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. 1956 Sep;85(3):152–156.

MANAGEMENT OF NEPHROSIS—The Use of Long Continued Hormone Therapy

Carolyn F Piel
PMCID: PMC1531946  PMID: 13356174

Abstract

The course of nephrosis in 36 children was evaluated. Twelve of 24 who received no treatment or short-term courses of steroids died. Eleven of the 24 had been well for six months to five years at the time of this report.

Twelve patients received steroids by schedule over extended periods. One died and eleven had been free of signs and symptoms of nephrosis for four to eighteen months at the time of report. In only two cases was therapy discontinued. It seems evident that these patients are experiencing a better state of well-being. Whether or not the prognosis is being altered for any single patient cannot be determined.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNETT H. L., FORMAN C. W., McNAMARA H., McCORY W. W. The effect of adrenocorticotrophic hormone on children with the nephrotic syndrome. II. Physiologic observations on discrete kidney functions and plasma volume. J Clin Invest. 1951 Feb;30(2):227–235. doi: 10.1172/JCI102437. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. GILBERTSEN A. S., BASHOUR F. Use of malaria therapy in the nephrotic syndrome. J Am Med Assoc. 1956 Jan 7;160(1):25–30. doi: 10.1001/jama.1956.02960360027006. [DOI] [PubMed] [Google Scholar]
  3. HEYMANN W., LUND H. Z. Nephrotic syndrome in rats. Pediatrics. 1951 May;7(5):691–706. [PubMed] [Google Scholar]
  4. HEYMANN W., SPECTOR S., MATTHEWS L. W., SHAPIRO D. J. Treatment of the nephrotic syndrome with corticotropin (ACTH) and cortisone; a four-and-one-half-year survey of results with short-term courses. AMA Am J Dis Child. 1955 Jul;90(1):22–27. doi: 10.1001/archpedi.1955.04030010024004. [DOI] [PubMed] [Google Scholar]
  5. JAMES J., GORDILLO G., METCOFF J. Effects of infusion of hyperoncotic dextran in children with the nephrotic syndrome. J Clin Invest. 1954 Oct;33(10):1346–1357. doi: 10.1172/JCI103011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. KOHN J. L., OBRINSKY W. Lipid nephrosis in children; observations over a period of twenty-six years. AMA Am J Dis Child. 1952 Nov;84(5):587–600. [PubMed] [Google Scholar]
  7. KRAMER B., GOLDMAN H., CASON L. The treatment of the nonedematous nephrotic child with ACTH. J Pediatr. 1952 Dec;41(6):792–803. doi: 10.1016/s0022-3476(52)80299-9. [DOI] [PubMed] [Google Scholar]
  8. LANGE K., SLOBODY L., STRANG R. Prolonged intermittent ACTH and cortisone therapy in the nephrotic syndrome; immunologic gasis and results. Pediatrics. 1955 Feb;15(2):156–168. [PubMed] [Google Scholar]
  9. LAUSON H. D., FORMAN C. W., McNAMARA H., MATTAR G., BARNETT H. L. Effect of corticotropin (ACTH) on glomerular permeability to albumin and on blood antidiuretic hormone concentration in children with the nephrotic syndrome. AMA Am J Dis Child. 1952 Jan;83(1):87–91. [PubMed] [Google Scholar]
  10. LAUSON H. D., FORMAN C. W., McNAMARA H., MATTAR G., BARNETT H. L. The effect of corticotropin (ACTH) on glomerular permeability to albumin in children with the nephrotic syndrome. J Clin Invest. 1954 Apr;33(4):657–664. doi: 10.1172/JCI102936. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. LUETSCHER J. A., Jr, DEMING Q. B. Treatment of nephrosis with cortisone. J Clin Invest. 1950 Dec;29(12):1576–1587. doi: 10.1172/JCI102399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. LUETSCHER J. A., Jr Problems of electrolyte and water balance in nephrotic syndrome. AMA Arch Intern Med. 1955 Mar;95(3):380–384. doi: 10.1001/archinte.1955.00250090018004. [DOI] [PubMed] [Google Scholar]
  13. Luetscher J. A., Hall A. D., Kremer V. L. TREATMENT OF NEPHROSIS WITH CONCENTRATED HUMAN SERUM ALBUMIN. I. EFFECTS ON THE PROTEINS OF BODY FLUIDS. J Clin Invest. 1949 Jul;28(4):700–712. doi: 10.1172/JCI102121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. METCOFF J., RANCE C. P., KELSEY W. M., NAKASONE N., JANEWAY C. A. Adrenocorticotrophic hormone (ACTH) therapy of the nephrotic syndrome in children. Pediatrics. 1952 Nov;10(5):543–566. [PubMed] [Google Scholar]
  15. OLIVE J. T., Jr, MILLS S. D., LUNDY J. S. Dextran for nephrotic edema; clinical experience. Proc Staff Meet Mayo Clin. 1953 Apr 8;28(7):199–204. [PubMed] [Google Scholar]
  16. PHILIPS I., CALVIN J. K., KAGAN B. M. Nephrotic syndrome in children; observations on the clinical course and the influence of sulfonamide and antibiotic therapy. AMA Am J Dis Child. 1953 Apr;85(4):451–461. doi: 10.1001/archpedi.1953.02050070465004. [DOI] [PubMed] [Google Scholar]
  17. RANCE C. P., CHUTE A. L. Treatment of the nephrotic syndrome in children. Can Med Assoc J. 1955 Dec 15;73(12):959–964. [PMC free article] [PubMed] [Google Scholar]
  18. RAPOPORT M., McCRORY W. W., BARBERO G., BARNETT H. L., FORMAN C. W. Effect of corticotropin (ACTH) on children with the nephrotic syndrome. J Am Med Assoc. 1951 Nov 17;147(12):1101–1106. doi: 10.1001/jama.1951.03670290009004. [DOI] [PubMed] [Google Scholar]
  19. RILEY C. M. Corticotropin and cortisone in management of the nephrotic syndrome in children. J Am Med Assoc. 1952 Nov 29;150(13):1288–1291. doi: 10.1001/jama.1952.03680130020005. [DOI] [PubMed] [Google Scholar]
  20. STICKLER G. B., BURKE E. C., McKENZIE B. F. Electrophoretic studies of the nephrotic syndrome in children: preliminary report. Proc Staff Meet Mayo Clin. 1954 Oct 13;29(21):555–561. [PubMed] [Google Scholar]

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