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. 1994 Jan;95(1):166–172. doi: 10.1111/j.1365-2249.1994.tb06032.x

MHC class I, MHC class II and intercellular adhesion molecule-1 (ICAM-1) expression in inflammatory myopathies.

E Bartoccioni 1, S Gallucci 1, F Scuderi 1, E Ricci 1, S Servidei 1, A Broccolini 1, P Tonali 1
PMCID: PMC1534629  PMID: 7507012

Abstract

We investigated the relationship between the MHC-I, MHC-II and intercellular adhesion molecule-1 (ICAM-1) expression on myofibres and the presence of inflammatory cells in muscle specimens of 18 patients with inflammatory myopathies (nine polymyositis, seven dermatomyositis, two inclusion body myositis). We observed MHC-I expression in muscle fibres, infiltrating mononuclear cells and endothelial cells in every specimen. In seven patients, some muscle fibres were MHC-II-positive for the DR antigen, while the DP and DQ antigens were absent. ICAM-1 expression, detected in seven patients, was found in clusters of myofibres, associated with a marked MHC-I positivity and a widespread mononuclear infiltration. Most of the ICAM-1-positive fibres were regenerating fibres. Furthermore, some fibres expressed both ICAM-1 and DR antigens near infiltrating cells. This finding could support the hypothesis that myofibres may themselves be the site of autosensitization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altmann D. M., Hogg N., Trowsdale J., Wilkinson D. Cotransfection of ICAM-1 and HLA-DR reconstitutes human antigen-presenting cell function in mouse L cells. Nature. 1989 Apr 6;338(6215):512–514. doi: 10.1038/338512a0. [DOI] [PubMed] [Google Scholar]
  2. Appleyard S. T., Dunn M. J., Dubowitz V., Rose M. L. Increased expression of HLA ABC class I antigens by muscle fibres in Duchenne muscular dystrophy, inflammatory myopathy, and other neuromuscular disorders. Lancet. 1985 Feb 16;1(8425):361–363. doi: 10.1016/s0140-6736(85)91384-4. [DOI] [PubMed] [Google Scholar]
  3. Arahata K., Engel A. G. Monoclonal antibody analysis of mononuclear cells in myopathies. V: Identification and quantitation of T8+ cytotoxic and T8+ suppressor cells. Ann Neurol. 1988 May;23(5):493–499. doi: 10.1002/ana.410230511. [DOI] [PubMed] [Google Scholar]
  4. Cifuentes-Diaz C., Delaporte C., Dautréaux B., Charron D., Fardeau M. Class II MHC antigens in normal human skeletal muscle. Muscle Nerve. 1992 Mar;15(3):295–302. doi: 10.1002/mus.880150307. [DOI] [PubMed] [Google Scholar]
  5. Daar A. S., Fuggle S. V., Fabre J. W., Ting A., Morris P. J. The detailed distribution of HLA-A, B, C antigens in normal human organs. Transplantation. 1984 Sep;38(3):287–292. doi: 10.1097/00007890-198409000-00018. [DOI] [PubMed] [Google Scholar]
  6. Daar A. S., Fuggle S. V., Fabre J. W., Ting A., Morris P. J. The detailed distribution of MHC Class II antigens in normal human organs. Transplantation. 1984 Sep;38(3):293–298. doi: 10.1097/00007890-198409000-00019. [DOI] [PubMed] [Google Scholar]
  7. Dalakas M. C. Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med. 1991 Nov 21;325(21):1487–1498. doi: 10.1056/NEJM199111213252107. [DOI] [PubMed] [Google Scholar]
  8. Dustin M. L., Rothlein R., Bhan A. K., Dinarello C. A., Springer T. A. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 1;137(1):245–254. [PubMed] [Google Scholar]
  9. Dustin M. L., Springer T. A. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature. 1989 Oct 19;341(6243):619–624. doi: 10.1038/341619a0. [DOI] [PubMed] [Google Scholar]
  10. Emslie-Smith A. M., Arahata K., Engel A. G. Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies. Hum Pathol. 1989 Mar;20(3):224–231. doi: 10.1016/0046-8177(89)90128-7. [DOI] [PubMed] [Google Scholar]
  11. Emslie-Smith A. M., Engel A. G. Microvascular changes in early and advanced dermatomyositis: a quantitative study. Ann Neurol. 1990 Apr;27(4):343–356. doi: 10.1002/ana.410270402. [DOI] [PubMed] [Google Scholar]
  12. Goebels N., Michaelis D., Wekerle H., Hohlfeld R. Human myoblasts as antigen-presenting cells. J Immunol. 1992 Jul 15;149(2):661–667. [PubMed] [Google Scholar]
  13. Griffin J. D., Hercend T., Beveridge R., Schlossman S. F. Characterization of an antigen expressed by human natural killer cells. J Immunol. 1983 Jun;130(6):2947–2951. [PubMed] [Google Scholar]
  14. Hohlfeld R., Engel A. G. Coculture with autologous myotubes of cytotoxic T cells isolated from muscle in inflammatory myopathies. Ann Neurol. 1991 May;29(5):498–507. doi: 10.1002/ana.410290509. [DOI] [PubMed] [Google Scholar]
  15. Illa I., Leon-Monzon M., Dalakas M. C. Regenerating and denervated human muscle fibers and satellite cells express neural cell adhesion molecule recognized by monoclonal antibodies to natural killer cells. Ann Neurol. 1992 Jan;31(1):46–52. doi: 10.1002/ana.410310109. [DOI] [PubMed] [Google Scholar]
  16. Isenberg D. A., Rowe D., Shearer M., Novick D., Beverley P. C. Localization of interferons and interleukin 2 in polymyositis and muscular dystrophy. Clin Exp Immunol. 1986 Feb;63(2):450–458. [PMC free article] [PubMed] [Google Scholar]
  17. Karpati G., Pouliot Y., Carpenter S. Expression of immunoreactive major histocompatibility complex products in human skeletal muscles. Ann Neurol. 1988 Jan;23(1):64–72. doi: 10.1002/ana.410230111. [DOI] [PubMed] [Google Scholar]
  18. Kissel J. T., Halterman R. K., Rammohan K. W., Mendell J. R. The relationship of complement-mediated microvasculopathy to the histologic features and clinical duration of disease in dermatomyositis. Arch Neurol. 1991 Jan;48(1):26–30. doi: 10.1001/archneur.1991.00530130034016. [DOI] [PubMed] [Google Scholar]
  19. Makgoba M. W., Sanders M. E., Ginther Luce G. E., Gugel E. A., Dustin M. L., Springer T. A., Shaw S. Functional evidence that intercellular adhesion molecule-1 (ICAM-1) is a ligand for LFA-1-dependent adhesion in T cell-mediated cytotoxicity. Eur J Immunol. 1988 Apr;18(4):637–640. doi: 10.1002/eji.1830180423. [DOI] [PubMed] [Google Scholar]
  20. McDouall R. M., Dunn M. J., Dubowitz V. Expression of class I and class II MHC antigens in neuromuscular diseases. J Neurol Sci. 1989 Feb;89(2-3):213–226. doi: 10.1016/0022-510x(89)90023-3. [DOI] [PubMed] [Google Scholar]
  21. McMichael A. J. HLA restriction of human cytotoxic T cells. Springer Semin Immunopathol. 1980 May;3(1):3–22. doi: 10.1007/BF00199923. [DOI] [PubMed] [Google Scholar]
  22. Olsson T., Henriksson K. G., Klareskog L., Forsum U. HLA-DR expression, T lymphocyte phenotypes, OKM1 and OKT9 reactive cells in inflammatory myopathy. Muscle Nerve. 1985 Jun;8(5):419–425. doi: 10.1002/mus.880080512. [DOI] [PubMed] [Google Scholar]
  23. Patarroyo M., Prieto J., Rincon J., Timonen T., Lundberg C., Lindbom L., Asjö B., Gahmberg C. G. Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology. Immunol Rev. 1990 Apr;114:67–108. doi: 10.1111/j.1600-065x.1990.tb00562.x. [DOI] [PubMed] [Google Scholar]
  24. Rowe D., Isenberg D. A., Beverley P. C. Monoclonal antibodies to human leucocyte antigens in polymyositis and muscular dystrophy. Clin Exp Immunol. 1983 Nov;54(2):327–336. [PMC free article] [PubMed] [Google Scholar]
  25. Rutishauser U., Grumet M., Edelman G. M. Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture. J Cell Biol. 1983 Jul;97(1):145–152. doi: 10.1083/jcb.97.1.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Schalke B. B., Schmidt B., Toyka K., Hartung H. P. Pravastatin-associated inflammatory myopathy. N Engl J Med. 1992 Aug 27;327(9):649–650. doi: 10.1056/nejm199208273270919. [DOI] [PubMed] [Google Scholar]
  27. Schubert W., Zimmermann K., Cramer M., Starzinski-Powitz A. Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human skeletal muscle. Proc Natl Acad Sci U S A. 1989 Jan;86(1):307–311. doi: 10.1073/pnas.86.1.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Springer T. A. Adhesion receptors of the immune system. Nature. 1990 Aug 2;346(6283):425–434. doi: 10.1038/346425a0. [DOI] [PubMed] [Google Scholar]
  29. Volpes R., van den Oord J. J., Desmet V. J. Immunohistochemical study of adhesion molecules in liver inflammation. Hepatology. 1990 Jul;12(1):59–65. doi: 10.1002/hep.1840120110. [DOI] [PubMed] [Google Scholar]
  30. Weetman A. P., Cohen S., Makgoba M. W., Borysiewicz L. K. Expression of an intercellular adhesion molecule, ICAM-1, by human thyroid cells. J Endocrinol. 1989 Jul;122(1):185–191. doi: 10.1677/joe.0.1220185. [DOI] [PubMed] [Google Scholar]

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