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. 1993 Dec;101(Suppl 6):77–84. doi: 10.1289/ehp.93101s677

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

L Rushton 1
PMCID: PMC1520001  PMID: 8020451

Abstract

This paper presents briefly some of the principal results of a mortality analysis of a cohort of workers employed for at least 1 year between 1950 and 1975 at eight oil refineries and approximately 750 distribution centers in the U.K., together with detailed results for kidney cancer and leukemia. Over 99% of the workers were successfully traced. Their mortality was compared with that of all males in the national population. The mortality from all causes of death is lower than that of the comparison population in both studies, and reduced mortality is also found for many of the major nonmalignant causes of death. In the refinery study, some increased mortality patterns are found for diseases of the arteries, and no healthy worker effect is found in the distribution center study for ischemic heart disease. Mortality from all neoplasms is lower than expected overall in both studies, largely due to a deficit of deaths from malignant neoplasm of the lung. Mortality from malignant neoplasm of the kidney is increased overall in the distribution center study, and in drivers in particular. The mortality from this disease increases with increased time since first exposure. The observed deaths from leukemia are slightly less than expected in the refinery study and slightly more than expected in the distribution center study. One refinery shows increased mortality due to in myeloid leukemia, and mortality is increased among refinery operators. Mortality is also raised in distribution center drivers, particularly for myeloid leukemias, including acute myeloid leukemia.

