Abstract
IL-8 is a chemotactic cytokine with proinflammatory and growth-promoting activities. The release of IL-8 was measured in supernatants of cultured peripheral blood monocytes (PBM) that were obtained from patients with glomerulonephritis (GN) and healthy controls. Spontaneous and lipopolysaccharide (LPS)-induced IL-8 release was significantly higher in PBM isolated from patients with IgA nephropathy (IgAN) and membranous nephropathy (MN) compared with normal controls. These results raise the question of whether IL-8 contributes to the ongoing pathogenesis of GN. We cannot relate IL-8 release to clinical and laboratory parameters in IgAN and MN patients. Thus, disease progression in vivo may not be accompanied by increased or sustained IL-8 release.
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Selected References
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- Abbott F., Ryan J. J., Ceska M., Matsushima K., Sarraf C. E., Rees A. J. Interleukin-1 beta stimulates human mesangial cells to synthesize and release interleukins-6 and -8. Kidney Int. 1991 Oct;40(4):597–605. doi: 10.1038/ki.1991.250. [DOI] [PubMed] [Google Scholar]
- Brown Z., Strieter R. M., Chensue S. W., Ceska M., Lindley I., Neild G. H., Kunkel S. L., Westwick J. Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8. Kidney Int. 1991 Jul;40(1):86–90. doi: 10.1038/ki.1991.184. [DOI] [PubMed] [Google Scholar]
- Kusner D. J., Luebbers E. L., Nowinski R. J., Konieczkowski M., King C. H., Sedor J. R. Cytokine- and LPS-induced synthesis of interleukin-8 from human mesangial cells. Kidney Int. 1991 Jun;39(6):1240–1248. doi: 10.1038/ki.1991.157. [DOI] [PubMed] [Google Scholar]
- Matsumoto K., Dowling J., Atkins R. C. Production of interleukin 1 in glomerular cell cultures from patients with rapidly progressive crescentic glomerulonephritis. Am J Nephrol. 1988;8(6):463–470. doi: 10.1159/000167656. [DOI] [PubMed] [Google Scholar]
- Matsumoto K. Increased release of tumor necrosis factor-alpha by monocytes from patients with glomerulonephritis. Clin Nephrol. 1993 Sep;40(3):148–154. [PubMed] [Google Scholar]
- Matsumoto K. Interleukin-1 production by monocytes from patients with glomerulonephritis after stimulation in vitro with soluble immune complexes. Clin Nephrol. 1991 Dec;36(6):267–273. [PubMed] [Google Scholar]
- Matsumoto K. Production of interleukin-1 by glomerular macrophages in nephrotoxic serum nephritis. Am J Nephrol. 1990;10(6):502–506. doi: 10.1159/000168176. [DOI] [PubMed] [Google Scholar]
- Matsumoto K. Production of tumor necrosis factor-alpha by glomerular macrophages in nephrotoxic serum nephritis. Clin Nephrol. 1992 Oct;38(4):237–238. [PubMed] [Google Scholar]
- Schröder J. M., Mrowietz U., Morita E., Christophers E. Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J Immunol. 1987 Nov 15;139(10):3474–3483. [PubMed] [Google Scholar]
- Werber H. I., Emancipator S. N., Tykocinski M. L., Sedor J. R. The interleukin 1 gene is expressed by rat glomerular mesangial cells and is augmented in immune complex glomerulonephritis. J Immunol. 1987 May 15;138(10):3207–3212. [PubMed] [Google Scholar]
- Zoja C., Wang J. M., Bettoni S., Sironi M., Renzi D., Chiaffarino F., Abboud H. E., Van Damme J., Mantovani A., Remuzzi G. Interleukin-1 beta and tumor necrosis factor-alpha induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells. Am J Pathol. 1991 Apr;138(4):991–1003. [PMC free article] [PubMed] [Google Scholar]