Abstract
Tubercle bacilli are spread by the blood stream to the kidney in miliary fashion from the primary pulmonary lesion. Activation, followed by arrest, may delay development of the disease in the kidney for many years or “healing” may occur. Renal ulcerative lesions are the most frequent source of infection of other genitourinary organs.
In pyelograms there is no particular characteristic of lesions of tuberculosis. Cellular elements in the urine of a patient with tuberculosis of other organs should lead to urine culture and guinea pig inoculation for mycobacterium tuberculosis.
Treatment with streptomycin, isonicotinic acid and/or para-aminosalicylic acid should be started as soon as genitourinary tuberculosis is proved. Patients with advanced lesions usually receive great benefit from these medications; even though organisms may not be eliminated they are definitely diminished in activity. Excision of diseased organs or tissue may be necessary in a few cases.
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Selected References
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- BARCLAY W. R., EBERT R. H., LE ROY G. V., MANTHEI R. W., ROTH L. J. Distribution and excretion of radioactive isoniazid in tuberculous patients. J Am Med Assoc. 1953 Apr 18;151(16):1384–1388. [PubMed] [Google Scholar]
- CORPER H. J. Analysis of the value of chemotherapeutic agents in treatment of tuberculosis. J Am Med Assoc. 1953 Apr 25;151(17):1475–1478. [PubMed] [Google Scholar]
- HOWSON C. R., ROUFF E. A. Correlation of genito-urinary and general tuberculosis. Calif Med. 1952 Mar;76(3):143–146. [PMC free article] [PubMed] [Google Scholar]
- LATTIMER J. K., AMBERSON J. B., BRAHAM S. The treatment of genito-urinary tuberculosis with streptomycin alone. J Urol. 1949 Dec;62(6):875-91, illust. doi: 10.1016/S0022-5347(17)69016-5. [DOI] [PubMed] [Google Scholar]
- LATTIMER J. K. Caution necessary in the treatment of renal tuberculosis with isoniazid. J Am Med Assoc. 1952 Nov 8;150(10):981–983. doi: 10.1001/jama.1952.03680100023007. [DOI] [PubMed] [Google Scholar]
- MEDLAR E. M. Pathogenetic concepts of tuberculosis. Am J Med. 1950 Nov;9(5):611–622. doi: 10.1016/0002-9343(50)90211-7. [DOI] [PubMed] [Google Scholar]
- NESBIT R. M., THIRLBY R. L. Results of streptomycin therapy in urinary tuberculosis: a four year review. J Urol. 1952 Jul;68(1):394–398. doi: 10.1016/S0022-5347(17)68212-0. [DOI] [PubMed] [Google Scholar]
- SELIKOFF I. J., ROBITZEK E. H., ORNSTEIN G. G. Treatment of pulmonary tuberculosis with hydrazide derivatives of isonicotinic acid. J Am Med Assoc. 1952 Nov 8;150(10):973–980. doi: 10.1001/jama.1952.03680100015006. [DOI] [PubMed] [Google Scholar]