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Selected References

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  1. Austin H., Delzell E., Cole P. Benzene and leukemia. A review of the literature and a risk assessment. Am J Epidemiol. 1988 Mar;127(3):419–439. doi: 10.1093/oxfordjournals.aje.a114820. [DOI] [PubMed] [Google Scholar]
  2. Blattner W. A., Blair A., Mason T. J. Multiple myeloma in the United States, 1950--1975. Cancer. 1981 Dec 1;48(11):2547–2554. doi: 10.1002/1097-0142(19811201)48:11<2547::aid-cncr2820481134>3.0.co;2-i. [DOI] [PubMed] [Google Scholar]
  3. Blot W. J., Brinton L. A., Fraumeni J. F., Jr, Stone B. J. Cancer mortality in U.S. counties with petroleum industries. Science. 1977 Oct 7;198(4312):51–53. doi: 10.1126/science.897679. [DOI] [PubMed] [Google Scholar]
  4. Decoufle P. Further analysis of cancer mortality patterns among workers exposed to cutting oil mists. J Natl Cancer Inst. 1978 Oct;61(4):1025–1030. [PubMed] [Google Scholar]
  5. Divine B. J., Barron V. Texaco Mortality Study: II. Patterns of mortality among white males by specific job groups. Am J Ind Med. 1986;10(4):371–381. doi: 10.1002/ajim.4700100405. [DOI] [PubMed] [Google Scholar]
  6. Divine B. J., Barron V. Texaco mortality study: III. A cohort study of producing and pipeline workers. Am J Ind Med. 1987;11(2):189–202. doi: 10.1002/ajim.4700110208. [DOI] [PubMed] [Google Scholar]
  7. Domiano S. F., Vena J. E., Swanson M. K. Gasoline exposure, smoking, and kidney cancer. J Occup Med. 1985 Jun;27(6):398–399. [PubMed] [Google Scholar]
  8. Enterline P. E., Viren J. Epidemiologic evidence for an association between gasoline and kidney cancer. Environ Health Perspect. 1985 Oct;62:303–312. doi: 10.1289/ehp.8562303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Finn R., Fennerty A. G., Ahmad R. Hydrocarbon exposure and glomerulonephritis. Clin Nephrol. 1980 Oct;14(4):173–175. [PubMed] [Google Scholar]
  10. GILMAN J. P., VESSELINOVITCH S. D. Cutting oils and squamous-cell carcinoma. II. An experimental study of the carcinogenicity of two types of cutting oils. Br J Ind Med. 1955 Jul;12(3):244–248. doi: 10.1136/oem.12.3.244. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gottlieb M. S., Pickle L. W., Blot W. J., Fraumeni J. F., Jr Lung cancer in Louisiana: death certificate analysis. J Natl Cancer Inst. 1979 Nov;63(5):1131–1137. [PubMed] [Google Scholar]
  12. Gradiski D., Vinot J., Zissu D., Limasset J. C., Lafontaine M. The carcinogenic effect of a series of petroleum-derived oils on the skin of mice. Environ Res. 1983 Dec;32(2):258–268. doi: 10.1016/0013-9351(83)90110-x. [DOI] [PubMed] [Google Scholar]
  13. Hanis N. M., Stavraky K. M., Fowler J. L. Cancer mortality in oil refinery workers. J Occup Med. 1979 Mar;21(3):167–174. [PubMed] [Google Scholar]
  14. Harrington J. M. Health experience of workers in the petroleum manufacturing and distribution industry: a review of the literature. Am J Ind Med. 1987;12(5):475–497. doi: 10.1002/ajim.4700120503. [DOI] [PubMed] [Google Scholar]
  15. Holland J. M., Rahn R. O., Smith L. H., Clark B. R., Chang S. S., Stephens T. J. Skin carcinogenicity of synthetic and natural petroleums. J Occup Med. 1979 Sep;21(9):614–618. [PubMed] [Google Scholar]
  16. Hoover R., Fraumeni J. F., Jr Cancer mortality in U.S. counties with chemical industries. Environ Res. 1975 Apr;9(2):196–207. doi: 10.1016/0013-9351(75)90064-x. [DOI] [PubMed] [Google Scholar]
  17. Irving W. S., Jr, Grumbles T. G. Benzene exposures during gasoline loading at bulk marketing terminals. Am Ind Hyg Assoc J. 1979 Jun;40(6):468–473. doi: 10.1080/15298667991429840. [DOI] [PubMed] [Google Scholar]
  18. Järvholm B., Lavenius B. Mortality and cancer morbidity in workers exposed to cutting fluids. Arch Environ Health. 1987 Nov-Dec;42(6):361–366. doi: 10.1080/00039896.1987.9934360. [DOI] [PubMed] [Google Scholar]
  19. Kaldor J., Harris J. A., Glazer E., Glaser S., Neutra R., Mayberry R., Nelson V., Robinson L., Reed D. Statistical association between cancer incidence and major-cause mortality, and estimated residential exposure to air emissions from petroleum and chemical plants. Environ Health Perspect. 1984 Mar;54:319–332. doi: 10.1289/ehp.8454319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. McCraw D. S., Joyner R. E., Cole P. Excess leukemia in a refinery population. J Occup Med. 1985 Mar;27(3):220–222. [PubMed] [Google Scholar]
  21. McDermott H. J., Vos G. A. Service station attendants' exposure to benzene and gasoline vapors. Am Ind Hyg Assoc J. 1979 Apr;40(4):315–321. doi: 10.1080/15298667991429642. [DOI] [PubMed] [Google Scholar]
  22. McLaughlin J. K., Blot W. J., Mehl E. S., Stewart P. A., Venable F. S., Fraumeni J. F., Jr Petroleum-related employment and renal cell cancer. J Occup Med. 1985 Sep;27(9):672–674. [PubMed] [Google Scholar]
  23. Mehlman M. A. Dangerous properties of petroleum-refining products: carcinogenicity of motor fuels (gasoline). Teratog Carcinog Mutagen. 1990;10(5):399–408. doi: 10.1002/tcm.1770100505. [DOI] [PubMed] [Google Scholar]
  24. Miller B. G., Cowie H. A., Middleton W. G., Seaton A. Epidemiologic studies of Scottish oil shale workers: III. Causes of death. Am J Ind Med. 1986;9(5):433–446. doi: 10.1002/ajim.4700090505. [DOI] [PubMed] [Google Scholar]
  25. Moss E., Scott T. S., Atherley G. R. Mortality of newspaper workers from lung cancer and bronchitis 1952-66. Br J Ind Med. 1972;29(1):1–14. doi: 10.1136/oem.29.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Nelson N. A., Van Peenen P. F., Blanchard A. G. Mortality in a recent oil refinery cohort. J Occup Med. 1987 Jul;29(7):610–612. [PubMed] [Google Scholar]
