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. 1993 Oct;101(Suppl 3):155–158. doi: 10.1289/ehp.101-1521117

Monitoring genotoxic exposure in uranium mines.

R J Srám 1, L Dobiás 1, P Rössner 1, D Veselá 1, D Veselý 1, R Rakusová 1, V Rericha 1
PMCID: PMC1521117  PMID: 8143610

Abstract

Recent data from deep uranium mines in Czechoslovakia indicated that mines are exposed to other mutagenic factors in addition to radon daughter products. Mycotoxins were identified as a possible source of mutagens in these mines. Mycotoxins were examined in 38 samples from mines and in throat swabs taken from 116 miners and 78 controls. The following mycotoxins were identified from mines samples: aflatoxins B1 and G1, citrinin, citreoviridin, mycophenolic acid, and sterigmatocystin. Some mold strains isolated from mines and throat swabs were investigated for mutagenic activity by the SOS chromotest and Salmonella assay with strains TA100 and TA98. Mutagenicity was observed, especially with metabolic activation in vitro. These data suggest that mycotoxins produced by molds in uranium mines are a new genotoxic factor for uranium miners.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames B. N., Mccann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res. 1975 Dec;31(6):347–364. doi: 10.1016/0165-1161(75)90046-1. [DOI] [PubMed] [Google Scholar]
  2. Auffray Y., Boutibonnes P. Evaluation of the genotoxic activity of some mycotoxins using Escherichia coli in the SOS spot test. Mutat Res. 1986 Aug-Sep;171(2-3):79–82. doi: 10.1016/0165-1218(86)90038-8. [DOI] [PubMed] [Google Scholar]
  3. Boutibonnes P., Auffray Y., Malherbe C., Kogbo W., Marais C. Propriétés antibactériennes et génotoxiques de 33 mycotoxines. Mycopathologia. 1984 Aug 30;87(1-2):43–49. doi: 10.1007/BF00436626. [DOI] [PubMed] [Google Scholar]
  4. Kusák V. Ethiopathogenesis of bronchogenic pulmonar carcinoma in miners from uranium mines. Strahlentherapie. 1969 Nov;138(5):549–555. [PubMed] [Google Scholar]
  5. Kusák V., Jelínek S., Sula J. Possible role of Aspergillus flavus in the pathogenesis of Schneeberg and Jáchymov disease. Neoplasma. 1970;17(5):441–449. [PubMed] [Google Scholar]
  6. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  7. Maron D. M., Ames B. N. Revised methods for the Salmonella mutagenicity test. Mutat Res. 1983 May;113(3-4):173–215. doi: 10.1016/0165-1161(83)90010-9. [DOI] [PubMed] [Google Scholar]
  8. Quillardet P., Hofnung M. The SOS Chromotest, a colorimetric bacterial assay for genotoxins: procedures. Mutat Res. 1985 Jun;147(3):65–78. doi: 10.1016/0165-1161(85)90020-2. [DOI] [PubMed] [Google Scholar]
  9. Sevc J., Kunz E., Tomásek L., Placek V., Horácek J. Cancer in man after exposure to Rn daughters. Health Phys. 1988 Jan;54(1):27–46. doi: 10.1097/00004032-198801000-00001. [DOI] [PubMed] [Google Scholar]
  10. Srám R. J., Binková B., Dobiás L., Rössner P., Topinka J., Veselá D., Veselý D., Stejskalová J., Bavorová H., Rericha V. Monitoring genotoxic exposure in uranium miners. Environ Health Perspect. 1993 Mar;99:303–305. doi: 10.1289/ehp.99-1567033. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Stark A. A. Mutagenicity and carcinogenicity of mycotoxins: DNA binding as a possible mode of action. Annu Rev Microbiol. 1980;34:235–262. doi: 10.1146/annurev.mi.34.100180.001315. [DOI] [PubMed] [Google Scholar]
  12. Veselý D., Veselá D., Jelínek R. Use of chick embryo in screening for toxin-producing fungi. Mycopathologia. 1984 Dec 30;88(2-3):135–140. doi: 10.1007/BF00436444. [DOI] [PubMed] [Google Scholar]
  13. Zennie T. M. Identification of aflatoxin B1 in grain elevator dusts in central Illinois. J Toxicol Environ Health. 1984;13(4-6):589–593. doi: 10.1080/15287398409530523. [DOI] [PubMed] [Google Scholar]

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