Correction

NEUROSCIENCE. For the article “Development of ¹⁷O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field,” by Xiao-Hong Zhu, Yi Zhang, Run-Xia Tian, Hao Lei, Nanyin Zhang, Xiaoliang Zhang, Hellmut Merkle, Kamil Ugurbil, and Wei Chen, which appeared in number 20, October 1, 2002, of Proc. Natl. Acad. Sci. USA (99, 13194–13199; First Published September 19, 2002; 10.1073/pnas.202471399), the authors note the following correction. After the publication of this article, the authors found a technical error in the setup of parameters used for acquiring the 3D ¹⁷O magnetic resonance spectroscopic (MRS) images reported in this article. This error led to overestimations of the spatial resolution of 3D ¹⁷O MRS images. The claimed voxel sizes of the 3D ¹⁷O MRS images (Figs. 2 and 3) and the cerebral metabolic rate of oxygen (CMRO₂) image (Fig. 6) are 57% smaller than the actual voxel size in each spatial dimension. Therefore, the correct voxel size was 0.10 ml, and the correct field-of-view (FOV) used in the 3D ¹⁷O MRS images was 28 × 28 × 24 mm³. This correction should not significantly affect the major conclusions and methodology presented in this article. However, the correction could reveal that the current sensitivity of ¹⁷O NMR and, alternatively, the spatial resolution of the ¹⁷O MRS image achieved at 9.4 tesla may be potentially limited for determining and imaging CMRO₂ in small brain structures such as the white matter in the rat brain.