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. 1990 Nov;82(2):350–354. doi: 10.1111/j.1365-2249.1990.tb05451.x

Anomalous expression of HLA class II molecules on keratinocytes and fibroblasts in hypertrophic scars consequent to thermal injury.

C Castagnoli 1, M Stella 1, G Magliacani 1, S T Alasia 1, P Richiardi 1
PMCID: PMC1535117  PMID: 1700745

Abstract

Immunoperoxidase staining of skin sections obtained from 11 hypertrophic scars, six normotrophic scars and three samples of normal skin were performed using anti-HLA monoclonal antibodies (HLA-DR, -DQ, class I), anti-interleukin-2 receptor (IL-2R) and anti-CD1. Sections from all hypertrophic scars showed an anomalous expression of HLA-DR molecules on keratinocytes and fibroblasts. Moreover hypertrophic scars were characterized by dense infiltrates of IL-2R-positive cells and by the presence of abundant Langerhans (CD1+) cells in the epidermis and dermis. These results support the hypothesis that immunologic mechanisms play an important role in hypertrophic scarring and point to an involvement of cell-mediated immune phenomena.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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