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. 1998 Jun;106(Suppl 3):893–908. doi: 10.1289/ehp.98106893

Pesticides and childhood cancer.

S H Zahm 1, M H Ward 1
PMCID: PMC1533072  PMID: 9646054

Abstract

Children are exposed to potentially carcinogenic pesticides from use in homes, schools, other buildings, lawns and gardens, through food and contaminated drinking water, from agricultural application drift, overspray, or off-gassing, and from carry-home exposure of parents occupationally exposed to pesticides. Parental exposure during the child's gestation or even preconception may also be important. Malignancies linked to pesticides in case reports or case-control studies include leukemia, neuroblastoma, Wilms' tumor, soft-tissue sarcoma, Ewing's sarcoma, non-Hodgkin's lymphoma, and cancers of the brain, colorectum, and testes. Although these studies have been limited by nonspecific pesticide exposure information, small numbers of exposed subjects, and the potential for case-response bias, it is noteworthy that many of the reported increased risks are of greater magnitude than those observed in studies of pesticide-exposed adults, suggesting that children may be particularly sensitive to the carcinogenic effects of pesticides. Future research should include improved exposure assessment, evaluation of risk by age at exposure, and investigation of possible genetic-environment interactions. There is potential to prevent at least some childhood cancer by reducing or eliminating pesticide exposure.

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Selected References

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  1. Buckley J. D., Robison L. L., Swotinsky R., Garabrant D. H., LeBeau M., Manchester P., Nesbit M. E., Odom L., Peters J. M., Woods W. G. Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the Childrens Cancer Study Group. Cancer Res. 1989 Jul 15;49(14):4030–4037. [PubMed] [Google Scholar]
  2. Bunin G. R., Buckley J. D., Boesel C. P., Rorke L. B., Meadows A. T. Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children's Cancer Group. Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):197–204. [PubMed] [Google Scholar]
  3. Bunin G. R., Petrakova A., Meadows A. T., Emanuel B. S., Buckley J. D., Woods W. G., Hammond G. D. Occupations of parents of children with retinoblastoma: a report from the Children's Cancer Study Group. Cancer Res. 1990 Nov 15;50(22):7129–7133. [PubMed] [Google Scholar]
  4. Bunin G. R., Ward E., Kramer S., Rhee C. A., Meadows A. T. Neuroblastoma and parental occupation. Am J Epidemiol. 1990 May;131(5):776–780. doi: 10.1093/oxfordjournals.aje.a115568. [DOI] [PubMed] [Google Scholar]
  5. Caldwell G. G., Cannon S. B., Pratt C. B., Arthur R. D. Serum pesticide levels in patients with childhood colorectal carcinoma. Cancer. 1981 Aug 1;48(3):774–778. doi: 10.1002/1097-0142(19810801)48:3<774::aid-cncr2820480319>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  6. Chadduck W. M., Gollin S. M., Gray B. A., Norris J. S., Araoz C. A., Tryka A. F. Gliosarcoma with chromosome abnormalities in a neonate exposed to heptachlor. Neurosurgery. 1987 Oct;21(4):557–559. doi: 10.1227/00006123-198710000-00021. [DOI] [PubMed] [Google Scholar]
  7. Cordier S., Iglesias M. J., Le Goaster C., Guyot M. M., Mandereau L., Hemon D. Incidence and risk factors for childhood brain tumors in the Ile de France. Int J Cancer. 1994 Dec 15;59(6):776–782. doi: 10.1002/ijc.2910590612. [DOI] [PubMed] [Google Scholar]
  8. Davies J. E., Edmundson W. F., Raffonelli A. The role of house dust in human DDT pollution. Am J Public Health. 1975 Jan;65(1):53–57. doi: 10.2105/ajph.65.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Davis J. R., Brownson R. C., Garcia R., Bentz B. J., Turner A. Family pesticide use and childhood brain cancer. Arch Environ Contam Toxicol. 1993 Jan;24(1):87–92. doi: 10.1007/BF01061094. [DOI] [PubMed] [Google Scholar]
  10. Deschamps M., Band P. Study of a cluster of childhood leukemia. Health Rep. 1993;5(1):81–85. [PubMed] [Google Scholar]
