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. 1992 Nov;98:281–286. doi: 10.1289/ehp.9298281

The third United States-Japan meeting on the Toxicological Characterization of Environmental Chemicals.

Y Kurokawa 1, T Damstra 1
PMCID: PMC1519629  PMID: 1486859

Abstract

This report summarizes the discussion of the Third U.S.-Japan Meeting on the Toxicological Characterization of Environmental Chemicals held under the auspices of the U.S.-Japan cooperative in research and development in science and technology. Recent data on the interrelationships between toxicity, cell proliferation, and carcinogenicity are presented.

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Selected References

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  1. Ames B. N., Gold L. S. Chemical carcinogenesis: too many rodent carcinogens. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7772–7776. doi: 10.1073/pnas.87.19.7772. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ames B. N., Gold L. S. Too many rodent carcinogens: mitogenesis increases mutagenesis. Science. 1990 Aug 31;249(4972):970–971. doi: 10.1126/science.2136249. [DOI] [PubMed] [Google Scholar]
  3. Damstra T., Kurokawa Y. U.S.-Japan joint meeting on the toxicological characterization of environmental chemicals of mutual interest. Environ Health Perspect. 1990 Jul;87:301–307. doi: 10.1289/ehp.9087301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Harada T., Maronpot R. R., Morris R. W., Stitzel K. A., Boorman G. A. Morphological and stereological characterization of hepatic foci of cellular alteration in control Fischer 344 rats. Toxicol Pathol. 1989;17(4 Pt 1):579–593. doi: 10.1177/0192623389017004104. [DOI] [PubMed] [Google Scholar]
  5. Hayashi Y. Pathological implications of rat liver foci and relevance to regulatory decision-making: current status and future perspective. Toxicol Pathol. 1989;17(4 Pt 1):716–720. doi: 10.1177/0192623389017004116. [DOI] [PubMed] [Google Scholar]
  6. Hoel D. G., Haseman J. K., Hogan M. D., Huff J., McConnell E. E. The impact of toxicity on carcinogenicity studies: implications for risk assessment. Carcinogenesis. 1988 Nov;9(11):2045–2052. doi: 10.1093/carcin/9.11.2045. [DOI] [PubMed] [Google Scholar]
  7. Ito N., Imaida K., Hasegawa R., Tsuda H. Rapid bioassay methods for carcinogens and modifiers of hepatocarcinogenesis. Crit Rev Toxicol. 1989;19(4):385–415. doi: 10.3109/10408448909029328. [DOI] [PubMed] [Google Scholar]
  8. Kurokawa Y., Aoki S., Imazawa T., Hayashi Y., Matsushima Y., Takamura N. Dose-related enhancing effect of potassium bromate on renal tumorigenesis in rats initiated with N-ethyl-N-hydroxyethyl-nitrosamine. Jpn J Cancer Res. 1985 Jul;76(7):583–589. [PubMed] [Google Scholar]
  9. Kurokawa Y., Maekawa A., Takahashi M., Hayashi Y. Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen. Environ Health Perspect. 1990 Jul;87:309–335. doi: 10.1289/ehp.9087309. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Littlefield N. A., Gaylor D. W. Influence of total dose and dose rate in carcinogenicity studies. J Toxicol Environ Health. 1985;15(5):545–550. doi: 10.1080/15287398509530684. [DOI] [PubMed] [Google Scholar]
  11. Maekawa A., Matsushima Y., Onodera H., Shibutani M., Ogasawara H., Kodama Y., Kurokawa Y., Hayashi Y. Long-term toxicity/carcinogenicity of musk xylol in B6C3F1 mice. Food Chem Toxicol. 1990 Aug;28(8):581–586. doi: 10.1016/0278-6915(90)90159-k. [DOI] [PubMed] [Google Scholar]
  12. Maekawa A., Matsushima Y., Onodera H., Shibutani M., Yoshida J., Kodama Y., Kurokawa Y., Hayashi Y. Long-term toxicity/carcinogenicity study of calcium lactate in F344 rats. Food Chem Toxicol. 1991 Sep;29(9):589–594. doi: 10.1016/0278-6915(91)90139-x. [DOI] [PubMed] [Google Scholar]
  13. Maekawa A., Nagaoka T., Onodera H., Matsushima Y., Todate A., Shibutani M., Ogasawara H., Kodama Y., Hayashi Y. Two-year carcinogenicity study of 6-mercaptopurine in F344 rats. J Cancer Res Clin Oncol. 1990;116(3):245–250. doi: 10.1007/BF01612898. [DOI] [PubMed] [Google Scholar]
  14. Maekawa A., Ogiu T., Onodera H., Furuta K., Matsuoka C., Mochizuki M., Anjo T., Okada M., Odashima S. Carcinogenicity of N-alkyl-N-(acetoxymethyl)nitrosamines after subcutaneous injections in F-344 rats. J Cancer Res Clin Oncol. 1982;104(1-2):13–21. doi: 10.1007/BF00402049. [DOI] [PubMed] [Google Scholar]
