Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1994 Jan;95(1):60–65. doi: 10.1111/j.1365-2249.1994.tb06015.x

Soluble intercellular adhesion molecule-1 (sICAM-1) as a marker of disease relapse in idiopathic uveoretinitis.

A G Zaman 1, C Edelsten 1, M R Stanford 1, E M Graham 1, B A Ellis 1, H Direskeneli 1, D P D'Cruz 1, G R Hughes 1, D C Dumonde 1, G R Wallace 1
PMCID: PMC1534625  PMID: 7507016

Abstract

This study reports the results of a point prevalence study of markers of endothelial dysfunction in the serum of patients with idiopathic uveoretinitis. sICAM-1, soluble endothelial leucocyte adhesion molecule (sELAM), anti-endothelial cell antibodies (AECA) and von Willebrand factor (vWF) levels were measured in 32 patients with isolated idiopathic uveoretinitis and seven with uveitis in association with systemic disease, using commercial and in-house ELISAs. Raised levels of AECA were found in 31% of patients with isolated uveitis, vWF in 28%, sELAM in 15.6% and sICAM-1 in 31%. Further analysis revealed that raised sICAM-1 levels were closely associated with recent relapse of disease (P = 0.00003). Patients with accompanying systemic disease were found to have a similar prevalence of these serum abnormalities to those with isolated ocular disease. In conclusion, vascular endothelial dysfunction may contribute to pathogenesis in uveoretinitis, and in particular sICAM-1 may prove a marker of disease relapse in this condition.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arocker-Mettinger E., Steurer-Georgiew L., Steurer M., Huber-Spitzy V., Hoelzl E., Grabner G., Kuchar A. Circulating ICAM-1 levels in serum of uveitis patients. Curr Eye Res. 1992;11 (Suppl):161–166. doi: 10.3109/02713689208999527. [DOI] [PubMed] [Google Scholar]
  2. Aydìntug A. O., Tokgöz G., D'Cruz D. P., Gürler A., Cervera R., Düzgün N., Atmaca L. S., Khamashta M. A., Hughes G. R. Antibodies to endothelial cells in patients with Behçet's disease. Clin Immunol Immunopathol. 1993 May;67(2):157–162. doi: 10.1006/clin.1993.1059. [DOI] [PubMed] [Google Scholar]
  3. Baguley E., Hughes G. R. Antiendothelial cell antibodies. J Rheumatol. 1989 Jun;16(6):716–717. [PubMed] [Google Scholar]
  4. Bevilacqua M. P., Stengelin S., Gimbrone M. A., Jr, Seed B. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science. 1989 Mar 3;243(4895):1160–1165. doi: 10.1126/science.2466335. [DOI] [PubMed] [Google Scholar]
  5. Bleil L., Manger B., Winkler T. H., Herrman M., Burmester G. R., Krapf F. E., Kalden J. R. The role of antineutrophil cytoplasm antibodies, anticardiolipin antibodies, von Willebrand factor antigen, and fibronectin for the diagnosis of systemic vasculitis. J Rheumatol. 1991 Aug;18(8):1199–1206. [PubMed] [Google Scholar]
  6. D'Cruz D. P., Houssiau F. A., Ramirez G., Baguley E., McCutcheon J., Vianna J., Haga H. J., Swana G. T., Khamashta M. A., Taylor J. C. Antibodies to endothelial cells in systemic lupus erythematosus: a potential marker for nephritis and vasculitis. Clin Exp Immunol. 1991 Aug;85(2):254–261. doi: 10.1111/j.1365-2249.1991.tb05714.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Deschênes J., Char D. H., Kaleta S. Activated T lymphocytes in uveitis. Br J Ophthalmol. 1988 Feb;72(2):83–87. doi: 10.1136/bjo.72.2.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Dick A. D., Cheng Y. F., Purdie A. T., Liversidge J., Forrester J. V. Immunocytochemical analysis of blood lymphocytes in uveitis. Eye (Lond) 1992;6(Pt 6):643–647. doi: 10.1038/eye.1992.138. [DOI] [PubMed] [Google Scholar]
  9. Doekes G., van der Gaag R., Rothova A., van Kooyk Y., Broersma L., Zaal M. J., Dijkman G., Fortuin M. E., Baarsma G. S., Kijlstra A. Humoral and cellular immune responsiveness to human S-antigen in uveitis. Curr Eye Res. 1987 Jul;6(7):909–919. doi: 10.3109/02713688709034859. [DOI] [PubMed] [Google Scholar]
  10. Dougherty G. J., Murdoch S., Hogg N. The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response. Eur J Immunol. 1988 Jan;18(1):35–39. doi: 10.1002/eji.1830180107. [DOI] [PubMed] [Google Scholar]
