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. 1993 Apr;100:39–44. doi: 10.1289/ehp.9310039

Agricultural exposures and cancer trends in developed countries.

D L Davis 1, A Blair 1, D G Hoel 1
PMCID: PMC1519573  PMID: 8354180

Abstract

Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer mortality in industrial countries were reviewed to identify recently increasing sites and summaries were compiled of studies on farmers which have shown increased risks for these same sites of cancer. Using data provided by the World Health Organization, age-specific rates were developed for a number of sites of cancer from 1968 to 1986. Trends in the ratio of male to female cancer mortality were also assessed for several of these countries. Based on a literature review by the National Cancer Institute, patterns of cancer in farmers reported in 20 studies from 8 countries are summarized, weighting each study by its size to create combined relative risks. In industrial countries, rates of cancer mortality increased for a number of sites, including melanoma, prostate, non-Hodgkin's lymphoma, multiple myeloma, breast, brain, and kidney cancer. The ratio of male to female cancer mortality (for all sites of cancer excluding lung) has generally increased in several countries during this same time period. Many of the same sites that have increased in the general population have also been found to be increasing in farmers. Significant excesses occurred for Hodgkin's disease, multiple myeloma, leukemia, skin melanomas, and cancers of the lip, stomach, and prostate. Nonsignificant increases in risk were also noted for non-Hodgkin's lymphoma and cancers of connective tissue and brain in many surveys.(ABSTRACT TRUNCATED AT 250 WORDS)

