Skip to main content
NCBI home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1994 Aug;97(2):239–241. doi: 10.1111/j.1365-2249.1994.tb06074.x

Serum soluble CD23 in patients with hypogammaglobulinaemia.

A S Bansal 1, M R Haeney 1, S Cochrane 1, R S Pumphrey 1, L M Green 1, M Bhavnani 1, P B Wilson 1
PMCID: PMC1534712  PMID: 8050171

Abstract

Serum levels of the soluble form of the low-affinity receptor for IgE (FcERII, CD23) (sCD23) are elevated in autoimmune conditions associated with hypergammaglobulinaemia and B cell hyperactivity. Very high levels of sCD23 are found in patients with B-chronic lymphatic leukaemia (B-CLL) who are, however, frequently hypogammaglobulinaemic. We therefore compared the serum levels of sCD23 in healthy controls (n = 33) with three conditions associated with hypogammaglobulinaemia (HGG) and varying B cell numbers: X-linked agammaglobulinaemia (XLA, n = 12), common variable immunodeficiency (CVI, n = 20) and B-chronic lymphatic leukaemia (n = 33). Serum levels of sCD23 showed a significant correlation with the CD19+ B cell count in both normals and patients with CVI (r = 0.65, P < 0.0001). Amongst the different clinical groups, serum levels of sCD23 were increased in the order XLA < CVI < normals < CLL (medians 2.5, 7.7, 11.1 and 540, respectively; P < 0.001 for all comparisons except CVI versus normals P < 0.03 in a one-tailed test). In the CVI group, serum sCD23 was lowest amongst four patients with low B cell numbers. There was no overlap in sCD23 between patients with XLA and this subgroup of CVI patients. Serum sCD23 is, therefore, derived predominantly from B cells, and is significantly related to the peripheral blood B cell count.

Full text

PDF
239

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bansal A. S., Ollier W., Marsh M. N., Pumphrey R. S., Wilson P. B. Variations in serum sCD23 in conditions with either enhanced humoral or cell-mediated immunity. Immunology. 1993 Jun;79(2):285–289. [PMC free article] [PubMed] [Google Scholar]
  2. Bansal A., Roberts T., Hay E. M., Kay R., Pumphrey R. S., Wilson P. B. Soluble CD23 levels are elevated in the serum of patients with primary Sjögren's syndrome and systemic lupus erythematosus. Clin Exp Immunol. 1992 Sep;89(3):452–455. doi: 10.1111/j.1365-2249.1992.tb06979.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dancescu M., Rubio-Trujillo M., Biron G., Bron D., Delespesse G., Sarfati M. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. J Exp Med. 1992 Nov 1;176(5):1319–1326. doi: 10.1084/jem.176.5.1319. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Delespesse G., Suter U., Mossalayi D., Bettler B., Sarfati M., Hofstetter H., Kilcherr E., Debre P., Dalloul A. Expression, structure, and function of the CD23 antigen. Adv Immunol. 1991;49:149–191. doi: 10.1016/s0065-2776(08)60776-2. [DOI] [PubMed] [Google Scholar]
  5. Desiderio S. Human genetics. Becoming B cells. Nature. 1993 Jan 21;361(6409):202–203. doi: 10.1038/361202a0. [DOI] [PubMed] [Google Scholar]
  6. Farrington M., Grosmaire L. S., Nonoyama S., Fischer S. H., Hollenbaugh D., Ledbetter J. A., Noelle R. J., Aruffo A., Ochs H. D. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1099–1103. doi: 10.1073/pnas.91.3.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Gordon J. CD23 and B cell activation. Clin Exp Allergy. 1992 Feb;22(2):199–204. doi: 10.1111/j.1365-2222.1992.tb03073.x. [DOI] [PubMed] [Google Scholar]
  8. Jaffe J. S., Eisenstein E., Sneller M. C., Strober W. T-cell abnormalities in common variable immunodeficiency. Pediatr Res. 1993 Jan;33(1 Suppl):S24–S28. doi: 10.1203/00006450-199305001-00128. [DOI] [PubMed] [Google Scholar]
  9. Lane P. Common variable immunodeficiency: does life begin at 40? Clin Exp Immunol. 1994 Feb;95(2):201–203. doi: 10.1111/j.1365-2249.1994.tb06510.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Liu Y. J., Mason D. Y., Johnson G. D., Abbot S., Gregory C. D., Hardie D. L., Gordon J., MacLennan I. C. Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur J Immunol. 1991 Aug;21(8):1905–1910. doi: 10.1002/eji.1830210819. [DOI] [PubMed] [Google Scholar]
  11. Mori S., Kondo N., Motoyoshi F., Kaneko H., Inoue Y., Orii T. Diversity in DNA rearrangements and in RNA expressions of immunoglobulin gene on common variable immunodeficiency. Eur J Immunogenet. 1992 Oct;19(5):273–285. doi: 10.1111/j.1744-313x.1992.tb00070.x. [DOI] [PubMed] [Google Scholar]
  12. Mossalayi M. D., Dalloul A. H., Fourcade C., Arock M., Merle-Beral H., Hofstetter H., Debré P. The role of CD23 on early human hematopoietic precursors. Monogr Allergy. 1991;29:178–185. [PubMed] [Google Scholar]
  13. Pandolfi F., Trentin L., San Martin J. E., Wong J. T., Kurnick J. T., Moscicki R. A. T cell heterogeneity in patients with common variable immunodeficiency as assessed by abnormalities of T cell subpopulations and T cell receptor gene analysis. Clin Exp Immunol. 1992 Aug;89(2):198–203. doi: 10.1111/j.1365-2249.1992.tb06932.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rump J. A., Jahreis A., Schlesier M., Dräger R., Melchers I., Peter H. H. Possible role of IL-2 deficiency for hypogammaglobulinaemia in patients with common variable immunodeficiency. Clin Exp Immunol. 1992 Aug;89(2):204–210. doi: 10.1111/j.1365-2249.1992.tb06933.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Sarfati M., Bron D., Lagneaux L., Fonteyn C., Frost H., Delespesse G. Elevation of IgE-binding factors in serum of patients with B cell-derived chronic lymphocytic leukemia. Blood. 1988 Jan;71(1):94–98. [PubMed] [Google Scholar]
  16. Schena M., Larsson L. G., Gottardi D., Gaidano G., Carlsson M., Nilsson K., Caligaris-Cappio F. Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood. 1992 Jun 1;79(11):2981–2989. [PubMed] [Google Scholar]
  17. Vetrie D., Vorechovský I., Sideras P., Holland J., Davies A., Flinter F., Hammarström L., Kinnon C., Levinsky R., Bobrow M. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases. Nature. 1993 Jan 21;361(6409):226–233. doi: 10.1038/361226a0. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES