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. 1993 Oct;94(1):38–42. doi: 10.1111/j.1365-2249.1993.tb05974.x

Selective impairment of T lymphocyte activation through the T cell receptor/CD3 complex after cytomegalovirus infection.

M Timón 1, A Arnaiz-Villena 1, J Ruiz-Contreras 1, J T Ramos-Amador 1, A Pacheco 1, J R Regueiro 1
PMCID: PMC1534390  PMID: 8403514

Abstract

Cytomegalovirus (CMV) infection is reported to cause transient immunosuppression in man. In this study we have analysed the effect of CMV on T lymphocyte function in 29 children diagnosed for acute CMV infection. Peripheral blood mononuclear cells (PBMC) obtained from the patients showed a significant specific impairment in their proliferative response to enterotoxins A and C1, to concanavalin A and to the anti-CD3 MoAb OKT3. The impaired responses were corrected with exogenous IL-2. In contrast, stimulation using phytohaemagglutinin, as well as activation signals delivered through the surface molecules CD26 or CD28, elicited normal proliferative responses in CMV PBMC. The results indicate that the T cell anergy associated with CMV infection is restricted to the T cell receptor/CD3 activation pathway.

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Selected References

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