that will detect such properties of new chemicals, and strengthen legislation designed to protect environmental health.

Full text

PDF
888

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Black H. The price of progress: environmental health in Latin America. Environ Health Perspect. 1994 Dec;102(12):1024–1028. doi: 10.1289/ehp.102-1567472. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cassidy R. A., Vorhees C. V., Minnema D. J., Hastings L. The effects of chlordane exposure during pre- and postnatal periods at environmentally relevant levels on sex steroid-mediated behaviors and functions in the rat. Toxicol Appl Pharmacol. 1994 Jun;126(2):326–337. doi: 10.1006/taap.1994.1123. [DOI] [PubMed] [Google Scholar]
  3. Clay R. A continent in chaos: Africa's environmental issues. Environ Health Perspect. 1994 Dec;102(12):1018–1023. doi: 10.1289/ehp.941021018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cooper J. R., Vodicnik M. J., Gordon J. H. Effects of perinatal Kepone exposure on sexual differentiation of the rat brain. Neurotoxicology. 1985 Spring;6(1):183–190. [PubMed] [Google Scholar]
  5. Fry D. M., Toone C. K. DDT-induced feminization of gull embryos. Science. 1981 Aug 21;213(4510):922–924. doi: 10.1126/science.7256288. [DOI] [PubMed] [Google Scholar]
  6. Gellert R. J. Kepone, mirex, dieldrin, and aldrin: estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. Environ Res. 1978 Jul;16(1-3):131–138. doi: 10.1016/0013-9351(78)90150-0. [DOI] [PubMed] [Google Scholar]
  7. Gray L. E., Jr Neonatal chlordecone exposure alters behavioral sex differentiation in female hamsters. Neurotoxicology. 1982 Oct;3(2):67–79. [PubMed] [Google Scholar]
  8. Heckman W. R., Kane B. R., Pakyz R. E., Cosentino M. J. The effect of ketoconazole on endocrine and reproductive parameters in male mice and rats. J Androl. 1992 May-Jun;13(3):191–198. [PubMed] [Google Scholar]
  9. Hricko A. Environmental problems behind the Great Wall. Environ Health Perspect. 1994 Feb;102(2):154–159. doi: 10.1289/ehp.94102154. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hunsinger R. N., Howell W. M. Treatment of fish with hormones: solubilization and direct administration of steroids into aquaria water using acetone as a carrier solvent. Bull Environ Contam Toxicol. 1991 Aug;47(2):272–277. doi: 10.1007/BF01688651. [DOI] [PubMed] [Google Scholar]
  11. Hunt G. L., Jr, Hunt M. W. Female-Female Pairing in Western Gulls (Larus occidentalis) in Southern California. Science. 1977 Jun 24;196(4297):1466–1467. doi: 10.1126/science.196.4297.1466. [DOI] [PubMed] [Google Scholar]
  12. Kniewald J., Peruzović M., Gojmerac T., Milković K., Kniewald Z. Indirect influence of s-triazines on rat gonadotropic mechanism at early postnatal period. J Steroid Biochem. 1987;27(4-6):1095–1100. doi: 10.1016/0022-4731(87)90195-6. [DOI] [PubMed] [Google Scholar]
  13. Lundkvist U. Clinical and reproductive effects of Clophen A50 (PCB) administered during gestation on pregnant guinea pigs and their offspring. Toxicology. 1990 Apr 30;61(3):249–257. doi: 10.1016/0300-483x(90)90175-g. [DOI] [PubMed] [Google Scholar]
  14. McLachlan J. A. Functional toxicology: a new approach to detect biologically active xenobiotics. Environ Health Perspect. 1993 Oct;101(5):386–387. doi: 10.1289/ehp.93101386. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pelissero C., Flouriot G., Foucher J. L., Bennetau B., Dunoguès J., Le Gac F., Sumpter J. P. Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals. J Steroid Biochem Mol Biol. 1993 Mar;44(3):263–272. doi: 10.1016/0960-0760(93)90086-c. [DOI] [PubMed] [Google Scholar]
  16. Pont A., Williams P. L., Azhar S., Reitz R. E., Bochra C., Smith E. R., Stevens D. A. Ketoconazole blocks testosterone synthesis. Arch Intern Med. 1982 Nov;142(12):2137–2140. [PubMed] [Google Scholar]
  17. Ringel M., Bryan R. M., Vannucci R. C. Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers. Brain Res Dev Brain Res. 1991 Apr 24;59(2):231–235. doi: 10.1016/0165-3806(91)90103-p. [DOI] [PubMed] [Google Scholar]
  18. Ronis M. J., Ingelman-Sundberg M., Badger T. M. Induction, suppression and inhibition of multiple hepatic cytochrome P450 isozymes in the male rat and bobwhite quail (Colinus virginianus) by ergosterol biosynthesis inhibiting fungicides (EBIFs). Biochem Pharmacol. 1994 Nov 16;48(10):1953–1965. doi: 10.1016/0006-2952(94)90594-0. [DOI] [PubMed] [Google Scholar]
  19. Sierra V., Uphouse L. Long-term consequences of neonatal exposure to chlordecone. Neurotoxicology. 1986 Summer;7(2):609–621. [PubMed] [Google Scholar]
  20. Teng C. T., Liu Y., Yang N., Walmer D., Panella T. Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. Mol Endocrinol. 1992 Nov;6(11):1969–1981. doi: 10.1210/mend.6.11.1480183. [DOI] [PubMed] [Google Scholar]
  21. Vandenbergh J. G., Huggett C. L. Mother's prior intrauterine position affects the sex ratio of her offspring in house mice. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11055–11059. doi: 10.1073/pnas.91.23.11055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. vom Saal F. S., Bronson F. H. In utero proximity of female mouse fetuses to males: effect on reproductive performance during later life. Biol Reprod. 1978 Nov;19(4):842–853. doi: 10.1095/biolreprod19.4.842. [DOI] [PubMed] [Google Scholar]
  23. vom Saal F. S. Sexual differentiation in litter-bearing mammals: influence of sex of adjacent fetuses in utero. J Anim Sci. 1989 Jul;67(7):1824–1840. doi: 10.2527/jas1989.6771824x. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES