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. 1994 Jun;96(3):422–426. doi: 10.1111/j.1365-2249.1994.tb06045.x

Production of tumour necrosis factors by human T cells stimulated by a superantigen, toxic shock syndrome toxin-1.

H Akatsuka 1, K Imanishi 1, K Inada 1, H Yamashita 1, M Yoshida 1, T Uchiyama 1
PMCID: PMC1534580  PMID: 7911750

Abstract

The capacity of human T cell subsets, CD4+ or CD8+ T cells, to produce tumour necrosis factors (TNF-alpha and TNF-beta) upon stimulation with toxic shock syndrome toxin-1 (TSST-1) and the requirement for MHC class II molecules on accessory cells (AC) in the response were investigated. The capacity of CD4+ T cells was much higher than that of CD8+ T cells in TSST-1-induced production of TNF-alpha and TNF-beta. The expression of MHC class II molecules on AC was required in the response.

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Selected References

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