  11. Fabia J., Thuy T. D. Occupation of father at time of birth of children dying of malignant diseases. Br J Prev Soc Med. 1974 May;28(2):98–100. doi: 10.1136/jech.28.2.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gardner M. J., Snee M. P., Hall A. J., Powell C. A., Downes S., Terrell J. D. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. BMJ. 1990 Feb 17;300(6722):423–429. doi: 10.1136/bmj.300.6722.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Gladen B. C., Rogan W. J. DDE and shortened duration of lactation in a northern Mexican town. Am J Public Health. 1995 Apr;85(4):504–508. doi: 10.2105/ajph.85.4.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Gold E. B., Diener M. D., Szklo M. Parental occupations and cancer in children--a case-control study and review of the methodologic issues. J Occup Med. 1982 Aug;24(8):578–584. [PubMed] [Google Scholar]
  15. Gold E., Gordis L., Tonascia J., Szklo M. Risk factors for brain tumors in children. Am J Epidemiol. 1979 Mar;109(3):309–319. doi: 10.1093/oxfordjournals.aje.a112684. [DOI] [PubMed] [Google Scholar]
  16. Grossman J. What's hiding under the sink: dangers of household pesticides. Environ Health Perspect. 1995 Jun;103(6):550–554. doi: 10.1289/ehp.95103550. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Grufferman S. Methodologic approaches to studying environmental factors in childhood cancer. Environ Health Perspect. 1998 Jun;106 (Suppl 3):881–886. doi: 10.1289/ehp.98106881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Gurunathan S., Robson M., Freeman N., Buckley B., Roy A., Meyer R., Bukowski J., Lioy P. J. Accumulation of chlorpyrifos on residential surfaces and toys accessible to children. Environ Health Perspect. 1998 Jan;106(1):9–16. doi: 10.1289/ehp.981069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Harris S. A., Solomon K. R., Stephenson G. R. Exposure of homeowners and bystanders to 2,4-dichlorophenoxyacetic acid (2,4-D). J Environ Sci Health B. 1992 Feb;27(1):23–38. doi: 10.1080/03601239209372765. [DOI] [PubMed] [Google Scholar]
  20. Hayes H. M., Tarone R. E., Cantor K. P., Jessen C. R., McCurnin D. M., Richardson R. C. Case-control study of canine malignant lymphoma: positive association with dog owner's use of 2,4-dichlorophenoxyacetic acid herbicides. J Natl Cancer Inst. 1991 Sep 4;83(17):1226–1231. doi: 10.1093/jnci/83.17.1226. [DOI] [PubMed] [Google Scholar]
  21. Hemminki K., Saloniemi I., Salonen T., Partanen T., Vainio H. Childhood cancer and parental occupation in Finland. J Epidemiol Community Health. 1981 Mar;35(1):11–15. doi: 10.1136/jech.35.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hill R. H., Jr, To T., Holler J. S., Fast D. M., Smith S. J., Needham L. L., Binder S. Residues of chlorinated phenols and phenoxy acid herbicides in the urine of Arkansas children. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):469–474. doi: 10.1007/BF01055011. [DOI] [PubMed] [Google Scholar]
  23. Holly E. A., Aston D. A., Ahn D. K., Kristiansen J. J. Ewing's bone sarcoma, paternal occupational exposure, and other factors. Am J Epidemiol. 1992 Jan 15;135(2):122–129. doi: 10.1093/oxfordjournals.aje.a116265. [DOI] [PubMed] [Google Scholar]
  24. Holman C. D., Reynolds P. M., Byrne M. J., Trotter J. M., Armstrong B. K. Possible infectious etiology of six cases of Ewing's sarcoma in Western Australia. Cancer. 1983 Nov 15;52(10):1974–1976. doi: 10.1002/1097-0142(19831115)52:10<1974::aid-cncr2820521033>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
  25. Howe G. R., Burch J. D., Chiarelli A. M., Risch H. A., Choi B. C. An exploratory case-control study of brain tumors in children. Cancer Res. 1989 Aug 1;49(15):4349–4352. [PubMed] [Google Scholar]
  26. Infante-Rivard C., Mur P., Armstrong B., Alvarez-Dardet C., Bolumar F. Acute lymphoblastic leukaemia among Spanish children and mothers' occupation: a case-control study. J Epidemiol Community Health. 1991 Mar;45(1):11–15. doi: 10.1136/jech.45.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Infante P. F., Epstein S. S., Newton W. A., Jr Blood dyscrasias and childhood tumors and exposure to chlordane and heptachlor. Scand J Work Environ Health. 1978 Jun;4(2):137–150. doi: 10.5271/sjweh.2718. [DOI] [PubMed] [Google Scholar]
