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Journal of Clinical Pathology. Supplement (Royal College of Pathologists) logoLink to Journal of Clinical Pathology. Supplement (Royal College of Pathologists)
. 1977;11:155–169. doi: 10.1136/jcp.s3-11.1.155

Structural abnormalities in neurones.

A W Brown
PMCID: PMC1522210  PMID: 409738

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ames A., 3rd, Wright R. L., Kowada M., Thurston J. M., Majno G. Cerebral ischemia. II. The no-reflow phenomenon. Am J Pathol. 1968 Feb;52(2):437–453. [PMC free article] [PubMed] [Google Scholar]
  2. BECKER N. H., BARRON K. D. The cytochemistry of anoxic and anoxic-ischemic encephalopathy in rats. I. Alterations in neuronal lysosomes identified by acid phosphatase activity. Am J Pathol. 1961 Feb;38:161–175. [PMC free article] [PubMed] [Google Scholar]
  3. BECKER N. H. The cytochemistry of anoxic and anoxioischemic encephalopathy in rats. II. Alterations in neuronal mitochondria indentified by diphosphopyridine and triphosphopyridine nucleotide diaphorases. Am J Pathol. 1961 May;38:587–597. [PMC free article] [PubMed] [Google Scholar]
  4. BRIERLEY J. B. NEUROPATHOLOGICAL FINDINGS IN PATIENTS DYING AFTER OPEN-HEART SURGERY. Thorax. 1963 Dec;18:291–304. doi: 10.1136/thx.18.4.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brierley J. B., Brown A. W., Excell B. J., Meldrum B. S. Brain damage in the rhesus monkey resulting from profound arterial hypotension. I. Its nature, distribution and general physiological correlates. Brain Res. 1969 Mar;13(1):68–100. doi: 10.1016/0006-8993(69)90144-9. [DOI] [PubMed] [Google Scholar]
  6. Brierley J. B., Brown A. W., Meldrum B. S. The nature and time course of the neuronal alterations resulting from oligaemia and hypoglycaemia in the brain of Macaca mulatta. Brain Res. 1971 Feb 5;25(3):483–499. doi: 10.1016/0006-8993(71)90456-2. [DOI] [PubMed] [Google Scholar]
  7. Brierley J. B., Excell B. J. The effects of profound systemic hypotension upon the brain of M. rhesus: physiological and pathological observations. Brain. 1966 Jun;89(2):269–298. doi: 10.1093/brain/89.2.269. [DOI] [PubMed] [Google Scholar]
  8. Brierley J. B., Meldrum B. S., Brown A. W. The threshold and neuropathology of cerebral "anoxic-ischemic" cell change. Arch Neurol. 1973 Dec;29(6):367–374. doi: 10.1001/archneur.1973.00490300029003. [DOI] [PubMed] [Google Scholar]
  9. Brierley J. B., Nicholson A. N. Neuropathological correlates of neurological impairment following prolonged decompression. Aerosp Med. 1969 Feb;40(2):148–152. [PubMed] [Google Scholar]
  10. Brown A. W., Brierley J. B. Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations. J Neurol Sci. 1972 May;16(1):59–84. doi: 10.1016/0022-510x(72)90102-5. [DOI] [PubMed] [Google Scholar]
  11. Brown A. W., Brierley J. B. Evidence for early anoxic-ischaemic cell damage in the rat brain. Experientia. 1966 Aug 15;22(8):546–547. doi: 10.1007/BF01898684. [DOI] [PubMed] [Google Scholar]
  12. Brown A. W., Brierley J. B. The earliest alterations in rat neurones and astrocytes after anoxia-ischaemia. Acta Neuropathol. 1973;23(1):9–22. doi: 10.1007/BF00689000. [DOI] [PubMed] [Google Scholar]
  13. Brown A. W., Brierley J. B. The nature, distribution and earliest stages of anoxic-ischaemic nerve cell damage in the rat brain as defined by the optical microscope. Br J Exp Pathol. 1968 Apr;49(2):87–106. [PMC free article] [PubMed] [Google Scholar]
  14. CAMMERMEYER J. I. An evaluation of the significance of the "dark" neuron. Ergeb Anat Entwicklungsgesch. 1962;36:1–61. [PubMed] [Google Scholar]
  15. CAMMERMEYER J. The post-mortem origin and mechanism of neuronal hyperchromatosis and nuclear pyknosis. Exp Neurol. 1960 Aug;2:379–405. doi: 10.1016/0014-4886(60)90022-4. [DOI] [PubMed] [Google Scholar]
  16. Cammermeyer J. "Ischemic neuronal disease" of Spielmeyer. A reevaluation. Arch Neurol. 1973 Dec;29(6):391–393. doi: 10.1001/archneur.1973.00490300053006. [DOI] [PubMed] [Google Scholar]
  17. Clendenon N. R., Allen N., Komatsu T., Liss L., Gordon W. A., Heimberger K. Biochemical alterations in the anoxic-ischemic lesion of rat brain. Arch Neurol. 1971 Nov;25(5):432–448. doi: 10.1001/archneur.1971.00490050066006. [DOI] [PubMed] [Google Scholar]
  18. Cohen E. B., Pappas G. D. Dark profiles in the apparently-normal central nervous system. A problem in the electron microscopic identification of early anterograde axonal degeneration. J Comp Neurol. 1969 Aug;136(4):375–396. doi: 10.1002/cne.901360403. [DOI] [PubMed] [Google Scholar]
