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. 1990 Aug;81(2):244–249. doi: 10.1111/j.1365-2249.1990.tb03325.x

Autoantibodies to mitochondrial and centromere antigens in primary biliary cirrhosis and systemic sclerosis.

N J McHugh 1, I E James 1, K Fairburn 1, P J Maddison 1
PMCID: PMC1535039  PMID: 2117509

Abstract

High levels of IgG antibodies to the multi-enzyme complex bovine pyruvate dehydrogenase (PDHC) were detected by a sensitive ELISA in all patients with histologically proven primary biliary cirrhosis (PBC), in a minority of patients with systemic sclerosis without overt PBC or with chronic liver diseases of another cause and in no rheumatoid arthritis or normal controls. Most (15/21) but not all of these positive patients recognized a 70-kD (E2) component of PDHC on immunoblotting. Additional recognition of a centromere-associated 140-kD polypeptide was associated with the presence of scleroderma-like features (Raynaud's phenomenon and sclerodactyly) in PBC, further emphasizing the serological and clinical overlap between these two conditions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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