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. 1993 Dec;94(3):395–397. doi: 10.1111/j.1365-2249.1993.tb08207.x

What is the role of human intestinal intraepithelial lymphocytes?

L K Trejdosiewicz
PMCID: PMC1534448  PMID: 7504597

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Balk S. P., Ebert E. C., Blumenthal R. L., McDermott F. V., Wucherpfennig K. W., Landau S. B., Blumberg R. S. Oligoclonal expansion and CD1 recognition by human intestinal intraepithelial lymphocytes. Science. 1991 Sep 20;253(5026):1411–1415. doi: 10.1126/science.1716785. [DOI] [PubMed] [Google Scholar]
  2. Blumberg R. S., Yockey C. E., Gross G. G., Ebert E. C., Balk S. P. Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes. J Immunol. 1993 Jun 1;150(11):5144–5153. [PubMed] [Google Scholar]
  3. Cepek K. L., Parker C. M., Madara J. L., Brenner M. B. Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol. 1993 Apr 15;150(8 Pt 1):3459–3470. [PubMed] [Google Scholar]
  4. Dalton H. R., Dipaolo M. C., Sachdev G. K., Crotty B., Hoang P., Jewell D. P. Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens. Clin Exp Immunol. 1993 Jul;93(1):97–102. doi: 10.1111/j.1365-2249.1993.tb06503.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ebert E. C. Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities. Clin Exp Immunol. 1990 Oct;82(1):81–85. doi: 10.1111/j.1365-2249.1990.tb05407.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ebert E. C. Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities. Clin Exp Immunol. 1990 Oct;82(1):81–85. doi: 10.1111/j.1365-2249.1990.tb05407.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ebert E. C. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology. 1989 Dec;97(6):1372–1381. doi: 10.1016/0016-5085(89)90379-x. [DOI] [PubMed] [Google Scholar]
  8. Ebert E. C., Roberts A. I. Lymphokine-activated killing by human intestinal lymphocytes. Cell Immunol. 1993 Jan;146(1):107–116. doi: 10.1006/cimm.1993.1010. [DOI] [PubMed] [Google Scholar]
  9. Halstensen T. S., Brandtzaeg P. Activated T lymphocytes in the celiac lesion: non-proliferative activation (CD25) of CD4+ alpha/beta cells in the lamina propria but proliferation (Ki-67) of alpha/beta and gamma/delta cells in the epithelium. Eur J Immunol. 1993 Feb;23(2):505–510. doi: 10.1002/eji.1830230231. [DOI] [PubMed] [Google Scholar]
  10. Hoang P., Crotty B., Dalton H. R., Jewell D. P. Epithelial cells bearing class II molecules stimulate allogeneic human colonic intraepithelial lymphocytes. Gut. 1992 Aug;33(8):1089–1093. doi: 10.1136/gut.33.8.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hoang P., Dalton H. R., Jewell D. P. Human colonic intra-epithelial lymphocytes are suppressor cells. Clin Exp Immunol. 1991 Sep;85(3):498–503. doi: 10.1111/j.1365-2249.1991.tb05756.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Jarry A., Cerf-Bensussan N., Brousse N., Selz F., Guy-Grand D. Subsets of CD3+ (T cell receptor alpha/beta or gamma/delta) and CD3- lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol. 1990 May;20(5):1097–1103. doi: 10.1002/eji.1830200523. [DOI] [PubMed] [Google Scholar]
  13. Kaiserlian D., Rigal D., Abello J., Revillard J. P. Expression, function and regulation of the intercellular adhesion molecule-1 (ICAM-1) on human intestinal epithelial cell lines. Eur J Immunol. 1991 Oct;21(10):2415–2421. doi: 10.1002/eji.1830211018. [DOI] [PubMed] [Google Scholar]
  14. Kvale D., Krajci P., Brandtzaeg P. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines. Scand J Immunol. 1992 Jun;35(6):669–676. doi: 10.1111/j.1365-3083.1992.tb02973.x. [DOI] [PubMed] [Google Scholar]
  15. Malizia G., Calabrese A., Cottone M., Raimondo M., Trejdosiewicz L. K., Smart C. J., Oliva L., Pagliaro L. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. Gastroenterology. 1991 Jan;100(1):150–159. doi: 10.1016/0016-5085(91)90595-c. [DOI] [PubMed] [Google Scholar]
  16. Mayer L., Panja A., Li Y., Siden E., Pizzimenti A., Gerardi F., Chandswang N. Unique features of antigen presentation in the intestine. Ann N Y Acad Sci. 1992;664:39–46. doi: 10.1111/j.1749-6632.1992.tb39747.x. [DOI] [PubMed] [Google Scholar]
  17. Panja A., Blumberg R. S., Balk S. P., Mayer L. CD1d is involved in T cell-intestinal epithelial cell interactions. J Exp Med. 1993 Sep 1;178(3):1115–1119. doi: 10.1084/jem.178.3.1115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Roberts A. I., O'Connell S. M., Biancone L., Brolin R. E., Ebert E. C. Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism. Clin Exp Immunol. 1993 Dec;94(3):527–532. doi: 10.1111/j.1365-2249.1993.tb08229.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Roberts A. I., O'Connell S. M., Ebert E. C. Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1 and CD11a. Cancer Res. 1993 Apr 1;53(7):1608–1611. [PubMed] [Google Scholar]
  20. Rocha B., Vassalli P., Guy-Grand D. The extrathymic T-cell development pathway. Immunol Today. 1992 Nov;13(11):449–454. doi: 10.1016/0167-5699(92)90074-H. [DOI] [PubMed] [Google Scholar]
  21. Russell G. J., Nagler-Anderson C., Anderson P., Bhan A. K. Cytotoxic potential of intraepithelial lymphocytes (IELs). Presence of TIA-1, the cytolytic granule-associated protein, in human IELs in normal and diseased intestine. Am J Pathol. 1993 Aug;143(2):350–354. [PMC free article] [PubMed] [Google Scholar]
  22. Rüthlein J., Heinze G., Auer I. O. Anti-CD2 and anti-CD3 induced T cell cytotoxicity of human intraepithelial and lamina propria lymphocytes. Gut. 1992 Dec;33(12):1626–1632. doi: 10.1136/gut.33.12.1626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Sarnacki S., Bègue B., Buc H., Le Deist F., Cerf-Bensussan N. Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the beta 7-containing integrin defined by HML-1 monoclonal antibody. Eur J Immunol. 1992 Nov;22(11):2887–2892. doi: 10.1002/eji.1830221120. [DOI] [PubMed] [Google Scholar]
  24. Schwartz R. H. A cell culture model for T lymphocyte clonal anergy. Science. 1990 Jun 15;248(4961):1349–1356. doi: 10.1126/science.2113314. [DOI] [PubMed] [Google Scholar]
  25. Simpson E. Suppression of the immune response by cytotoxic T cells. Nature. 1988 Dec 1;336(6198):426–426. doi: 10.1038/336426a0. [DOI] [PubMed] [Google Scholar]
  26. Smart C. J., Calabrese A., Oakes D. J., Howdle P. D., Trejdosiewicz L. K. Expression of the LFA-1 beta 2 integrin (CD11a/CD18) and ICAM-1 (CD54) in normal and coeliac small bowel mucosa. Scand J Immunol. 1991 Sep;34(3):299–305. doi: 10.1111/j.1365-3083.1991.tb01550.x. [DOI] [PubMed] [Google Scholar]
  27. Smart C. J., Trejdosiewicz L. K., Badr-el-Din S., Heatley R. V. T lymphocytes of the human colonic mucosa: functional and phenotypic analysis. Clin Exp Immunol. 1988 Jul;73(1):63–69. [PMC free article] [PubMed] [Google Scholar]
  28. Sugita-Konishi Y., Smart C. J., Trejdosiewicz L. K. Regulation of intestinal immunoglobulin production in response to dietary ovalbumin. Int Arch Allergy Immunol. 1992;98(1):64–69. doi: 10.1159/000236165. [DOI] [PubMed] [Google Scholar]
  29. Taunk J., Roberts A. I., Ebert E. C. Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. Gastroenterology. 1992 Jan;102(1):69–75. doi: 10.1016/0016-5085(92)91785-3. [DOI] [PubMed] [Google Scholar]
  30. Teitell M., Mescher M. F., Olson C. A., Littman D. R., Kronenberg M. The thymus leukemia antigen binds human and mouse CD8. J Exp Med. 1991 Nov 1;174(5):1131–1138. doi: 10.1084/jem.174.5.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Trejdosiewicz L. K. Intestinal intraepithelial lymphocytes and lymphoepithelial interactions in the human gastrointestinal mucosa. Immunol Lett. 1992 Mar;32(1):13–19. doi: 10.1016/0165-2478(92)90192-q. [DOI] [PubMed] [Google Scholar]
  32. Van Kerckhove C., Russell G. J., Deusch K., Reich K., Bhan A. K., DerSimonian H., Brenner M. B. Oligoclonality of human intestinal intraepithelial T cells. J Exp Med. 1992 Jan 1;175(1):57–63. doi: 10.1084/jem.175.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Wu M., van Kaer L., Itohara S., Tonegawa S. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. J Exp Med. 1991 Jul 1;174(1):213–218. doi: 10.1084/jem.174.1.213. [DOI] [PMC free article] [PubMed] [Google Scholar]

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