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. 1994 May;96(2):335–338. doi: 10.1111/j.1365-2249.1994.tb06563.x

Circulating adhesion molecules in sarcoidosis.

A S Hamblin 1, Z Shakoor 1, P Kapahi 1, D Haskard 1
PMCID: PMC1534875  PMID: 7514516

Abstract

Sarcoidosis is a disease of unknown etiology characterized by non-caseating granulomata together with a number of systemic abnormalities. We have recently shown these include increased expression of the integrins CD11/CD18 on peripheral blood leucocytes. Here we have measured serum levels of the adhesion molecules intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in 23 patients and 14 normal controls using antigen capture sandwich ELISAs. Median circulating E-selectin levels in the patients were nearly three times those of the controls (P < 0.0001, Mann-Whitney U-test), whilst ICAM-1 but not VCAM-1 levels were only slightly elevated. These results show that endothelial cell activation and shedding of E-selectin into the circulation are additional features of the pathology of sarcoidosis.

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Selected References

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