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. 1994 Mar;95(3):525–529. doi: 10.1111/j.1365-2249.1994.tb07030.x

Induction of autoimmune disease by graft-versus-host reaction across MHC class II difference: modification of the lesions in IL-6 transgenic mice

T Kimura, K Suzuki, S Inada, A Hayashi, H Saito, T Miyai, Y Ohsugi, Y Matsuzaki, N Tanaka, T Osuga, M Fujiwara
PMCID: PMC1535069  PMID: 8137550

Abstract

We examined the effect of IL-6 on the development of autoimmune diseases (primary biliary cirrhosis, Sjögren's syndrome) employing murine graft-versus-host reaction (GVHR) model with MHC class II disparity. For this purpose, we used IL-6 transgenic (B6.6) mice in which a high level of IL-6 was detected. C57B1/6 (B6) spleen T cells were injected into B6.6 mated with B6.C-H-2bm12 (bm12) mutant mice ((bm12×B6.6)F1) and GVHR with MHC class II disparity was induced. The transgenic hybrid mice with GVHR showed a larger spleen index and contained a higher serum level of IL-6 than those without GVHR. Autoimmune-like lesions in transgenic recipients became weakened compared with those in non-transgenic (bm12×B6)F1 recipients. In contrast, levels of antimitochondrial antibodies in (bm12×B6.6)F1 GVHR group were significantly higher than that of (bm12×B6)F1 GVHR group. These results indicate that IL-6 excessively produced in vivo might regulate the progression of autoimmune diseases.

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Selected References

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