  27. Page N. P., Mehlman M. Health effects of gasoline refueling vapors and measured exposures at service stations. Toxicol Ind Health. 1989 Oct;5(5):869–890. doi: 10.1177/074823378900500521. [DOI] [PubMed] [Google Scholar]
  28. Pandya K. P., Rao G. S., Dhasmana A., Zaidi S. H. Occupational exposure of petrol pump workers. Ann Occup Hyg. 1975 Dec;18(4):363–364. doi: 10.1093/annhyg/18.4.363. [DOI] [PubMed] [Google Scholar]
  29. Pasternack B., Ehrlich L. Occupational exposure to an oil mist atmosphere. A 12-year mortality study. Arch Environ Health. 1972 Oct;25(4):286–294. doi: 10.1080/00039896.1972.10666175. [DOI] [PubMed] [Google Scholar]
  30. Phillips C. F., Jones R. K. Gasoline vapor exposure during bulk handling operations. Am Ind Hyg Assoc J. 1978 Feb;39(2):118–128. doi: 10.1080/0002889778507725. [DOI] [PubMed] [Google Scholar]
  31. Ravnskov U. Exposure to organic solvents--a missing link in poststreptococcal glomerulonephritis? Acta Med Scand. 1978;203(5):351–356. doi: 10.1111/j.0954-6820.1978.tb14888.x. [DOI] [PubMed] [Google Scholar]
  32. Ravnskov U., Forsberg B., Skerfving S. Glomerulonephritis and exposure to organic solvents. A case-control study. Acta Med Scand. 1979;205(7):575–579. doi: 10.1111/j.0954-6820.1979.tb06106.x. [DOI] [PubMed] [Google Scholar]
  33. Reeve G. R., Bond G. G., Lloyd J. W., Cook R. R., Waxweiler R. J., Fishbeck W. A. An investigation of brain tumors among chemical plant employees using a sample-based cohort method. J Occup Med. 1983 May;25(5):387–393. [PubMed] [Google Scholar]
  34. Rushton L., Alderson M. R. A case-control study to investigate the association between exposure to benzene and deaths from leukaemia in oil refinery workers. Br J Cancer. 1981 Jan;43(1):77–84. doi: 10.1038/bjc.1981.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Rushton L., Alderson M. R. An epidemiological survey of eight oil refineries in Britain. Br J Ind Med. 1981 Aug;38(3):225–234. doi: 10.1136/oem.38.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Rushton L., Alderson M. R. Epidemiological survey of oil distribution centres in Britain. Br J Ind Med. 1983 Aug;40(3):330–339. doi: 10.1136/oem.40.3.330. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Savitz D. A., Moure R. Cancer risk among oil refinery workers. A review of epidemiologic studies. J Occup Med. 1984 Sep;26(9):662–670. [PubMed] [Google Scholar]
  38. Schwartz E. Proportionate mortality ratio analysis of automobile mechanics and gasoline service station workers in New Hampshire. Am J Ind Med. 1987;12(1):91–99. doi: 10.1002/ajim.4700120110. [DOI] [PubMed] [Google Scholar]
  39. Sherwood R. J. Evaluation of exposure to benzene vapour during the loading of petrol. Br J Ind Med. 1972;29(1):65–69. doi: 10.1136/oem.29.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Siemiatycki J., Wacholder S., Dewar R., Cardis E., Greenwood C., Richardson L. Degree of confounding bias related to smoking, ethnic group, and socioeconomic status in estimates of the associations between occupation and cancer. J Occup Med. 1988 Aug;30(8):617–625. doi: 10.1097/00043764-198808000-00004. [DOI] [PubMed] [Google Scholar]
  41. Swaen G. M., Meijers J. M. Risk assessment of leukaemia and occupational exposure to benzene. Br J Ind Med. 1989 Dec;46(12):826–830. doi: 10.1136/oem.46.12.826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Thomas T. L., Waxweiler R. J., Crandall M. S., White D. W., Moure-Eraso R., Fraumeni J. F., Jr Cancer mortality patterns by work category in three Texas oil refineries. Am J Ind Med. 1984;6(1):3–16. doi: 10.1002/ajim.4700060103. [DOI] [PubMed] [Google Scholar]
  43. Van Peenen P. F., Blanchard A. G., Wolkonsky P. M. Smoking habits of oil refinery employees. Am J Public Health. 1984 Dec;74(12):1408–1409. doi: 10.2105/ajph.74.12.1408. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Wen C. P., Tsai S. P., McClellan W. A., Gibson R. L. Long-term mortality study of oil refinery workers. I. Mortality of hourly and salaried workers. Am J Epidemiol. 1983 Oct;118(4):526–542. doi: 10.1093/oxfordjournals.aje.a113658. [DOI] [PubMed] [Google Scholar]
  45. Wen C. P., Tsai S. P., Weiss N. S., Gibson R. L. Long-term mortality study of oil refinery workers: V. Comparison of workers hired before, during, and after World War II (1940-1945) with a discussion of the impact of study designs on cohort results. Am J Ind Med. 1986;9(2):171–180. doi: 10.1002/ajim.4700090208. [DOI] [PubMed] [Google Scholar]
  46. Wong O., Morgan R. W., Bailey W. J., Swencicki R. E., Claxton K., Kheifets L. An epidemiological study of petroleum refinery employees. Br J Ind Med. 1986 Jan;43(1):6–17. doi: 10.1136/oem.43.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Wong O., Morgan R. W., Kheifets L., Larson S. R., Whorton M. D. Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. Br J Ind Med. 1985 Jul;42(7):435–448. doi: 10.1136/oem.42.7.435. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Wong O., Raabe G. K. Critical review of cancer epidemiology in petroleum industry employees, with a quantitative meta-analysis by cancer site. Am J Ind Med. 1989;15(3):283–310. doi: 10.1002/ajim.4700150305. [DOI] [PubMed] [Google Scholar]
  49. Wong O., Rockette H. E., Redmond C. K., Heid M. Evaluation of multiple causes of death in occupational mortality studies. J Chronic Dis. 1978 Mar;31(3):183–193. doi: 10.1016/0021-9681(78)90033-4. [DOI] [PubMed] [Google Scholar]
  50. Zimmerman S. W., Groehler K., Beirne G. J. Hydrocarbon exposure and chronic glomerulonephritis. Lancet. 1975 Aug 2;2(7927):199–201. doi: 10.1016/s0140-6736(75)90671-6. [DOI] [PubMed] [Google Scholar]
  51. de Silva P. E., Donnan M. B. Petrol vendors, capillary blood lead levels and contamination. Med J Aust. 1977 Mar 5;1(10):344–347. [PubMed] [Google Scholar]

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