Skip to main content
Journal of Clinical Pathology. Supplement (Royal College of Pathologists) logoLink to Journal of Clinical Pathology. Supplement (Royal College of Pathologists)
. 1977;11:94–104. doi: 10.1136/jcp.s3-11.1.94

Ischaemia of peripheral nerve and muscle.

D G Harriman
PMCID: PMC1522203  PMID: 269124

Abstract

Although skeletal muscle and peripheral nerves are both resistant to ischaemia there are nevertheless many syndromes in which they are affected, either separately or together. It is frequently difficult to distinguish the effects of arterial ischaemia from those of compression, which may operate through vascular occlusion, or, in the case of peripheral nerve, by mechanical deformation of nerve fibres. A great deal has been learned from experimental models, but not all of it is applicable to the complexity of human neuromuscular ischaemia which requires further study.

Full text

PDF
94

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen P. Capillary density in skeletal muscle of man. Acta Physiol Scand. 1975 Oct;95(2):203–205. doi: 10.1111/j.1748-1716.1975.tb10043.x. [DOI] [PubMed] [Google Scholar]
  2. BRICE J. G., DOWSETT D. J., LOWE R. D. HAEMODYNAMIC EFFECTS OF CAROTID ARTERY STENOSIS. Br Med J. 1964 Nov 28;2(5421):1363–1366. doi: 10.1136/bmj.2.5421.1363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Boehme D., Themann H., Gold J. Structural and ultrastructural changes in striated human muscle caused by chronic ischemia. Am J Pathol. 1966 Sep;49(3):569–591. [PMC free article] [PubMed] [Google Scholar]
  4. Bradley E. L., 3rd The anterior tibial compartment syndrome. Surg Gynecol Obstet. 1973 Feb;136(2):289–297. [PubMed] [Google Scholar]
  5. Bywaters E. G., Delory G. E., Rimington C., Smiles J. Myohaemoglobin in the urine of air raid casualties with crushing injury. Biochem J. 1941 Nov;35(10-11):1164–1168. doi: 10.1042/bj0351164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Clark J. G., Sumerling M. D. Muscle necrosis and calcification in acute renal failure due to barbiturate intoxication. Br Med J. 1966 Jul 23;2(5507):214–215. doi: 10.1136/bmj.2.5507.214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dyck P. J., Lambert E. H., O'Brien P. C. Pain in peripheral neuropathy related to rate and kind of fiber degeneration. Neurology. 1976 May;26(5):466–471. doi: 10.1212/wnl.26.5.466. [DOI] [PubMed] [Google Scholar]
  8. Eames R. A., Lange L. S. Clinical and pathological study of ischaemic neuropathy. J Neurol Neurosurg Psychiatry. 1967 Jun;30(3):215–226. doi: 10.1136/jnnp.30.3.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FULLERTON P. M. THE EFFECT OF ISCHAEMIA ON NERVE CONDUCTION IN THE CARPAL TUNNEL SYNDROME. J Neurol Neurosurg Psychiatry. 1963 Oct;26:385–397. doi: 10.1136/jnnp.26.5.385. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fox J. L., Kenmore P. I. The effect of ischemia on nerve conduction. Exp Neurol. 1967 Apr;17(4):403–419. doi: 10.1016/0014-4886(67)90127-6. [DOI] [PubMed] [Google Scholar]
  11. Geller S. A. Extreme exertion rhabdomyolysis: a histopathologic study of 31 cases. Hum Pathol. 1973 Jun;4(2):241–250. doi: 10.1016/s0046-8177(73)80011-5. [DOI] [PubMed] [Google Scholar]
  12. Gudrun B., Andrew G. E., Boysen G., Engel A. G. Effects of microembolization on the skeletal muscle blood flow. A critique of the microvascular occlusion model of Duchenne dystrophy. Acta Neurol Scand. 1975 Jul;52(1):71–80. doi: 10.1111/j.1600-0404.1975.tb02829.x. [DOI] [PubMed] [Google Scholar]