  19. HAGER H., HIRSCHBERGER W., SCHOLZ W. Electron microscopic changes in brain tissue of Syrian hamsters following acute hypoxia. Aerosp Med. 1960 May;31:379–387. [PubMed] [Google Scholar]
  20. HILLS C. P. THE ULTRASTRUCTURE OF ANOXIC-ISCHAEMIC LESIONS IN THE CEREBRAL CORTEX OF THE ADULT RAT BRAIN. Guys Hosp Rep. 1964;113:333–348. [PubMed] [Google Scholar]
  21. KOENIG R. S., KOENIG H. An experimental study of post mortem alterations in neurons of the central nervous system. J Neuropathol Exp Neurol. 1952 Jan;11(1):69–78. doi: 10.1097/00005072-195201000-00008. [DOI] [PubMed] [Google Scholar]
  22. LEVINE S. Anoxic-ischemic encephalopathy in rats. Am J Pathol. 1960 Jan;36:1–17. [PMC free article] [PubMed] [Google Scholar]
  23. Levy D. E., Brierley J. B., Silverman D. G., Plum F. Brief hypoxia-ischemia initially damages cerebral neurons. Arch Neurol. 1975 Jul;32(7):450–456. doi: 10.1001/archneur.1975.00490490054004. [DOI] [PubMed] [Google Scholar]
  24. Little J. R., Kerr F. W., Sundt T. M., Jr The role of lysosomes in production of ischemic nerve cell changes. Arch Neurol. 1974 Jun;30(6):448–455. doi: 10.1001/archneur.1974.00490360024006. [DOI] [PubMed] [Google Scholar]
  25. Little J. R., Sundt T. M., Jr, Kerr F. W. Neuronal alterations in developing cortical infarction. An experimental study in monkeys. J Neurosurg. 1974 Feb;40(2):186–198. doi: 10.3171/jns.1974.40.2.0186. [DOI] [PubMed] [Google Scholar]
  26. Long D. M., Hartmann J. F., French L. A. The ultrastructure of human cerebral edema. J Neuropathol Exp Neurol. 1966 Jul;25(3):373–395. doi: 10.1097/00005072-196607000-00003. [DOI] [PubMed] [Google Scholar]
  27. McGee-Russell S. M., Brown A. W., Brierley J. B. A combined light and electron microscope study of early anoxic-ischaemic cell change in rat brain. Brain Res. 1970 Jun 3;20(2):193–200. doi: 10.1016/0006-8993(70)90288-x. [DOI] [PubMed] [Google Scholar]
  28. Meldrum B. S., Brierley J. B. Prolonged epileptic seizures in primates. Ischemic cell change and its relation to ictal physiological events. Arch Neurol. 1973 Jan;28(1):10–17. doi: 10.1001/archneur.1973.00490190028002. [DOI] [PubMed] [Google Scholar]
  29. Meldrum B. S., Horton R. W., Brierley J. B. Epileptic brain damage in adolescent baboons following seizures induced by allylgycine. Brain. 1974 Jun;97(2):407–418. doi: 10.1093/brain/97.1.407. [DOI] [PubMed] [Google Scholar]
  30. Meldrum B. S., Horton R. W. Physiology of status epilepticus in primates. Arch Neurol. 1973 Jan;28(1):1–9. doi: 10.1001/archneur.1973.00490190019001. [DOI] [PubMed] [Google Scholar]
  31. Meldrum B. S., Vigouroux R. A., Brierley J. B. Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons. Arch Neurol. 1973 Aug;29(2):82–87. doi: 10.1001/archneur.1973.00490260026003. [DOI] [PubMed] [Google Scholar]
  32. Nicholson A. N., Freeland S. A., Brierley J. B. A behavioral and neuropathological study of the sequelae of profound hypoxia. Brain Res. 1970 Sep 16;22(3):327–345. doi: 10.1016/0006-8993(70)90475-0. [DOI] [PubMed] [Google Scholar]
  33. Olsson Y., Hossmann K. A. The effect of intravascular saline perfusion on the sequelae of transient cerebral ischemia. Light and electron microscopial observations. Acta Neuropathol. 1971;17(1):68–79. doi: 10.1007/BF00684742. [DOI] [PubMed] [Google Scholar]
  34. POLANI P. E., MACKEITH R. The sequelae of anoxia; a brief report of two cases recorded cinematographically. Guys Hosp Rep. 1954;103(1):54–58. [PubMed] [Google Scholar]
  35. SPECTOR R. G. Selective changes in dehydrogenase enzymes and pyridine nucleotides in rat brain in anoxic-ischaemic encephalopathy. Br J Exp Pathol. 1963 Jun;44:312–316. [PMC free article] [PubMed] [Google Scholar]
  36. SPECTOR R. G. Water content of the brain in anoxic-ischaemic encephalopathy in adult rats. Br J Exp Pathol. 1961 Dec;42:623–630. [PMC free article] [PubMed] [Google Scholar]
  37. Salford L. G., Plum F., Brierley J. B. Graded hypoxia-oligemia in rat brain. II. Neuropathological alterations and their implications. Arch Neurol. 1973 Oct;29(4):234–238. doi: 10.1001/archneur.1973.00490280046006. [DOI] [PubMed] [Google Scholar]
  38. Shay J., Gonatas N. K. Electron microscopy of cat spinal cord subject to circulatory arrest and deep local hypothermia (15 C). Am J Pathol. 1973 Sep;72(3):369–396. [PMC free article] [PubMed] [Google Scholar]

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