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. 1994 Aug;97(2):280–283. doi: 10.1111/j.1365-2249.1994.tb06081.x

Evaluation of serum levels of soluble CD4, CD8 and beta 2-microglobulin in visceral human leishmaniasis.

G Vitale 1, C Mocciaro 1, R Malta 1, G Gambino 1, A Spinelli 1, C Giordano 1, G Stassi 1, F Arcoleo 1, S Milano 1, E Cillari 1
PMCID: PMC1534687  PMID: 8050177

Abstract

The levels of soluble CD4 (sCD4), sCD8 and beta 2-microglobulin (beta 2-M) were measured in sera from patients with visceral leishmaniasis during the course of infection. Levels of sCD4, sCD8 and beta 2-M were raised significantly above levels in normal sera and returned to the normal range after recovery. The decrease in the levels of sCD8 was related to a reduction of anaemia, leukopenia and thrombocytopenia. In contrast, sCD4 levels fluctuated during the period of infection. beta 2-M returned within normal range more rapidly than sCD8 secretion. Our results suggest that T cells are activated during infection, and that it is also possible that the raised levels of these soluble molecules play a role in the impairment of protective immunity.

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Selected References

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