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. 1998 Dec;106(12):793–796. doi: 10.1289/ehp.98106793

Cryptorchidism and hypospadias in sons of gardeners and farmers.

I S Weidner 1, H Møller 1, T K Jensen 1, N E Skakkebaek 1
PMCID: PMC1533236  PMID: 9831539

Abstract

Cryptorchidism and hypospadias have been related to prenatal estrogen exposure in animal models. Some chemicals used in farming and gardening have been shown to possess estrogenic and other hormone-disrupting effects. Earlier studies have indicated increased risks of urogenital malformations in the sons of pesticide appliers. In the present study, parental occupation in the farming and gardening industry among 6,177 cases of cryptorchidism, 1,345 cases of hypospadias, and 23,273 controls, born live from 1983 to 1992 in Denmark, was investigated in a register-based case-control study. A significantly increased risk of cryptorchidism but not hypospadias was found in sons of women working in gardening (adjusted odds ratio = 1.67; 95% confidence interval, 1.14-2.47). The risks were not increased in sons of men working in farming or gardening. The increased risk of cryptorchidism among sons of female gardeners could suggest an association with prenatal exposure to occupationally related chemicals.

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Selected References

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  1. Adami H. O., Bergström R., Möhner M., Zatoński W., Storm H., Ekbom A., Tretli S., Teppo L., Ziegler H., Rahu M. Testicular cancer in nine northern European countries. Int J Cancer. 1994 Oct 1;59(1):33–38. doi: 10.1002/ijc.2910590108. [DOI] [PubMed] [Google Scholar]
  2. Auger J., Kunstmann J. M., Czyglik F., Jouannet P. Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med. 1995 Feb 2;332(5):281–285. doi: 10.1056/NEJM199502023320501. [DOI] [PubMed] [Google Scholar]
  3. Bostofte E., Serup J., Rebbe H. Has the fertility of Danish men declined through the years in terms of semen quality? A comparison of semen qualities between 1952 and 1972. Int J Fertil. 1983;28(2):91–95. [PubMed] [Google Scholar]
  4. Carlsen E., Giwercman A., Keiding N., Skakkebaek N. E. Evidence for decreasing quality of semen during past 50 years. BMJ. 1992 Sep 12;305(6854):609–613. doi: 10.1136/bmj.305.6854.609. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Czeizel A., Tóth J., Czvenits E. Increased birth prevalence of isolated hypospadias in Hungary. Acta Paediatr Hung. 1986;27(4):329–337. [PubMed] [Google Scholar]
  6. Fisch H., Goluboff E. T. Geographic variations in sperm counts: a potential cause of bias in studies of semen quality. Fertil Steril. 1996 May;65(5):1044–1046. doi: 10.1016/s0015-0282(16)58284-3. [DOI] [PubMed] [Google Scholar]
  7. Forman D., Møller H. Testicular cancer. Cancer Surv. 1994;19-20:323–341. [PubMed] [Google Scholar]
  8. García-Rodríguez J., García-Martín M., Nogueras-Ocaña M., de Dios Luna-del-Castillo J., Espigares García M., Olea N., Lardelli-Claret P. Exposure to pesticides and cryptorchidism: geographical evidence of a possible association. Environ Health Perspect. 1996 Oct;104(10):1090–1095. doi: 10.1289/ehp.104-1469503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garry V. F., Schreinemachers D., Harkins M. E., Griffith J. Pesticide appliers, biocides, and birth defects in rural Minnesota. Environ Health Perspect. 1996 Apr;104(4):394–399. doi: 10.1289/ehp.96104394. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gray L. E., Jr, Kelce W. R. Latent effects of pesticides and toxic substances on sexual differentiation of rodents. Toxicol Ind Health. 1996 May-Aug;12(3-4):515–531. doi: 10.1177/074823379601200323. [DOI] [PubMed] [Google Scholar]