  28. Infante P. F., Newton W. A., Jr Letter: Prenatal chlordane exposure and neuroblastoma. N Engl J Med. 1975 Aug 7;293(6):308–308. doi: 10.1056/nejm197508072930625. [DOI] [PubMed] [Google Scholar]
  29. Kantor A. F., Curnen M. G., Meigs J. W., Flannery J. T. Occupations of fathers of patients with Wilms's tumour. J Epidemiol Community Health. 1979 Dec;33(4):253–256. doi: 10.1136/jech.33.4.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Kloos H. 1,2 Dibromo-3-chloropropane (DBCP) and ethylene dibromide (EDB) in well water in the Fresno/Clovis metropolitan area, California. Arch Environ Health. 1996 Jul-Aug;51(4):291–299. doi: 10.1080/00039896.1996.9936028. [DOI] [PubMed] [Google Scholar]
  31. Kristensen P., Andersen A., Irgens L. M., Bye A. S., Sundheim L. Cancer in offspring of parents engaged in agricultural activities in Norway: incidence and risk factors in the farm environment. Int J Cancer. 1996 Jan 3;65(1):39–50. doi: 10.1002/(SICI)1097-0215(19960103)65:1<39::AID-IJC8>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  32. Kuijten R. R., Bunin G. R., Nass C. C., Meadows A. T. Parental occupation and childhood astrocytoma: results of a case-control study. Cancer Res. 1992 Feb 15;52(4):782–786. [PubMed] [Google Scholar]
  33. Laval G., Tuyns A. J. Environmental factors in childhood leukaemia. Br J Ind Med. 1988 Dec;45(12):843–844. doi: 10.1136/oem.45.12.843. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Leiss J. K., Savitz D. A. Home pesticide use and childhood cancer: a case-control study. Am J Public Health. 1995 Feb;85(2):249–252. doi: 10.2105/ajph.85.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Lowengart R. A., Peters J. M., Cicioni C., Buckley J., Bernstein L., Preston-Martin S., Rappaport E. Childhood leukemia and parents' occupational and home exposures. J Natl Cancer Inst. 1987 Jul;79(1):39–46. [PubMed] [Google Scholar]
  36. Magnani C., Pastore G., Luzzatto L., Carli M., Lubrano P., Terracini B. Risk factors for soft tissue sarcomas in childhood: a case-control study. Tumori. 1989 Aug 31;75(4):396–400. doi: 10.1177/030089168907500418. [DOI] [PubMed] [Google Scholar]
  37. Magnani C., Pastore G., Luzzatto L., Terracini B. Parental occupation and other environmental factors in the etiology of leukemias and non-Hodgkin's lymphomas in childhood: a case-control study. Tumori. 1990 Oct 31;76(5):413–419. doi: 10.1177/030089169007600501. [DOI] [PubMed] [Google Scholar]
  38. McCredie M., Maisonneuve P., Boyle P. Antenatal risk factors for malignant brain tumours in New South Wales children. Int J Cancer. 1994 Jan 2;56(1):6–10. doi: 10.1002/ijc.2910560103. [DOI] [PubMed] [Google Scholar]
  39. McCredie M., Maisonneuve P., Boyle P. Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children. Int J Cancer. 1994 Jan 2;56(1):11–15. doi: 10.1002/ijc.2910560104. [DOI] [PubMed] [Google Scholar]
  40. Meinert R., Kaatsch P., Kaletsch U., Krummenauer F., Miesner A., Michaelis J. Childhood leukaemia and exposure to pesticides: results of a case-control study in northern Germany. Eur J Cancer. 1996 Oct;32A(11):1943–1948. doi: 10.1016/0959-8049(96)00231-6. [DOI] [PubMed] [Google Scholar]
  41. Mills P. K., Newell G. R., Johnson D. E. Testicular cancer associated with employment in agriculture and oil and natural gas extraction. Lancet. 1984 Jan 28;1(8370):207–210. doi: 10.1016/s0140-6736(84)92125-1. [DOI] [PubMed] [Google Scholar]
  42. Moses M., Johnson E. S., Anger W. K., Burse V. W., Horstman S. W., Jackson R. J., Lewis R. G., Maddy K. T., McConnell R., Meggs W. J. Environmental equity and pesticide exposure. Toxicol Ind Health. 1993 Sep-Oct;9(5):913–959. doi: 10.1177/074823379300900512. [DOI] [PubMed] [Google Scholar]
  43. Moses M. Pesticide-related health problems and farmworkers. AAOHN J. 1989 Mar;37(3):115–130. [PubMed] [Google Scholar]
