Abstract
Spontaneous frequencies of sister chromatid exchanges (SCEs) and SCEs induced in vitro by chemicals with different mechanisms of action such as mitomycin C, 4-nitroquinoline oxide, and 3-aminobenzamide were examined in phytohemagglutinin-stimulated peripheral blood lymphocytes from a group of workers in a rubber plant and a control group, both of which had been analyzed for levels of spontaneous SCEs 2 years earlier. An interindividual variability in the induction of SCEs was found after in vitro treatments with the different mutagens, which did not correlate with occupational exposure. This variability in the sensitivity to the induction of SCEs might be correlated to genetic differences among individuals, which have to be taken into account in environmental monitoring programs.
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Selected References
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- Bauchinger M., Schmid E., Dresp J., Kolin-Gerresheim J., Hauf R., Suhr E. Chromosome changes in lymphocytes after occupational exposure to toluene. Mutat Res. 1982 Dec;102(4):439–445. doi: 10.1016/0165-1218(82)90106-9. [DOI] [PubMed] [Google Scholar]
- Benigni R., Calcagnile A., Fabri G., Giuliani A., Leopardi P., Paoletti A. Biological monitoring of workers in the rubber industry. II. UV-induced unscheduled DNA synthesis in the lymphocytes of vulcanizers. Mutat Res. 1984 Oct;138(1):105–111. doi: 10.1016/0165-1218(84)90092-2. [DOI] [PubMed] [Google Scholar]
- Carrano A. V., Natarajan A. T. International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat Res. 1988 Mar;204(3):379–406. doi: 10.1016/0165-1218(88)90036-5. [DOI] [PubMed] [Google Scholar]
- Degrassi F., Fabri G., Palitti F., Paoletti A., Ricordy R., Tanzarella C. Biological monitoring of workers in the rubber industry. I. Chromosomal aberrations and sister-chromatid exchanges in lymphocytes of vulcanizers. Mutat Res. 1984 Oct;138(1):99–103. doi: 10.1016/0165-1218(84)90091-0. [DOI] [PubMed] [Google Scholar]
- Kucerová M., Polívková Z., Bátora J. Comparative evaluation of the frequency of chromosomal aberrations and the SCE numbers in peripheral lymphocytes of workers occupationally exposed to vinyl chloride monomer. Mutat Res. 1979 May;67(1):97–100. doi: 10.1016/0165-1218(79)90105-8. [DOI] [PubMed] [Google Scholar]
- Murli H., Galloway S. M., Ivett J. L., Parry D. M., Mulvihill J. J. Baseline and mutagen-induced sister-chromatid exchanges in cultures of human whole blood and purified fresh or frozen lymphocytes. Mutat Res. 1987 Sep;180(1):101–108. doi: 10.1016/0027-5107(87)90072-8. [DOI] [PubMed] [Google Scholar]
- Oikawa A., Sakai S., Horaguchi K., Tohda H. Sensitivities of peripheral lymphocytes from healthy humans to induction of sister chromatid exchanges by chemicals. Cancer Res. 1983 Jan;43(1):439–442. [PubMed] [Google Scholar]
- Palitti F., Tanzarella C., Cozzi R., Ricordy R., Vitagliano E., Fiore M. Comparison of the frequencies of SCEs induced by chemical mutagens in bone-marrow, spleen and spermatogonial cells of mice. Mutat Res. 1982 Feb;103(2):191–195. doi: 10.1016/0165-7992(82)90028-8. [DOI] [PubMed] [Google Scholar]
- Schwartz S., Astemborski J. A., Budacz A. P., Boughman J. A., Wasserman S. S., Cohen M. M. Repeated measurement of spontaneous and clastogen-induced sister-chromatid exchange. Mutat Res. 1990 Apr;234(2):51–59. doi: 10.1016/0165-1161(90)90031-i. [DOI] [PubMed] [Google Scholar]