  15. Maekawa A., Takahashi M., Kurokawa Y., Kokubo T., Ogiu T., Odashima S., Mochizuki M., Anjo T., Okada M. Carcinogenicity of alpha-oxidized nitrosamines (alpha-acyloxy, alpha-hydroperoxy, and alpha-oxo nitrosamines) in F-344 rats. IARC Sci Publ. 1982;(41):619–624. [PubMed] [Google Scholar]
  16. Maekawa A., Todate A., Onodera H., Matsushima Y., Nagaoka T., Shibutani M., Ogasawara H., Kodama Y., Hayashi Y. Lack of toxicity/carcinogenicity of monosodium succinate in F344 rats. Food Chem Toxicol. 1990 Apr;28(4):235–241. doi: 10.1016/0278-6915(90)90035-l. [DOI] [PubMed] [Google Scholar]
  17. Maronpot R. R., Shimkin M. B., Witschi H. P., Smith L. H., Cline J. M. Strain A mouse pulmonary tumor test results for chemicals previously tested in the National Cancer Institute carcinogenicity tests. J Natl Cancer Inst. 1986 Jun;76(6):1101–1112. [PubMed] [Google Scholar]
  18. Sato H., Takahashi M., Furukawa F., Miyakawa Y., Hasegawa R., Toyoda K., Hayashi Y. Initiating activity in a two-stage mouse skin model of nine mutagenic pyrolysates of amino acids, soybean globulin and proteinaceous food. Carcinogenesis. 1987 Sep;8(9):1231–1234. doi: 10.1093/carcin/8.9.1231. [DOI] [PubMed] [Google Scholar]
  19. Sato H., Takahashi M., Furukawa F., Miyakawa Y., Hasegawa R., Toyoda K., Hayashi Y. Initiating potential of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and 3,3',4',5,7-pentahydroxyflavone (quercetin) in two-stage mouse skin carcinogenesis. Cancer Lett. 1987 Dec;38(1-2):49–56. doi: 10.1016/0304-3835(87)90199-6. [DOI] [PubMed] [Google Scholar]
  20. Sato H., Toyoda K., Takamura N., Furukawa F., Hasegawa R., Fukuoka M., Imaida K., Takahashi M., Hayashi Y. Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis. Cancer Lett. 1990 Dec 17;55(3):233–238. doi: 10.1016/0304-3835(90)90124-g. [DOI] [PubMed] [Google Scholar]
  21. Shelby M. D., Sofuni T. Toxicology testing requirements and the U.S.-Japan collaborative study on in vitro tests for chromosomal aberrations. Environ Health Perspect. 1991 Aug;94:255–259. doi: 10.1289/ehp.94-1567941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Shibata M. A., Tamano S., Kurata Y., Hagiwara A., Fukushima S. Participation of urinary Na+, K+, pH, and L-ascorbic acid in the proliferative response of the bladder epithelium after the oral administration of various salts and/or ascorbic acid to rats. Food Chem Toxicol. 1989 Jun;27(6):403–413. doi: 10.1016/0278-6915(89)90147-6. [DOI] [PubMed] [Google Scholar]
  23. Shibata M. A., Yamada M., Asakawa E., Hagiwara A., Fukushima S. Responses of rat urine and urothelium to bladder tumor promoters: possible roles of prostaglandin E2 and ascorbic acid synthesis in bladder carcinogenesis. Carcinogenesis. 1989 Sep;10(9):1651–1656. doi: 10.1093/carcin/10.9.1651. [DOI] [PubMed] [Google Scholar]
  24. Shibata M. A., Yamada M., Tanaka H., Kagawa M., Fukushima S. Changes in urine composition, bladder epithelial morphology, and DNA synthesis in male F344 rats in response to ingestion of bladder tumor promoters. Toxicol Appl Pharmacol. 1989 Jun 1;99(1):37–49. doi: 10.1016/0041-008x(89)90109-9. [DOI] [PubMed] [Google Scholar]
  25. Takahashi M., Kurokawa Y., Maekawa A., Kokubo T., Furukawa F., Mochizuki M., Anjo T., Okada M. Comparative carcinogenicities of model compounds of metabolically activated N,N-dibutylnitrosamine in rats. Gan. 1982 Oct;73(5):687–694. [PubMed] [Google Scholar]
  26. Takahashi M., Sato H., Toyoda K., Furukawa F., Imaida K., Hasegawa R., Hayashi Y. Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 1989 Jul;10(7):1163–1167. doi: 10.1093/carcin/10.7.1163. [DOI] [PubMed] [Google Scholar]
  27. Tanaka S., Kawashima K., Naito K., Usami M., Nakadate M., Imaida K., Takahashi M., Hayashi Y., Kurokawa Y., Tobe M. Combined Repeat Dose and Reproductive/Developmental Toxicity Screening Test (OECD): familiarization using cyclophosphamide. Fundam Appl Toxicol. 1992 Jan;18(1):89–95. doi: 10.1016/0272-0590(92)90199-r. [DOI] [PubMed] [Google Scholar]
  28. Tennant R. W., Ashby J. Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals tested for carcinogenicity by the U.S. National Toxicology Program. Mutat Res. 1991 May;257(3):209–227. doi: 10.1016/0165-1110(91)90002-d. [DOI] [PubMed] [Google Scholar]

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