  44. Mulder Y. M., Drijver M., Kreis I. A. Case-control study on the association between a cluster of childhood haematopoietic malignancies and local environmental factors in Aalsmeer, The Netherlands. J Epidemiol Community Health. 1994 Apr;48(2):161–165. doi: 10.1136/jech.48.2.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Murphy R. S., Kutz F. W., Strassman S. C. Selected pesticide residues or metabolites in blood and urine specimens from a general population survey. Environ Health Perspect. 1983 Feb;48:81–86. doi: 10.1289/ehp.834881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Olshan A. F., Breslow N. E., Falletta J. M., Grufferman S., Pendergrass T., Robison L. L., Waskerwitz M., Woods W. G., Vietti T. J., Hammond G. D. Risk factors for Wilms tumor. Report from the National Wilms Tumor Study. Cancer. 1993 Aug 1;72(3):938–944. doi: 10.1002/1097-0142(19930801)72:3<938::aid-cncr2820720345>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  47. Pogoda J. M., Preston-Martin S. Household pesticides and risk of pediatric brain tumors. Environ Health Perspect. 1997 Nov;105(11):1214–1220. doi: 10.1289/ehp.971051214. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Pratt C. B., Rivera G., Shanks E., Johnson W. W., Howarth C., Terrell W., Kumar A. P. Colorectal carcinoma in adolescents implications regarding etiology. Cancer. 1977 Nov;40(5 Suppl):2464–2472. doi: 10.1002/1097-0142(197711)40:5+<2464::aid-cncr2820400912>3.0.co;2-d. [DOI] [PubMed] [Google Scholar]
  49. Reeves J. D., Driggers D. A., Kiley V. A. Household insecticide associated aplastic anaemia and acute leukaemia in children. Lancet. 1981 Aug 8;2(8241):300–301. doi: 10.1016/s0140-6736(81)90540-7. [DOI] [PubMed] [Google Scholar]
  50. Reeves J. D. Household insecticide-associated blood dyscrasias in children. Am J Pediatr Hematol Oncol. 1982 Winter;4(4):438–439. [PubMed] [Google Scholar]
  51. Reynolds P. M., Reif J. S., Ramsdell H. S., Tessari J. D. Canine exposure to herbicide-treated lawns and urinary excretion of 2,4-dichlorophenoxyacetic acid. Cancer Epidemiol Biomarkers Prev. 1994 Apr-May;3(3):233–237. [PubMed] [Google Scholar]
  52. Rogan W. J., Gladen B. C. Study of human lactation for effects of environmental contaminants: the North Carolina Breast Milk and Formula Project and some other ideas. Environ Health Perspect. 1985 May;60:215–221. doi: 10.1289/ehp.8560215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Roman E., Watson A., Beral V., Buckle S., Bull D., Baker K., Ryder H., Barton C. Case-control study of leukaemia and non-Hodgkin's lymphoma among children aged 0-4 years living in west Berkshire and north Hampshire health districts. BMJ. 1993 Mar 6;306(6878):615–621. doi: 10.1136/bmj.306.6878.615. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Savage E. P., Keefe T. J., Wheeler H. W., Mounce L., Helwic L., Applehans F., Goes E., Goes T., Mihlan G., Rench J. Household pesticide usage in the United States. Arch Environ Health. 1981 Nov-Dec;36(6):304–309. doi: 10.1080/00039896.1981.10667642. [DOI] [PubMed] [Google Scholar]
  55. Scheele J., Teufel M., Niessen K. H. Chlorinated hydrocarbons in the bone marrow of children: studies on their association with leukaemia. Eur J Pediatr. 1992 Nov;151(11):802–805. doi: 10.1007/BF01957928. [DOI] [PubMed] [Google Scholar]
  56. Schwartzbaum J. A., George S. L., Pratt C. B., Davis B. An exploratory study of environmental and medical factors potentially related to childhood cancer. Med Pediatr Oncol. 1991;19(2):115–121. doi: 10.1002/mpo.2950190209. [DOI] [PubMed] [Google Scholar]
  57. Sharpe C. R., Franco E. L., de Camargo B., Lopes L. F., Barreto J. H., Johnsson R. R., Mauad M. A. Parental exposures to pesticides and risk of Wilms' tumor in Brazil. Am J Epidemiol. 1995 Feb 1;141(3):210–217. doi: 10.1093/oxfordjournals.aje.a117422. [DOI] [PubMed] [Google Scholar]
