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. 1990 Nov;82(2):221–226. doi: 10.1111/j.1365-2249.1990.tb05430.x

Interferon-gamma potentiates antibody affinity in mice with a genetically controlled defect in affinity maturation.

G P Holland 1, N Holland 1, M W Steward 1
PMCID: PMC1535105  PMID: 2122931

Abstract

Interferon-gamma (IFN-gamma), the tetrapeptide tuftsin and the synthetic nonapeptide from interleukin-1 beta (IL-1 beta) (amino acids 163-171) have previously been shown to act on macrophages and/or T cells and to enhance antibody titres to T cell-dependent antigens. The ability of these immunomodulatory agents to potentiate antibody affinity in addition to antibody titre has been studied in a line of mice that fail to demonstrate normal maturation of antibody affinity (low N/M mice). The results presented here confirm that each of the agents potentiate antibody levels following simultaneous injection with a T cell-dependent antigen but demonstrate that only IFN-gamma is able to enhance antibody affinity in these mice. The observation that IFN-gamma can enhance both antibody affinity and antibody levels suggests that it could be an important adjuvant for vaccine use.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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