  11. Duguid I. G., Boyd A. W., Mandel T. E. Adhesion molecules are expressed in the human retina and choroid. Curr Eye Res. 1992;11 (Suppl):153–159. doi: 10.3109/02713689208999526. [DOI] [PubMed] [Google Scholar]
  12. Dumonde D. C., Kasp-Grochowska E., Graham E., Sanders M. D., Faure J. P., de Kozak Y., van Tuyen V. Anti-retinal autoimmunity and circulating immune complexes in patients with retinal vasculitis. Lancet. 1982 Oct 9;2(8302):787–792. doi: 10.1016/s0140-6736(82)92679-4. [DOI] [PubMed] [Google Scholar]
  13. Dustin M. L., Rothlein R., Bhan A. K., Dinarello C. A., Springer T. A. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 1;137(1):245–254. [PubMed] [Google Scholar]
  14. Edelsten C., D'Cruz D., Hughes G. R., Graham E. M. Anti-endothelial cell antibodies in retinal vasculitis. Curr Eye Res. 1992;11 (Suppl):203–208. doi: 10.3109/02713689208999534. [DOI] [PubMed] [Google Scholar]
  15. Elner S. G., Elner V. M., Pavilack M. A., Todd R. F., 3rd, Mayo-Bond L., Franklin W. A., Strieter R. M., Kunkel S. L., Huber A. R. Modulation and function of intercellular adhesion molecule-1 (CD54) on human retinal pigment epithelial cells. Lab Invest. 1992 Feb;66(2):200–211. [PubMed] [Google Scholar]
  16. Forrester J. V., Liversidge J., Dua H. S., Towler H., McMenamin P. G. Comparison of clinical and experimental uveitis. Curr Eye Res. 1990;9 (Suppl):75–84. doi: 10.3109/02713689008999424. [DOI] [PubMed] [Google Scholar]
  17. Furukawa S., Imai K., Matsubara T., Yone K., Yachi A., Okumura K., Yabuta K. Increased levels of circulating intercellular adhesion molecule 1 in Kawasaki disease. Arthritis Rheum. 1992 Jun;35(6):672–677. doi: 10.1002/art.1780350611. [DOI] [PubMed] [Google Scholar]
  18. Gearing A. J., Hemingway I., Pigott R., Hughes J., Rees A. J., Cashman S. J. Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1, and VCAM-1: pathological significance. Ann N Y Acad Sci. 1992 Dec 4;667:324–331. doi: 10.1111/j.1749-6632.1992.tb51633.x. [DOI] [PubMed] [Google Scholar]
  19. Graham E. M., Stanford M. R., Sanders M. D., Kasp E., Dumonde D. C. A point prevalence study of 150 patients with idiopathic retinal vasculitis: 1. Diagnostic value of ophthalmological features. Br J Ophthalmol. 1989 Sep;73(9):714–721. doi: 10.1136/bjo.73.9.714. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hogg N. Roll, roll, roll your leucocyte gently down the vein.... Immunol Today. 1992 Apr;13(4):113–115. doi: 10.1016/0167-5699(92)90103-E. [DOI] [PubMed] [Google Scholar]
  21. Jaffe E. A., Hoyer L. W., Nachman R. L. Synthesis of von Willebrand factor by cultured human endothelial cells. Proc Natl Acad Sci U S A. 1974 May;71(5):1906–1909. doi: 10.1073/pnas.71.5.1906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kahn L. S., Schlaegel T. F., Jr, Weber J. C., Biegel A. Serum immunoglobulins and uveitis. Arch Ophthalmol. 1983 Mar;101(3):458–459. doi: 10.1001/archopht.1983.01040010458025. [DOI] [PubMed] [Google Scholar]
  23. King D. G., Grizzard W. S., Sever R. J., Espinoza L. Serpiginous choroidopathy associated with elevated factor VIII-von Willebrand factor antigen. Retina. 1990;10(2):97–101. doi: 10.1097/00006982-199004000-00001. [DOI] [PubMed] [Google Scholar]
  24. Leeuwenberg J. F., Smeets E. F., Neefjes J. J., Shaffer M. A., Cinek T., Jeunhomme T. M., Ahern T. J., Buurman W. A. E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology. 1992 Dec;77(4):543–549. [PMC free article] [PubMed] [Google Scholar]
  25. Lightman S., Chan C. C. Immune mechanisms in choroido-retinal inflammation in man. Eye (Lond) 1990;4(Pt 2):345–353. doi: 10.1038/eye.1990.47. [DOI] [PubMed] [Google Scholar]
  26. Liversidge J., Sewell H. F., Forrester J. V. Interactions between lymphocytes and cells of the blood-retina barrier: mechanisms of T lymphocyte adhesion to human retinal capillary endothelial cells and retinal pigment epithelial cells in vitro. Immunology. 1990 Nov;71(3):390–396. [PMC free article] [PubMed] [Google Scholar]
  27. Luscinskas F. W., Brock A. F., Arnaout M. A., Gimbrone M. A., Jr Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 1;142(7):2257–2263. [PubMed] [Google Scholar]