  58. Shu X. O., Gao Y. T., Brinton L. A., Linet M. S., Tu J. T., Zheng W., Fraumeni J. F., Jr A population-based case-control study of childhood leukemia in Shanghai. Cancer. 1988 Aug 1;62(3):635–644. doi: 10.1002/1097-0142(19880801)62:3<635::aid-cncr2820620332>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
  59. Shu X. O., Nesbit M. E., Buckley J. D., Krailo M. D., Robinson L. L. An exploratory analysis of risk factors for childhood malignant germ-cell tumors: report from the Childrens Cancer Group (Canada, United States). Cancer Causes Control. 1995 May;6(3):187–198. doi: 10.1007/BF00051790. [DOI] [PubMed] [Google Scholar]
  60. Simcox N. J., Fenske R. A., Wolz S. A., Lee I. C., Kalman D. A. Pesticides in household dust and soil: exposure pathways for children of agricultural families. Environ Health Perspect. 1995 Dec;103(12):1126–1134. doi: 10.1289/ehp.951031126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Spitz M. R., Johnson C. C. Neuroblastoma and paternal occupation. A case-control analysis. Am J Epidemiol. 1985 Jun;121(6):924–929. doi: 10.1093/oxfordjournals.aje.a114062. [DOI] [PubMed] [Google Scholar]
  62. Starr H. G., Jr, Aldrich F. D., MacDougall W. D., 3rd, Mounce L. M. Contribution of household dust to the human exposure to pesticides. Pestic Monit J. 1974 Dec;8(3):209–212. [PubMed] [Google Scholar]
  63. Whitemore R. W., Immerman F. W., Camann D. E., Bond A. E., Lewis R. G., Schaum J. L. Non-occupational exposures to pesticides for residents of two U.S. cities. Arch Environ Contam Toxicol. 1994 Jan;26(1):47–59. doi: 10.1007/BF00212793. [DOI] [PubMed] [Google Scholar]
  64. Wilkins J. R., 3rd, Hundley V. D. Paternal occupational exposure to electromagnetic fields and neuroblastoma in offspring. Am J Epidemiol. 1990 Jun;131(6):995–1008. doi: 10.1093/oxfordjournals.aje.a115620. [DOI] [PubMed] [Google Scholar]
  65. Wilkins J. R., 3rd, Koutras R. A. Paternal occupation and brain cancer in offspring: a mortality-based case-control study. Am J Ind Med. 1988;14(3):299–318. doi: 10.1002/ajim.4700140308. [DOI] [PubMed] [Google Scholar]
  66. Wilkins J. R., 3rd, Sinks T. H., Jr Occupational exposures among fathers of children with Wilms' tumor. J Occup Med. 1984 Jun;26(6):427–435. doi: 10.1097/00043764-198406000-00015. [DOI] [PubMed] [Google Scholar]
  67. Wilkins J. R., 3rd, Sinks T. Parental occupation and intracranial neoplasms of childhood: results of a case-control interview study. Am J Epidemiol. 1990 Aug;132(2):275–292. doi: 10.1093/oxfordjournals.aje.a115657. [DOI] [PubMed] [Google Scholar]
  68. Winn D. M., Li F. P., Robison L. L., Mulvihill J. J., Daigle A. E., Fraumeni J. F., Jr A case-control study of the etiology of Ewing's sarcoma. Cancer Epidemiol Biomarkers Prev. 1992 Nov-Dec;1(7):525–532. [PubMed] [Google Scholar]
  69. Zahm S. H., Blair A. Cancer among migrant and seasonal farmworkers: an epidemiologic review and research agenda. Am J Ind Med. 1993 Dec;24(6):753–766. doi: 10.1002/ajim.4700240612. [DOI] [PubMed] [Google Scholar]
  70. Zahm S. H., Blair A. Cancer feasibility studies among migrant farmworkers. The Farmworker Epidemiology Research Group. Am J Ind Med. 1997 Sep;32(3):301–302. doi: 10.1002/(sici)1097-0274(199709)32:3<301::aid-ajim17>3.0.co;2-z. [DOI] [PubMed] [Google Scholar]
  71. Zahm S. H., Weisenburger D. D., Saal R. C., Vaught J. B., Babbitt P. A., Blair A. The role of agricultural pesticide use in the development of non-Hodgkin's lymphoma in women. Arch Environ Health. 1993 Sep-Oct;48(5):353–358. doi: 10.1080/00039896.1993.9936725. [DOI] [PubMed] [Google Scholar]
  72. Zamora P., García de Paredes M. L., González Barón M., Diaz M. A., Escobar Y., Ordóez A., López Barea F., González J. M. Ewing's tumor in brothers. An unusual observation. Am J Clin Oncol. 1986 Aug;9(4):358–360. doi: 10.1097/00000421-198608000-00017. [DOI] [PubMed] [Google Scholar]
  73. van Steensel-Moll H. A., Valkenburg H. A., van Zanen G. E. Childhood leukemia and parental occupation. A register-based case-control study. Am J Epidemiol. 1985 Feb;121(2):216–224. doi: 10.1093/oxfordjournals.aje.a113992. [DOI] [PubMed] [Google Scholar]

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