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. 1990 Jan;79(1):130–134. doi: 10.1111/j.1365-2249.1990.tb05139.x

Reduction of graft-versus-host disease in neonatal F1 hybrid mice.

L DeGiorgi 1, J A Habeshaw 1, S Povey 1, A Matossian-Rogers 1
PMCID: PMC1534730  PMID: 2302831

Abstract

Pre-immunization of BALB/c (H-2d) mothers with C57BL/10 (H-2b) or CBA/H (H-2k) spleen cells partially protected the F1 hybrid offspring of (BALB/c x C57BL/10) or (BALB/c x CBA/H) matings from graft-versus-host-disease (GVHD) induced by neonatal intraperitoneal inoculation with spleen cells of the paternal strain. The effects achieved were manifest as a reduction in mortality. Experiments to establish whether the phenomenon was antibody mediated were performed by passive pre-immunization of BALB/c mothers with alloantisera obtained from BALB/c previously immunized with C57BL/10 spleen cells. Alloantisera produced an equivalent reduction in GVHD mortality. Some of the F1 mice that survived challenge with paternal strain spleen cells were proven to be haemopoietic chimaeras using immunofluorescence with anti-MHC monoclonal antibodies and polymorphism of the enzyme glucose-phosphate-isomerase present in the strains used. The possible mechanisms of protection from GVHD in our mouse model are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adeniyi-Jones S. C., Ozato K. Transfer of antibodies directed to paternal major histocompatibility class I antigens from pregnant mice to the developing fetus. J Immunol. 1987 Mar 1;138(5):1408–1415. [PubMed] [Google Scholar]
  2. BATCHELOR J. R., HOWARD J. G. SYNERGIC AND ANTAGONISTIC EFFECTS OF ISOANTIBODY UPON GRAFT-VERSUS-HOST DISEASE. Transplantation. 1965 Mar;3:161–169. doi: 10.1097/00007890-196503000-00004. [DOI] [PubMed] [Google Scholar]
  3. Bellgrau D., Smilek D., Wilson D. B. Specific systemic graft-versus-host resistance: failure to induce in adult F1 rats tolerized at birth to anti-MHC receptors on parental T cells. Adv Exp Med Biol. 1982;149:563–567. doi: 10.1007/978-1-4684-9066-4_78. [DOI] [PubMed] [Google Scholar]
  4. Berek C. Antibodies specific for different T15 idiotopes induce neonatal suppression of the T15 idiotype. Eur J Immunol. 1983 Sep;13(9):766–772. doi: 10.1002/eji.1830130913. [DOI] [PubMed] [Google Scholar]
  5. Bernabé R. R., Coutinho A., Cazenave P. A., Forni L. Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6416–6420. doi: 10.1073/pnas.78.10.6416. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Butturini A., Gale R. P. T cell depletion in bone marrow transplantation for leukemia: current results and future directions. Bone Marrow Transplant. 1988 May;3(3):185–192. [PubMed] [Google Scholar]
  7. Herzenberg L. A., Herzenberg L. A. Short-term and chronic allotype suppression in mice. Contemp Top Immunobiol. 1974;3:41–75. doi: 10.1007/978-1-4684-3045-5_2. [DOI] [PubMed] [Google Scholar]
  8. Herzenberg L. A., Okumura K., Metzler C. M. Regulation of immunoglobulin and antibody production by allotype suppressor T cells in mice. Transplant Rev. 1975;27:57–83. doi: 10.1111/j.1600-065x.1975.tb00184.x. [DOI] [PubMed] [Google Scholar]
  9. Jerne N. K., Roland J., Cazenave P. A. Recurrent idiotopes and internal images. EMBO J. 1982;1(2):243–247. doi: 10.1002/j.1460-2075.1982.tb01154.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  11. Martinez C., Bernabé R. R., de la Hera A., Pereira P., Cazenave P. A., Coutinho A. Establishment of idiotypic helper T-cell repertoires early in life. Nature. 1985 Oct 24;317(6039):721–723. doi: 10.1038/317721a0. [DOI] [PubMed] [Google Scholar]
  12. Martinez C., Pereira P., Bernabé R., Bandeira A., Larsson E. L., Cazenave P. A., Coutinho A. Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes. Proc Natl Acad Sci U S A. 1984 Jul;81(14):4520–4523. doi: 10.1073/pnas.81.14.4520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SIMONSEN M. The impact on the developing embryo and newborn animal of adult homologous cells. Acta Pathol Microbiol Scand. 1957;40(6):480–500. [PubMed] [Google Scholar]
  14. Sy M. S., Lowy A., HayGlass K., Janeway C. A., Jr, Gurish M., Greene M. I., Benacerraf B. Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors. Proc Natl Acad Sci U S A. 1984 Jun;81(12):3846–3850. doi: 10.1073/pnas.81.12.3846. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Takemori T., Rajewsky K. Mechanism of neonatally induced idiotype suppression and its relevance for the acquisition of self-tolerance. Immunol Rev. 1984 Jun;79:103–117. doi: 10.1111/j.1600-065x.1984.tb00489.x. [DOI] [PubMed] [Google Scholar]
  16. Wikler M., Demeur C., Dewasme G., Urbain J. Immunoregulatory role of maternal idiotypes. Ontogeny of immune networks. J Exp Med. 1980 Oct 1;152(4):1024–1035. doi: 10.1084/jem.152.4.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]

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