  28. Makgoba M. W., Sanders M. E., Ginther Luce G. E., Dustin M. L., Springer T. A., Clark E. A., Mannoni P., Shaw S. ICAM-1 a ligand for LFA-1-dependent adhesion of B, T and myeloid cells. Nature. 1988 Jan 7;331(6151):86–88. doi: 10.1038/331086a0. [DOI] [PubMed] [Google Scholar]
  29. Murray P. I., Young D. W. Soluble interleukin-2 receptors in retinal vasculitis. Curr Eye Res. 1992;11 (Suppl):193–195. doi: 10.3109/02713689208999532. [DOI] [PubMed] [Google Scholar]
  30. Nachman R., Levine R., Jaffe E. A. Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes. J Clin Invest. 1977 Oct;60(4):914–921. doi: 10.1172/JCI108846. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Newman W., Beall L. D., Carson C. W., Hunder G. G., Graben N., Randhawa Z. I., Gopal T. V., Wiener-Kronish J., Matthay M. A. Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock. J Immunol. 1993 Jan 15;150(2):644–654. [PubMed] [Google Scholar]
  32. Nusinow S. R., Federici A. B., Zimmerman T. S., Curd J. G. Increased von Willebrand factor antigen in the plasma of patients with vasculitis. Arthritis Rheum. 1984 Dec;27(12):1405–1410. doi: 10.1002/art.1780271211. [DOI] [PubMed] [Google Scholar]
  33. Nussenblatt R. B., Salinas-Carmona M., Leake W., Scher I. T lymphocyte subsets in uveitis. Am J Ophthalmol. 1983 May;95(5):614–621. doi: 10.1016/0002-9394(83)90379-3. [DOI] [PubMed] [Google Scholar]
  34. Picker L. J., Kishimoto T. K., Smith C. W., Warnock R. A., Butcher E. C. ELAM-1 is an adhesion molecule for skin-homing T cells. Nature. 1991 Feb 28;349(6312):796–799. doi: 10.1038/349796a0. [DOI] [PubMed] [Google Scholar]
  35. Pober J. S., Gimbrone M. A., Jr, Lapierre L. A., Mendrick D. L., Fiers W., Rothlein R., Springer T. A. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol. 1986 Sep 15;137(6):1893–1896. [PubMed] [Google Scholar]
  36. Porta M., Townsend C., Clover G. M., Nanson M., Alderson A. R., McCraw A., Kohner E. M. Evidence for functional endothelial cell damage in early diabetic retinopathy. Diabetologia. 1981 Jun;20(6):597–601. doi: 10.1007/BF00257426. [DOI] [PubMed] [Google Scholar]
  37. Rothlein R., Mainolfi E. A., Czajkowski M., Marlin S. D. A form of circulating ICAM-1 in human serum. J Immunol. 1991 Dec 1;147(11):3788–3793. [PubMed] [Google Scholar]
  38. Sanders M. D. Duke-Elder lecture. Retinal arteritis, retinal vasculitis and autoimmune retinal vasculitis. Eye (Lond) 1987;1(Pt 4):441–465. doi: 10.1038/eye.1987.68. [DOI] [PubMed] [Google Scholar]
  39. Sharief M. K., Noori M. A., Ciardi M., Cirelli A., Thompson E. J. Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage. J Neuroimmunol. 1993 Mar;43(1-2):15–21. doi: 10.1016/0165-5728(93)90070-f. [DOI] [PubMed] [Google Scholar]
  40. Shimizu Y., Newman W., Gopal T. V., Horgan K. J., Graber N., Beall L. D., van Seventer G. A., Shaw S. Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. J Cell Biol. 1991 Jun;113(5):1203–1212. doi: 10.1083/jcb.113.5.1203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Short P. E., Williams C. E., Picken A. M., Hill F. G. Factor VIII related antigen: an improved enzyme immunoassay. Med Lab Sci. 1982 Oct;39(4):351–355. [PubMed] [Google Scholar]
  42. Simmons D., Makgoba M. W., Seed B. ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature. 1988 Feb 18;331(6157):624–627. doi: 10.1038/331624a0. [DOI] [PubMed] [Google Scholar]
  43. Tanaka Y., Tsukada N., Koh C. S., Yanagisawa N. Anti-endothelial cell antibodies and circulating immune complexes in the sera of patients with multiple sclerosis. J Neuroimmunol. 1987 Dec;17(1):49–59. doi: 10.1016/0165-5728(87)90030-0. [DOI] [PubMed] [Google Scholar]
  44. Whitcup S. M., Chan C. C., Li Q., Nussenblatt R. B. Expression of cell adhesion molecules in posterior uveitis. Arch Ophthalmol. 1992 May;110(5):662–666. doi: 10.1001/archopht.1992.01080170084029. [DOI] [PubMed] [Google Scholar]
  45. de Smet M. D., Yamamoto J. H., Mochizuki M., Gery I., Singh V. K., Shinohara T., Wiggert B., Chader G. J., Nussenblatt R. B. Cellular immune responses of patients with uveitis to retinal antigens and their fragments. Am J Ophthalmol. 1990 Aug 15;110(2):135–142. doi: 10.1016/s0002-9394(14)76981-8. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES