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. 1990 Jan;79(1):72–77. doi: 10.1111/j.1365-2249.1990.tb05129.x

Cross-reactive rheumatoid factors in rheumatoid arthritis with extra-articular disease.

M Kinoshita 1, S Aotsuka 1, R Yokohari 1
PMCID: PMC1534729  PMID: 2302836

Abstract

Rheumatoid factors (RF) have been shown to have considerable heterogeneity and bind with IgG as well as with a variety of substances such as nuclear histone, non-histone nuclear protein, nitrophenyl groups or ssDNA. We describe evidence that polyclonal RF cross-reactive with ssDNA (CRRF) are widely distributed in a variety of rheumatic diseases, and that their serum level is significantly higher in rheumatoid arthritis (RA) with extra-articular disease. Although the mechanism of the cross-reactivity is not clear, the presence of CRRF could be a serological feature of a clinical subset of RA. The high prevalence rate of CRRF in RA with extra-articular disease also suggests its pathogenetic role in the extra-articular manifestation of this disease.

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Selected References

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