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Selected References

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  1. Albanes D., Blair A., Taylor P. R. Physical activity and risk of cancer in the NHANES I population. Am J Public Health. 1989 Jun;79(6):744–750. doi: 10.2105/ajph.79.6.744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Blair A., Malker H., Cantor K. P., Burmeister L., Wiklund K. Cancer among farmers. A review. Scand J Work Environ Health. 1985 Dec;11(6):397–407. doi: 10.5271/sjweh.2208. [DOI] [PubMed] [Google Scholar]
  3. Blair A., Zahm S. H. Cancer among farmers. Occup Med. 1991 Jul-Sep;6(3):335–354. [PubMed] [Google Scholar]
  4. Blair S. N., Kohl H. W., 3rd, Paffenbarger R. S., Jr, Clark D. G., Cooper K. H., Gibbons L. W. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA. 1989 Nov 3;262(17):2395–2401. doi: 10.1001/jama.262.17.2395. [DOI] [PubMed] [Google Scholar]
  5. Blohmé I., Brynger H. Malignant disease in renal transplant patients. Transplantation. 1985 Jan;39(1):23–25. [PubMed] [Google Scholar]
  6. Boffetta P., Stellman S. D., Garfinkel L. A case-control study of multiple myeloma nested in the American Cancer Society prospective study. Int J Cancer. 1989 Apr 15;43(4):554–559. doi: 10.1002/ijc.2910430404. [DOI] [PubMed] [Google Scholar]
  7. Brown L. M., Blair A., Gibson R., Everett G. D., Cantor K. P., Schuman L. M., Burmeister L. F., Van Lier S. F., Dick F. Pesticide exposures and other agricultural risk factors for leukemia among men in Iowa and Minnesota. Cancer Res. 1990 Oct 15;50(20):6585–6591. [PubMed] [Google Scholar]
  8. Brownson R. C., Reif J. S., Chang J. C., Davis J. R. Cancer risks among Missouri farmers. Cancer. 1989 Dec 1;64(11):2381–2386. doi: 10.1002/1097-0142(19891201)64:11<2381::aid-cncr2820641131>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  9. Burmeister L. F. Cancer mortality in Iowa farmers, 1971-78. J Natl Cancer Inst. 1981 Mar;66(3):461–464. [PubMed] [Google Scholar]
  10. Cantor K. P., Blair A. Farming and mortality from multiple myeloma: a case-control study with the use of death certificates. J Natl Cancer Inst. 1984 Feb;72(2):251–255. [PubMed] [Google Scholar]
  11. Cassel J., Heyden S., Bartel A. G., Kaplan B. H., Tyroler H. A., Cornoni J. C., Hames C. G. Occupation and physical activity and coronary heart disease. Arch Intern Med. 1971 Dec;128(6):920–928. [PubMed] [Google Scholar]
  12. Davis D. L., Hoel D., Fox J., Lopez A. D. International trends in cancer mortality in France, West Germany, Italy, Japan, England and Wales, and the United States. Ann N Y Acad Sci. 1990;609:5–48. doi: 10.1111/j.1749-6632.1990.tb32055.x. [DOI] [PubMed] [Google Scholar]
  13. Delzell E., Grufferman S. Mortality among white and nonwhite farmers in North Carolina, 1976-1978. Am J Epidemiol. 1985 Mar;121(3):391–402. doi: 10.1093/oxfordjournals.aje.a114011. [DOI] [PubMed] [Google Scholar]
  14. Devesa S. S., Silverman D. T., Young J. L., Jr, Pollack E. S., Brown C. C., Horm J. W., Percy C. L., Myers M. H., McKay F. W., Fraumeni J. F., Jr Cancer incidence and mortality trends among whites in the United States, 1947-84. J Natl Cancer Inst. 1987 Oct;79(4):701–770. [PubMed] [Google Scholar]
  15. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981 Jun;66(6):1191–1308. [PubMed] [Google Scholar]
  16. Filipovich A. H., Spector B. D., Kersey J. Immunodeficiency in humans as a risk factor in the development of malignancy. Prev Med. 1980 Mar;9(2):252–259. doi: 10.1016/0091-7435(80)90083-3. [DOI] [PubMed] [Google Scholar]
  17. Flodin U., Fredriksson M., Persson B., Axelson O. Chronic lymphatic leukaemia and engine exhausts, fresh wood, and DDT: a case-referent study. Br J Ind Med. 1988 Jan;45(1):33–38. doi: 10.1136/oem.45.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Gallagher R. P., Threlfall W. J., Jeffries E., Band P. R., Spinelli J., Coldman A. J. Cancer and aplastic anemia in British Columbia farmers. J Natl Cancer Inst. 1984 Jun;72(6):1311–1315. [PubMed] [Google Scholar]
  19. Garabrant D. H., Peters J. M., Mack T. M., Bernstein L. Job activity and colon cancer risk. Am J Epidemiol. 1984 Jun;119(6):1005–1014. doi: 10.1093/oxfordjournals.aje.a113805. [DOI] [PubMed] [Google Scholar]
  20. Garrett N. E., Stack H. F., Waters M. D. Evaluation of the genetic activity profiles of 65 pesticides. Mutat Res. 1986 Nov;168(3):301–325. doi: 10.1016/0165-1110(86)90024-2. [DOI] [PubMed] [Google Scholar]
  21. Gerhardsson M., Norell S. E., Kiviranta H., Pedersen N. L., Ahlbom A. Sedentary jobs and colon cancer. Am J Epidemiol. 1986 May;123(5):775–780. doi: 10.1093/oxfordjournals.aje.a114306. [DOI] [PubMed] [Google Scholar]
  22. Hardell L., Eriksson M., Lenner P., Lundgren E. Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study. Br J Cancer. 1981 Feb;43(2):169–176. doi: 10.1038/bjc.1981.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hoar S. K., Blair A., Holmes F. F., Boysen C. D., Robel R. J., Hoover R., Fraumeni J. F., Jr Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. JAMA. 1986 Sep 5;256(9):1141–1147. [PubMed] [Google Scholar]
