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. 1998 Oct;106(10):623–627. doi: 10.1289/ehp.106-1533173

Human exposure assessment and the National Toxicology Program.

G W Lucier 1, A Schecter 1
PMCID: PMC1533173  PMID: 9755136

Abstract

The National Institute of Environmental Health Sciences/National Toxicology Program (NIEHS/NTP) is developing a new interagency initiative in exposure assessment. This initiative involves the NIEHS, the Centers for Disease Control and Prevention through its National Center for Environmental Health, the National Institute for Occupational Safety and Health, the EPA, and other participating institutes and agencies of the NTP. This initiative will benefit public health and priority setting in a number of ways. First, as discussed above, it will strengthen the scientific foundation for risk assessments by the development of more credible exposure/response relationships in people by improving cross-species extrapolation, the development of biologically based dose-response models, and the identification of sensitive subpopulations and for "margin of exposure" based estimates of risk. Second, it will provide the kind of information necessary for deciding which chemicals should be studied with the limited resources available for toxicological testing. For example, there are 85,000 chemicals in commerce today, and the NTP can only provide toxicological evaluations on 10-20 per year. Third, we would use the information obtained from the exposure initiative to focus our research on mixtures that are actually present in people's bodies. Fourth, we would obtain information on the kinds and amount of chemicals in children and other potentially sensitive subpopulations. Determinations of whether additional safety factors need to be applied to children must rest, in part, upon comparative exposure analyses between children and adults. Fifth, this initiative, taken together with the environmental genome initiative, will provide the science base essential for meaningful studies on gene/environment interactions, particularly for strengthening the evaluation of epidemiology studies. Sixth, efficacy of public health policies aimed at reducing human exposure to chemical agents could be evaluated in a more meaningful way if body burden data were available over time, including remediation around Superfund sites and efforts to achieve environmental justice. The exposure assessment initiative is needed to address public health needs. It is feasible because of recent advances in analytical technology and molecular biology, and it is an example of how different agencies can work together to better fulfill their respective missions.

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Selected References

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  1. Bucher J. R. Update on national toxicology program (NTP) assays with genetically altered or "transgenic" mice. Environ Health Perspect. 1998 Oct;106(10):619–621. doi: 10.1289/ehp.98106619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Colborn T., vom Saal F. S., Soto A. M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993 Oct;101(5):378–384. doi: 10.1289/ehp.93101378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Guengerich F. P. The Environmental Genome Project: functional analysis of polymorphisms. Environ Health Perspect. 1998 Jul;106(7):365–368. doi: 10.1289/ehp.98106365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Kaiser J. Environment institute lays plans for gene hunt. Science. 1997 Oct 24;278(5338):569–570. doi: 10.1126/science.278.5338.569. [DOI] [PubMed] [Google Scholar]
  5. Lucier G. W. Risk assessment: good science for good decisions. Environ Health Perspect. 1993 Oct;101(5):366–366. doi: 10.1289/ehp.93101366. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Needham L. L., Hill R. H., Jr, Ashley D. L., Pirkle J. L., Sampson E. J. The priority toxicant reference range study: interim report. Environ Health Perspect. 1995 Apr;103 (Suppl 3):89–94. doi: 10.1289/ehp.95103s389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pirkle J. L., Brody D. J., Gunter E. W., Kramer R. A., Paschal D. C., Flegal K. M., Matte T. D. The decline in blood lead levels in the United States. The National Health and Nutrition Examination Surveys (NHANES) JAMA. 1994 Jul 27;272(4):284–291. [PubMed] [Google Scholar]
  8. Popp W., Müller G., Baltes-Schmitz B., Wehner B., Vahrenholz C., Schmieding W., Benninghoff M., Norpoth K. Concentrations of tetrachloroethene in blood and trichloroacetic acid in urine in workers and neighbours of dry-cleaning shops. Int Arch Occup Environ Health. 1992;63(6):393–395. doi: 10.1007/BF00386934. [DOI] [PubMed] [Google Scholar]
  9. Robinson P. E., Mack G. A., Remmers J., Levy R., Mohadjer L. Trends of PCB, hexachlorobenzene, and beta-benzene hexachloride levels in the adipose tissue of the U.S. population. Environ Res. 1990 Dec;53(2):175–192. doi: 10.1016/s0013-9351(05)80118-5. [DOI] [PubMed] [Google Scholar]
  10. Schreiber J. S., House S., Prohonic E., Smead G., Hudson C., Styk M., Lauber J. An investigation of indoor air contamination in residences above dry cleaners. Risk Anal. 1993 Jun;13(3):335–344. doi: 10.1111/j.1539-6924.1993.tb01085.x. [DOI] [PubMed] [Google Scholar]
  11. Sexton K., Kleffman D. E., Callahan M. A. An introduction to the National Human Exposure Assessment Survey (NHEXAS) and related phase I field studies. J Expo Anal Environ Epidemiol. 1995 Jul-Sep;5(3):229–232. [PubMed] [Google Scholar]
  12. Wiener J. O. Risk assessment and cost-benefit analyses: in the public interest? Environ Health Perspect. 1993 Oct;101(5):408–409. doi: 10.1289/ehp.93101408. [DOI] [PMC free article] [PubMed] [Google Scholar]

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