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. 1995 Feb;103(Suppl 1):111–113. doi: 10.1289/ehp.95103s1111

Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.

M E Gonsebatt 1, A M Salazar 1, R Montero 1, F Díaz Barriga 1, L Yáñez 1, H Gómez 1, P Ostrosky-Wegman 1
PMCID: PMC1519331  PMID: 7621789

Abstract

Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.

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Selected References

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