  13. Harriman D. G., Reed R. The incidence of lipid droplets in human skeletal muscle in neuromuscular disorders: a histochemical, electron-microscopic and freeze-etch study. J Pathol. 1972 Jan;106(1):1–24. doi: 10.1002/path.1711060102. [DOI] [PubMed] [Google Scholar]
  14. Harris R. C., Hultman E., Kaijser L., Nordesjö L. O. The effect of circulatory occlusion on isometric exercise capacity and energy metabolism of the quadriceps muscle in man. Scand J Clin Lab Invest. 1975 Jan;35(1):87–95. [PubMed] [Google Scholar]
  15. Haslock D. I., Wright V., Harriman D. G. Neuromuscular disorders in rheumatoid arthritis. A motor-point muscle biopsy study. Q J Med. 1970 Jul;39(155):335–358. [PubMed] [Google Scholar]
  16. Hathaway P. W., Engel W. K., Zellweger H. Experimental myopathy after microarterial embolization; comparison with childhood x-linked pseudohypertrophic muscular dystrophy. Arch Neurol. 1970 Apr;22(4):365–378. doi: 10.1001/archneur.1970.00480220079011. [DOI] [PubMed] [Google Scholar]
  17. Karpati G., Carpenter S., Melmed C., Eisen A. A. Experimental ischemic myopathy. J Neurol Sci. 1974 Sep;23(1):129–161. doi: 10.1016/0022-510x(74)90148-8. [DOI] [PubMed] [Google Scholar]
  18. Matsen F. A., 3rd, Clawson D. K. The deep posterior compartmental syndrome of the leg. J Bone Joint Surg Am. 1975 Jan;57(1):34–39. [PubMed] [Google Scholar]
  19. Mendell J. R., Engel W. K., Derrer E. C. Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions. Science. 1971 Jun 11;172(3988):1143–1145. doi: 10.1126/science.172.3988.1143. [DOI] [PubMed] [Google Scholar]
  20. Neary D., Ochoa J., Gilliatt R. W. Sub-clinical entrapment neuropathy in man. J Neurol Sci. 1975 Mar;24(3):283–298. doi: 10.1016/0022-510x(75)90248-8. [DOI] [PubMed] [Google Scholar]
  21. Ochoa J., Fowler T. J., Gilliatt R. W. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972 Dec;113(Pt 3):433–455. [PMC free article] [PubMed] [Google Scholar]
  22. Penn A. S., Rowland L. P., Fraser D. W. Drugs, coma, and myoglobinuria. Arch Neurol. 1972 Apr;26(4):336–343. doi: 10.1001/archneur.1972.00490100066006. [DOI] [PubMed] [Google Scholar]
  23. Plyley M. J., Groom A. C. Geometrical distribution of capillaries in mammalian striated muscle. Am J Physiol. 1975 May;228(5):1376–1383. doi: 10.1152/ajplegacy.1975.228.5.1376. [DOI] [PubMed] [Google Scholar]
  24. Rob C., May A. G. Neurovascular compression syndromes. Adv Surg. 1975;9:211–234. [PubMed] [Google Scholar]
  25. Rosengart R., Nelson R. J., Emmanoulides G. C. Anterior tibial compartment syndrome in a child: an unusual complication of cardiac catheterization. Pediatrics. 1976 Sep;58(3):456–458. [PubMed] [Google Scholar]
  26. Ruskin A. P., Tanyag-Jocson A., Rogoff J. B. Effect of ischemia on conduction of nerve fibers of varying diameters. Arch Phys Med Rehabil. 1967 Jun;48(6):304–310. [PubMed] [Google Scholar]
  27. Sidey J. D. Weak ankles. A study of common peroneal entrapment neuropathy. Br Med J. 1969 Sep 13;3(5671):623–626. doi: 10.1136/bmj.3.5671.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Warren B. A., Lytton D. G. The effects and morphology of atheroembolism in limb arteries: an experimental study. Pathology. 1976 Jul;8(3):231–245. doi: 10.3109/00313027609059004. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology. Supplement (Royal College of Pathologists). are provided here courtesy of BMJ Publishing Group

RESOURCES