  24. Hoel D. G., Davis D. L., Miller A. B., Sondik E. J., Swerdlow A. J. Trends in cancer mortality in 15 industrialized countries, 1969-1986. J Natl Cancer Inst. 1992 Mar 4;84(5):313–320. doi: 10.1093/jnci/84.5.313. [DOI] [PubMed] [Google Scholar]
  25. Howe G. R., Lindsay J. P. A follow-up study of a ten-percent sample of the Canadian labor force. I. Cancer mortality in males, 1965-73. J Natl Cancer Inst. 1983 Jan;70(1):37–44. [PubMed] [Google Scholar]
  26. Lee J. A., Strickland D. Malignant melanoma: social status and outdoor work. Br J Cancer. 1980 May;41(5):757–763. doi: 10.1038/bjc.1980.138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Levine A. M. Lymphoma related to human immunodeficiency virus: the epidemic shifts. J Natl Cancer Inst. 1991 May 15;83(10):662–663. doi: 10.1093/jnci/83.10.662. [DOI] [PubMed] [Google Scholar]
  28. Lopez A. D. Competing causes of death. A review of recent trends in mortality in industrialized countries with special reference to cancer. Ann N Y Acad Sci. 1990;609:58–76. doi: 10.1111/j.1749-6632.1990.tb32057.x. [DOI] [PubMed] [Google Scholar]
  29. McMichael A. J., Hartshorne J. M. Mortality risks in Australian men by occupational groups, 1968-1978: variations associated with differences in drinking and smoking habits. Med J Aust. 1982 Mar 20;1(6):253–256. [PubMed] [Google Scholar]
  30. Musicco M., Sant M., Molinari S., Filippini G., Gatta G., Berrino F. A case-control study of brain gliomas and occupational exposure to chemical carcinogens: the risk to farmers. Am J Epidemiol. 1988 Oct;128(4):778–785. doi: 10.1093/oxfordjournals.aje.a115031. [DOI] [PubMed] [Google Scholar]
  31. Notkola V. J., Husman K. R., Laukkanen V. J. Mortality among male farmers in Finland during 1979-1983. Scand J Work Environ Health. 1987 Apr;13(2):124–128. doi: 10.5271/sjweh.2071. [DOI] [PubMed] [Google Scholar]
  32. Olsen J. H., Jensen O. M. Occupation and risk of cancer in Denmark. An analysis of 93,810 cancer cases, 1970-1979. Scand J Work Environ Health. 1987;13 (Suppl 1):1–91. [PubMed] [Google Scholar]
  33. Pearce N. E., Sheppard R. A., Smith A. H., Teague C. A. Non-Hodgkin's lymphoma and farming: an expanded case-control study. Int J Cancer. 1987 Feb 15;39(2):155–161. doi: 10.1002/ijc.2910390206. [DOI] [PubMed] [Google Scholar]
  34. Pearce N., Reif J. S. Epidemiologic studies of cancer in agricultural workers. Am J Ind Med. 1990;18(2):133–148. doi: 10.1002/ajim.4700180206. [DOI] [PubMed] [Google Scholar]
  35. Penn I. Immunosuppression and skin cancer. Clin Plast Surg. 1980 Jul;7(3):361–368. [PubMed] [Google Scholar]
  36. Persson B., Dahlander A. M., Fredriksson M., Brage H. N., Ohlson C. G., Axelson O. Malignant lymphomas and occupational exposures. Br J Ind Med. 1989 Aug;46(8):516–520. doi: 10.1136/oem.46.8.516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Pfeiffer S., Graham T. E., Webb R. D., Wilson B. A., Rivington-Moss E. G., Fisher-Ingram L. M. Aspects of physical fitness and health in Ontario dairy farmers. Can J Public Health. 1984 May-Jun;75(3):204–211. [PubMed] [Google Scholar]
  38. Rafnsson V., Gunnarsdóttir H. Mortality among farmers in Iceland. Int J Epidemiol. 1989 Mar;18(1):146–151. doi: 10.1093/ije/18.1.146. [DOI] [PubMed] [Google Scholar]
  39. Reif J., Pearce N., Fraser J. Cancer risks in New Zealand farmers. Int J Epidemiol. 1989 Dec;18(4):768–774. doi: 10.1093/ije/18.4.768. [DOI] [PubMed] [Google Scholar]
  40. Saftlas A. F., Blair A., Cantor K. P., Hanrahan L., Anderson H. A. Cancer and other causes of death among Wisconsin farmers. Am J Ind Med. 1987;11(2):119–129. doi: 10.1002/ajim.4700110202. [DOI] [PubMed] [Google Scholar]
  41. Stark A. D., Chang H. G., Fitzgerald E. F., Riccardi K., Stone R. R. A retrospective cohort study of mortality among New York State Farm Bureau members. Arch Environ Health. 1987 Jul-Aug;42(4):204–212. [PubMed] [Google Scholar]
  42. Wigle D. T., Semenciw R. M., Wilkins K., Riedel D., Ritter L., Morrison H. I., Mao Y. Mortality study of Canadian male farm operators: non-Hodgkin's lymphoma mortality and agricultural practices in Saskatchewan. J Natl Cancer Inst. 1990 Apr 4;82(7):575–582. doi: 10.1093/jnci/82.7.575. [DOI] [PubMed] [Google Scholar]
  43. Williams R. R., Stegens N. L., Goldsmith J. R. Associations of cancer site and type with occupation and industry from the Third National Cancer Survey Interview. J Natl Cancer Inst. 1977 Oct;59(4):1147–1185. doi: 10.1093/jnci/59.4.1147. [DOI] [PubMed] [Google Scholar]
  44. Witherspoon R. P., Fisher L. D., Schoch G., Martin P., Sullivan K. M., Sanders J., Deeg H. J., Doney K., Thomas D., Storb R. Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia. N Engl J Med. 1989 Sep 21;321(12):784–789. doi: 10.1056/NEJM198909213211203. [DOI] [PubMed] [Google Scholar]
  45. Zahm S. H., Weisenburger D. D., Babbitt P. A., Saal R. C., Vaught J. B., Cantor K. P., Blair A. A case-control study of non-Hodgkin's lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern Nebraska. Epidemiology. 1990 Sep;1(5):349–356. doi: 10.1097/00001648-199009000-00004. [DOI] [PubMed] [Google Scholar]

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