  11. Gray L. E., Jr, Ostby J. S., Kelce W. R. Developmental effects of an environmental antiandrogen: the fungicide vinclozolin alters sex differentiation of the male rat. Toxicol Appl Pharmacol. 1994 Nov;129(1):46–52. doi: 10.1006/taap.1994.1227. [DOI] [PubMed] [Google Scholar]
  12. Grocock C. A., Charlton H. M., Pike M. C. Role of the fetal pituitary in cryptorchidism induced by exogenous maternal oestrogen during pregnancy in mice. J Reprod Fertil. 1988 May;83(1):295–300. doi: 10.1530/jrf.0.0830295. [DOI] [PubMed] [Google Scholar]
  13. Irvine S., Cawood E., Richardson D., MacDonald E., Aitken J. Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years. BMJ. 1996 Feb 24;312(7029):467–471. doi: 10.1136/bmj.312.7029.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kelce W. R., Monosson E., Gamcsik M. P., Laws S. C., Gray L. E., Jr Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites. Toxicol Appl Pharmacol. 1994 Jun;126(2):276–285. doi: 10.1006/taap.1994.1117. [DOI] [PubMed] [Google Scholar]
  15. Kristensen P., Irgens L. M., Andersen A., Bye A. S., Sundheim L. Birth defects among offspring of Norwegian farmers, 1967-1991. Epidemiology. 1997 Sep;8(5):537–544. doi: 10.1097/00001648-199709000-00011. [DOI] [PubMed] [Google Scholar]
  16. Källén B., Bertollini R., Castilla E., Czeizel A., Knudsen L. B., Martinez-Frias M. L., Mastroiacovo P., Mutchinick O. A joint international study on the epidemiology of hypospadias. Acta Paediatr Scand Suppl. 1986;324:1–52. doi: 10.1111/j.1651-2227.1986.tb14935.x. [DOI] [PubMed] [Google Scholar]
  17. Paulozzi L. J., Erickson J. D., Jackson R. J. Hypospadias trends in two US surveillance systems. Pediatrics. 1997 Nov;100(5):831–834. doi: 10.1542/peds.100.5.831. [DOI] [PubMed] [Google Scholar]
  18. Restrepo M., Muñoz N., Day N., Parra J. E., Hernandez C., Blettner M., Giraldo A. Birth defects among children born to a population occupationally exposed to pesticides in Colombia. Scand J Work Environ Health. 1990 Aug;16(4):239–246. doi: 10.5271/sjweh.1789. [DOI] [PubMed] [Google Scholar]
  19. Schwartz D. A., Newsum L. A., Heifetz R. M. Parental occupation and birth outcome in an agricultural community. Scand J Work Environ Health. 1986 Feb;12(1):51–54. doi: 10.5271/sjweh.2180. [DOI] [PubMed] [Google Scholar]
  20. Sharpe R. M., Skakkebaek N. E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet. 1993 May 29;341(8857):1392–1395. doi: 10.1016/0140-6736(93)90953-e. [DOI] [PubMed] [Google Scholar]
  21. Soto A. M., Chung K. L., Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect. 1994 Apr;102(4):380–383. doi: 10.1289/ehp.94102380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Swan S. H., Elkin E. P., Fenster L. Have sperm densities declined? A reanalysis of global trend data. Environ Health Perspect. 1997 Nov;105(11):1228–1232. doi: 10.1289/ehp.971051228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Van Waeleghem K., De Clercq N., Vermeulen L., Schoonjans F., Comhaire F. Deterioration of sperm quality in young healthy Belgian men. Hum Reprod. 1996 Feb;11(2):325–329. doi: 10.1093/humrep/11.2.325. [DOI] [PubMed] [Google Scholar]
  24. Vorherr H., Messer R. H., Vorherr U. F., Jordan S. W., Kornfeld M. Teratogenesis and carcinogenesis in rat offspring after transplacental and transmammary exposure to diethylstilbestrol. Biochem Pharmacol. 1979 Jun 15;28(12):1865–1877. doi: 10.1016/0006-2952(79)90638-5. [DOI] [PubMed] [Google Scholar]
  25. White R., Jobling S., Hoare S. A., Sumpter J. P., Parker M. G. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology. 1994 Jul;135(1):175–182. doi: 10.1210/endo.135.1.8013351. [DOI] [PubMed] [Google Scholar]

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