Abstract
The author advances the concept that anoxemia, either in its general or restricted form, or both, is probably responsible for a considerable portion of “degenerative diseases,” whose etiologic delineation has not yet been traced. It is necessary, he believes, to enlarge greatly the comprehension of the disordered circulatory states to include oxygen want and thereby account for a number of conditions hitherto considered to be of unknown cause. More than this, he finds in oxygen want an explanation of the mechanism of a number of individual lesions or details of lesions otherwise not well understood. The author believes it is very likely that an understanding of cerebral anoxia in its ultimate ramifications will open still wider doors to the understanding of certain clinical syndromes the cause of which remains obscure.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- COURVILLE C. B. Contributions to the study of cerebral anoxia. III. Neonatal asphyxia and its relation to certain degenerative diseases of the brain in infancy and childhood. Bull Los Angel Neuro Soc. 1950 Sep;15(3):155–195. [PubMed] [Google Scholar]
- COURVILLE C. B., NIELSEN J. M. Cerebral anoxia and convulsive disorders; some observations on the effects of oxygen want as a significant factor in the causation of epilepsy. Bull Los Angel Neuro Soc. 1953 Jun;18(2):59–73. [PubMed] [Google Scholar]
- COURVILLE C. B. Ultimate residual lesions of antenatal and neonatal asphyxia; their relation to certain degenerative diseases of the brain appearing in early life. AMA Am J Dis Child. 1952 Jul;84(1):64–78. doi: 10.1001/archpedi.1952.02050010080008. [DOI] [PubMed] [Google Scholar]
- Courville C. B. THE PATHOGENESIS OF NECROSIS OF THE CEREBRAL GRAY MATTER FOLLOWING NITROUS OXIDE ANESTHESIA. Ann Surg. 1938 Mar;107(3):371–379. doi: 10.1097/00000658-193803000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MALAMUD N. Status marmoratus; a form of cerebral palsy following either birth injury or inflammation of the central nervous system. J Pediatr. 1950 Oct;37(4):610–619. doi: 10.1016/s0022-3476(50)80272-x. [DOI] [PubMed] [Google Scholar]
